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Biomedical subjects

G Delvecchio

Publications and source records attributed to G Delvecchio.

5 recordsLinked to original sources

[Pneumothorax in AIDS].

A total of 237 patients with AIDS have been observed in the infectious Disease Division of the United Hospitals of Bergamo during the past six years. Five patients (4.21%), suffering from TB and PCP, revealed PNX which was characterised by being bilateral and recurrent; it was a concomitant cause of death in 2 patients. The complications which occurred included acute pulmonary heart, pulmonary edema due to reexpansion and irreversible shock.

Acquired Immunodeficiency Syndrome

Brucella endocarditis.

Between 1987 and 1990, three patients with abscesses produced by Brucella endocarditis were admitted to the Department of Infectious Diseases, "Ospedali Riuniti", Bergamo, Italy. In each case, the diagnosis was based on a history of ingestion of milk products, positive Wright serology, positive blood and valvar culture, and echocardiography. Medical therapy alone was not found to be effective in treatment, all patients requiring surgical intervention. One case required urgent surgical treatment and underwent three further operations up to the final implantation of a valved tube. According to our experience, Brucella endocarditis is a rare but serious disease which requires a combination of medical and surgical therapy.

Abscess

[Mortality and HIV infection in a group of intravenous heroin addicts from 1985 to 1989].

One hundred and eighty-seven heroin addicts resident in Valle Seriana Superiore were monitored from July 1985 to July 1989. This sample was representative of a total population of drug addicts estimated at some 350 subjects, 90 of whom (48.1%) were HIV-positive in Elisa assays and Western blot control tests. Six patients (3.2%) died; 3 of whom (3%) were HIV-positive and 3 (3.3%) were HIVab-negative. The most frequent cause of death (59%) was heroin overdose, which occurred in both HIV-positive and negative subjects, showing that the fear of contracting the disease or its possible evolution is not a deterrent in modifying risk behaviour. During the four years of the study, 5 (5.5%) of the HIV-positive patients developed confirmed AIDS. Only one patient died from AIDS, thus confirming the current risk of death as being 1.1% in seropositive patients. An increase in mortality due to AIDS is expected in the future, in line with the current prevalent mortality rate due to heroin overdose.

Acquired Immunodeficiency Syndrome

[HIV infection in the population of the upper Seriana Valley USSL 25].

The drug addiction unit of USSL 25 in the Upper Seriana Valley, Clusone (BG), have dealt with HIV infection since 1985. Over the past four years 357 subjects, 90 (48.1%) of whom proved to be HIV-positive using ELISA methods and Western control blotting. Five drug addicts included in the study underwent seroconversion. Clinical symptoms evolved in thirteen-drug addicts and five were diagnosed with AIDS. Two children of seropositive mothers were found to be HIV-positive and therefore form part of the high-risk non-drug-addict population. All subjects who were not at risk were found to be seronegative. The ned for primary preventive therapy is underlined.

Acquired Immunodeficiency Syndrome

Bilateral pigmented retinopathy following measles: long-term follow-up and possible association with keratoconus.

A case of pigmentary retinopathy following measles is presented with follow-up of 24 years. A 29-year-old man complained of almost complete blindness during measles infection at the age of 5 (1966). Ophthalmoscopy revealed retinal edema with pallor of the optic disc and in a few months pigment alterations gave the fundus a salt-and-pepper appearance. In 1974 and 1985 a pigmentary retinopathy was present with optic atrophy and typical bone corpuscle deposits, and marked impairment of visual function. In 1990 (i.e. 24 years after the onset of symptoms) the fundus shows pigmentary degeneration with optic atrophy and narrowed vessels, ERG is extinguished and visual fields and dark adaptation cannot be recorded owing to amaurosis. The patient also present bilateral keratoconus. The possible association between these two entities, which to our knowledge has not been previously reported, is discussed.

Adult