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Biomedical subjects

G Dickstein

Publications and source records attributed to G Dickstein.

41 records · Page 3Linked to original sources
PubMed1979

Bromocriptine and endocrine disorders.

Bromocriptine, a dopaminergic agonist, has been used to treat many endocrine disorders. In hyperprolactinemia associated with galactorrhea, amenorrhea, oligospermia, and impotence, bromocriptine reduces prolactin levels to normal and allows for satisfactory return of sexual and reproductive function in 90% of patients. In acromegaly, bromocriptine brings about subjective improvement in 75% of patients with reduction in growth-hormone levels to normal in 22% of patients. Bromocriptine has been used in premenstrual tension, functional infertility, Nelson's syndrome, and Cushing's disease with variable benefit. In low doses, side-effects are minimal. In higher doses, digital vasospasm and gastrointestinal bleeding have occurred. Although bromocriptine has been used in a wide variety of endocrine disorders, it appears to be most useful in treatment of male and female infertility associated with hyperprolactinemia.

Acromegaly↗
PubMed1978

Cholestatic jaundice caused by D-penicillamine.

D-penicillamine is not generally considered to cause hepatic damage. Cholestatic jaundice developed in a patient with rheumatoid arthritis 4 weeks after penicillamine was added to his regimen, and he died in acute renal failure. The probability that penicillamine caused the cholestasis is discussed.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Induction of spermatogenesis in isolated hypogonadotropic hypogonadism with exogenous human chorionic gonadotropin.

A 21-year old male patient with isolated hypogonadotropic hypogonadism (IGD) is described. Basal serum levels of testosterone (0.5 ng/ml), FSH (2.1 mIU/ml) and LH (2.3 mIU/ml) were low and did not respond to administration of clomiphene citrate. The FSH and LH responses to LHRH were normal. Pituitary-thyroid and pituitary-adrenal function as well as GH reserve were also normal. However, prolactin (PRL) response to both TRH and metoclopramide were blunted compared with normal male subjects. The patient was treated with human chorionic gonadotropin (HCG). Within 20 months he developed full testicular maturation with spermatogenesis and full androgenization. Serum testosterone levels rose to 6.5-13.5 ng/ml. Both basal serum PRL levels and the response to TRH and metoclopramide became normal. Spermatogenesis and androgenization proceeded in the absence of FSH. These results suggest further trials of treatment with HCG alone in patients with IGD are warranted.

Adult↗
PubMedDate not supplied

Thyrotoxicosis induced by amiodarone, a new efficient antiarrhythmic drug with high iodine content.

Amiodarone is an antiarrhythmic agent with high iodine content. Ten patients treated with amiodarone developed thyrotoxicosis. I131 uptakes were negligible, and TT3 levels low in relation to TT4 levels, and sometimes even normal. Cessation of amiodarone caused thyroid functions to return to normal in one to five months, unrelated to propylthiouracil treatment. Eight of the patients had normal thyroid glands on radioscan or palpation. All patients tested had normal TRH tests. Thyrotoxicosis is a relatively common complication of amiodarone treatment, probably caused by its high iodine content. It is possible in apparently normal thyroid glands, suggesting failure of the homeostatic mechanisms controlling thyroid synthesis and release in these patients. Amiodarone is very efficient in controlling tachyarrhythmias and angina pectoris, situations in which thyrotoxicosis is dangerous. Thyroid function tests should therefore be drawn periodically, and the complication considered whenever tachyarrhythmias worsen on treatment with amiodarone.

Aged↗