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Biomedical subjects

G Dobrescu

Publications and source records attributed to G Dobrescu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Histochemical and histoenzymic researches in coronary sudden death.

Using Lie's technique in order to evidence the fuchsinophilia of the early ischaemic zones and Falck-Hillarp's technique to appreciate the disappearance of the myocardial adrenergic network, the authors followed up the concordance between the precocity of the ischaemia and the frequency of the acidophilia. Studying 54 cases of coronary sudden death by using 100-300 slides in each case, the fuchsinophilic zones were evidenced in 46 per cent of the cases, aspects indicating the morphologic substrate of the sudden death with ectopic ventricular electrical activity centres. The results of fluorescence Falck-Hillarps's technique are the same as those obtained by light microscopy, which is to be preferred in routine practice. Farber-Louvière's microscopic histoenzymic method for succinate-dehydrogenase presents multiple advantages, so that it is preferable to Kollin-Neoral's macroscopic reaction.

Catecholamines↗
PubMedDate not supplied

[Metabolic and cardiovascular changes in experimental diabetes, stress and orchiectomy].

When Aloran (Al) was administered to normal or orchiectomized animals, the adult ones proved to be more sensitive, most normal animals (77.7%) developing a DAla and the remainder (22.3%) a DAlc, while of the orchiectomized animals 66.6 developed a DAlc and 33.4% presented a decreased glucose tolerance. 33.4% of the young normal developed a DAla and 66.7% a DAlc, while of the young orchiectomized ones 33.4% presented a DAlc and 66.7% a STG. No matter of age, orchiectomy induced an increased resistance to the various action of Al. Glycemia and lipid fractions, especially LT and TG were significantly elevated in the normal animals with DAla and in the young orchiectomized animals with DAlc. Insulinemia was elevated in most young animals, except for the orchiectomized ones with DAlc, in which it decreased. Serum cholesterol was the most markedly elevated in the adult animals belonging to the group ACTH + D2 + Al, form DAlc. Histopathologically, in this last group degenerative lesions and microcalcifications in aorta and interstitial infiltrate and homogenization of myocardial fibres in the myocardium were found.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Differentiated thyroid cancer].

In the interval 1979-1988, out of 1070 operated goiters 77 malignant thyroid tumors were recorded, 60 of them being differentiated: papillary--32 (53.4%), vesicular--12 (20%), mixed forms--16 (26.7%). The differentiated thyroid carcinomas had peculiar clinical biological and prognostic features and were framed: stage I--60%, stage II--23.4% and state III-IV--16.6%. Only 15 cases presented lymph node metastases. In 16 cases the thyroid tumor was associated with another thyropathy: Hashimoto's thyroiditis--5 cases, Basedow's disease--1 case. The surgical intervention was performed in two times: first total lobectomy or total lobo-isthmectomy [correction of lobioistectomy] with contralateral subtotal exeresis, then total thyroidectomy. It is insisted upon a careful surveillance of postoperative evolution (clinical, biological, scintigraphy) in order to detect the recurrence and apply a proper treatment.

Adult↗
PubMedDate not supplied

[The effects of vitamin D2 on the lipid profile and on the platelet and cardiovascular activities in castrated or testosterone-treated male rats].

The changes in serum and hepatic lipid fractions (LT, Col, TG, beta-LP), aggregability indices (IAg), platelet adhesiveness (IA), atherogenicity (Ia) and microscopic aspect of aorta and myocardium in three groups of animals injected with vitamin D2: normal, orchiectomized and treated with testosterone, were followed up. In the normal animals the injection of vitamin D2 induced the increase of all lipid fractions, of IA, IAg, Ia and histologically microcalcifications at the coronaries level were present; in the orchiectomized animals the biochemical changes were less marked and histologically thickenings of aortic and coronary endothelium with areas of intestinal sclerosis in the myocardium were found. In the animals with hyperandrogenism, the administration of vitamin D2 induced the decrease of TG and increase of IAg and IA; histologically, aspects similar to those noticed after the administration of testosterone alone were present. It is concluded that hypervitaminosis D induces a marked increase of serum lipid fractions in the normal animals, while the histological examination revealed more marked changes in conditions of sexual function cessation.

Animals↗
PubMedDate not supplied

[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. I. The effect of the pharmaceutical product Boicil tablets on fertilization and implantation in rats and mice].

The teratogen action of Boicil tablets was studied in two animal species, rats and mice, the prefertilization and implantation stages being the main interest. Three generations of animals were followed up. The active powder suspended in distilled water (0.1 ml/10 g for mice and 1 ml/100 g for rats) was administered per os in a single dose, prepared on spot and in two doses, 2 mg/kg body weight and 20 mg kg body weight, respectively. The administered doses were equivalent to the daily maximum therapeutic dose prescribed in humans (110 mg active principle). The first gestational day was determined differently in the two species. For estimating the effect on prefertilization, Boicil tablets was administered for 5 days before making and for its effects on the number of implantations during the first 3 gestational days. The two parameters under investigation were within normal limits and all newborn animals followed up for three generations did not present pathological microscopic and gross alterations or somatic malformations. It was concluded that Boicil tablets is not teratogenic.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Further comment on the importance of microscopy in clinical microbiology. The argument for the diagnosis of the skin manifestations of histoplasmosis and coccidioidomycosis].

This paper presents two interesting cases: a patient with cutaneous coccidioidomycosis, the first case in Romania, and a female patient with latent histoplasmosis with cutaneous manifestations, periodically reactivated during her pregnancies. The etiological diagnosis problems of these affections in relation with the degrees of competence of the clinical laboratories is discussed. The role of direct microscopic examination in the early and more rapid diagnosis of deep mycoses is underlined.

Adult↗
PubMedDate not supplied

[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. II. The effect of the pharmaceutical product Boicil tablets on early embryogenesis, organogenesis and the fetus in 3 successive generations of rats and mice].

The effect of Boicil tablets on early embryogenesis (the first 3 gestational days), organogenesis (the 10th, 11th and 12th gestational days) and fetus (the 18th and 19th gestational days) by its intraamniotic administration was followed up in three successive generations of mice and rats. Two doses were used (2 mg/kg body weight and 20 mg/kg body weight), estimated in relation with the maximum therapeutic daily dose in man, being administered in a single dose, per os. No inborn malformations or somatic abnormalities were recorded both in mothers and in their descendents for three successive generations. It is concluded that Boicil tablets is not teratogenic.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Microcirculation study by video-monitored intravital microscopy].

As a result of a interdisciplinary team's work, the in vivo study of microcirculation by video monitoring systems, adapted to the optic microscopy, opens new perspectives for the fundamental as such for the clinical and pharmacological research. The multiple possibilities of image acquisition on video tapes, as well as on colour films, offers a variety of post processing of the images through dedicated computer based programs, in order to obtain a precise measurement of the changes occurring in the living tissues. Furthermore, this technical devices along with a proper directed health program, may be used as a modern diagnostic tool in populational screening.

Animals↗