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G Dimitrov

Publications and source records attributed to G Dimitrov.

79 records · Page 5Linked to original sources
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[Effect of prolonged hyperoxia on rabbit lung lipids and their fatty acid content (author's transl)].

The effect of a 36-hour hyperoxia (60 % oxygen) on rabbit lung lipids has been investigated. It has been established that hyperoxia leads to the increase of all lipid fractions in lung tissue and alveolar surfactant, phospholipid and cholesterol being most significantly affected. It has also been found that hyperoxia leads to the decrease of palmitic acid and to the increase of linoleic and arachidonic acids almost in all lipid fractions. Marked changes in the positional distribution of fatty acids in alveolar surfactant phosphatidylcholine have also been observed. The possible mechanisms of the effect of oxygen on lung lipid metabolism have been discussed, and the consequences ensuing from it which could affect the structural organization of membranes have been evaluated.

Animals↗
PubMedDate not supplied

Insulin effect on lung subcellular fraction phospholipids and cholesterol.

Lung subcellular fraction (microsomes, mitochondria, 105 000 X g supernatant and plasma membranes) were isolated from normal and insulin treated rats. Phospholipid and cholesterol contents were determined, phosphatidylcholines and phosphatidyl-ethanolamines separated and their fatty acid profiles assayed. Teh investigations carried out indicated that insulin influenced the phospholipid content of all fractions. Cholesterol levels in the 105 000 X g supernatant and especially in the plasma membrane fraction were raised significantly. Insulin administration increased the contribution of the unsaturated long chain fatty acids in both phospholipids studied. The results are discussed in relation to stimulated lipid biosynthesis and to lipid fluidity, of which fatty acyl unsaturation and cholesterol level are main parameters.

Animals↗