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Biomedical subjects

G Desmet

Publications and source records attributed to G Desmet.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Radioecology: trends and future in the light of societal changes.

Radioecology is an unusual scientific discipline, in that there do not exist radioecologists, but that there exists a research domain with well-defined objectives! The science of Radioecology is per definition "multidisciplinary". The science of radioecology has a number of important objectives relevant to the radioactive contamination of the environment. A prime objective of radioecology is to understand how the interaction between radionuclides and the environment affects radiation dose. Such an understanding then permits a second major objective of radioecology, which is to provide suitable rehabilitation methodology to reduce radiation dose so that it is possible to restore the ecological and economic value of contaminated land.

Ecology↗
PubMedDate not supplied

[Comparison of the fluoride bioavailability from two oral preparations of monofluorophosphate disodium in combination with various calcium salts].

We studied, in twelve healthy volunteers, the pharmacokinetics of inorganic fluoride and calcium variations in serum and urine, parathormone variations in serum after administration of two oral preparations containing 100 mg of disodium monofluorophosphate (13.2 mg F as element) with different calcium salts (500 mg Ca as element). Fluoride was estimated in serum and urine with an ion specific electrode. The fluoride bioavailability from two preparations is identical with an areas under the curve corresponding to 61.05 and 62.53 mumols.l-1 h (after deduction of physiological fluoride concentrations) and urinary fluoride excretion after 72 hours corresponding to 266.6 and 246.1 mumols. The plasma peak appearance is rapid (one hour) and similar. The significant increase of urinary Ca-Creat ratio (70 to 100%) is identical four hours after drug administration. In the same way, a significant and early decrease of intact PTH in serum, measured with chemiluminometric method, was observed from two drugs. From these observations we may conclude that the two preparations are biologically equivalent.

Administration, Oral↗
PubMedDate not supplied

Effects of arginine butyrate and tributyrylxylitol on cultured human sarcoma cells.

The effects of arginine butyrate and tributyrylxylitol were studied comparatively in a human sarcoma cell line. Both induced important structural and functional modifications suggestive of cell differentiation, as shown by the dose-dependent increase of alkaline phosphatase activity and total protein content, at concentrations ranging from 1mM to 5 mM expressed in butyrate equivalents. hCG beta-subunit present in the culture medium increased with differentiation. Our results show that most of the differentiation changes previously reported for sodium butyrate in cancer cell lines are also produced by both drugs. Tributyrylxylitol appears to be the more potent and effective inducer of differentiation but its use is limited << in vitro >> on account of its relative toxicity at concentrations above 3 mM butyrate equivalents.

Alkaline Phosphatase↗