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Biomedical subjects

G Destro

Publications and source records attributed to G Destro.

23 records · Page 2Linked to original sources
PubMed1990

[Evaluation of complications during laser angioplasty with a hot tip system in the treatment of peripheral arteriopathy].

"Hot tip" laser angioplasty has been used in the treatment of peripheral artery disease. The purpose of our study (the largest in Italy) is to evaluate the complications during the recanalization of stenotic and occluded iliac and femoro-popliteal arteries, using a hot tip laser system coupled to an Argon or Nd Yag laser. One hundred twenty-three patients have been treated. The complications were: arterial spasm in 2 patients; distal embolizations in 6 patients; arterial dissections in 35 patients; vessel wall perforations in 20 patients. Vessel wall perforation is the more severe complication and did never allow to complete the procedure. The presence of intravascular calcified deposits increases the risk of perforation, due to the loss of the coaxial position of the probe. Only the development of a guided laser system could allow a safer delivery of laser radiation, reducing the risk of arterial wall perforation.

Adult↗
PubMed1990

[Effects of magnesium pidolate on cardiovascular hemodynamics].

Aim of this study is to define the hemodynamic effects of magnesium (Mg) in patients with ischemic heart disease. Thus, the effects of 1 g of Mg pidolate injected over 3 min iv were evaluated in 10 patients by analysis of pressure data from a micromanometer catheter in the left ventricle and of volume data derived from Doppler and 2-dimensional echocardiography. Recordings were made before and immediately after the injection, at 3, 5, and 8 min. At 5 min, Mg induced a significant reduction in left ventricular peak systolic pressure (from 132.4 +/- 19.4 to 122.7 +/- 17.5 mmHg, p = 0.015, with early filling notably augmented (E wave of Doppler curve; from 39.4 +/- 8.5 to 43.9 +/- 9.7 cm/s, p = 0.013) and a slight increase in cardiac output (from 6.23 +/- 1.4 to 6.9 +/- 1.7 l/min, p = 0.092). Heart rate increased (from 75.9 +/- 9.6 to 78.13 +/- 8.4 b/min, p = 0.062) and the constant of isovolumetric pressure decay decreased (from 48.9 +/- 13.2 to 45.7 +/- 14.9 ms, p = 0.065), probably as a final effect of aortic pressure reduction. The diastolic pressure-volume relationship was insignificantly displaced downward (p = 0.11) and to the right (p = 0.62). In conclusion, Mg unloads the ischemic left ventricle through a reduction of systemic aortic pressure, with a secondary increase in early filling; this increase may derive from a rise in the atrioventricular diastolic gradient, subsequent to an improvement in ventricular emptying. Active relaxation is improved, and passive diastolic properties are not affected, in spite of the reported calcium-antagonist action of the drug.

Adult↗
PubMed1989

[Doppler-hemodynamic evaluation of variations in left ventricular filling due to reduction of external mechanical compression].

It has been recently shown that preload reduction affects the pattern of left ventricular (LV) filling in a way that mimics those Doppler changes that have been associated with impaired LV diastolic function. In order to better relate changes of mitral flow velocity profile to changes of the diastolic properties of the ventricle, in 11 ischemic patients diastolic pressure-volume relations from micromanometer LV pressure and LV volume derived from Doppler and 2D-echocardiography were constructed before and after TNT (0.2 mg iv). TNT induced a significant reduction in LV peak pressure (% change: -13 +/- 7%, p: 0.0003), end-diastolic pressure (EDP) (-62 +/- 45%, p: 0.0006), and constant of isovolumic pressure decay (T) (-8.4 +/- 6.6%, p: 0.012). The left atrial pressure at the time of mitral valve opening (PCO: defined as the pressure at the time of initial transvalvular flow assessed by Doppler) decreased 5.3 +/- 9.6 mmHg (p: 0.11). The early filling E wave of the Doppler velocity profile was significantly reduced by TNT (-20.1 +/- 12.7%, p: 0.0003), while the atrial contribution to total filling increased by 21.3 +/- 29.7% (p: 0.03). The E/A ratio decreased from 0.87 +/- 0.31 to 0.66 +/- 0.22 (p: 0.016), and the change correlated with changes in EDP (p less than 0.05) and PCO (p less than 0.01). The diastolic pressure-volume relationship was displaced downward (p: 0.0007) and minimally leftward (p: 0.45), suggesting relief of external constraint.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Disease↗
PubMedDate not supplied

Senile diabetes and bone mineral density.

Bone mineral density was determined in a series of 67 elderly diabetics (38 males and 29 females) and 40 non-diabetic elderly subjects (20 males and 20 females) at the third medial and tenth ultradistal of the non-dominating radius using an X-ray densitometer (DEXA). Bone metabolism markers (Ct, PTH, HOP, UCA, AP, Vit-25-OH-D, BGP) were also measured. Our results indicate that there is no significant difference in values of BMD and the bone metabolism markers studied between diabetic and non-diabetic elderly subjects. We believe that senile diabetes is not a risk factor of onset and maintenance of senile osteoporosis.

Journal Article↗