Search PubMed⌕ Search

Biomedical subjects

G Delvaux

Publications and source records attributed to G Delvaux.

27 records · Page 2Linked to original sources
PubMed1986

Postprandial stimulation of epithelial cell proliferation in defunctioned colon of rats is not caused by gastrin.

Rats were submitted, at random, to either a diverting colostomy alone or to antrectomy with a colostomy. After a 48-h fasting period, animals from each group were refed, whereas control animals were kept fasting. Animals were killed at 0, 6, 12, 18, and 24 h after the time of refeeding. In vitro labeling of colon mucosa with [3H]thymidine and autoradiography were performed to determine the proliferative parameters in the colonic crypts, and scintillation counts on mucosal scrapings were used for the estimation of mucosal deoxyribonucleic acid synthetic activity. Refeeding increased the labeling index (p less than 0.01), mitotic index (p less than 0.01), and mucosal deoxyribonucleic acid synthesis activity (p less than 0.01) in the proximal colon as well as in the defunctioned distal segment. Despite suppression of the postprandial rise in serum gastrin (p less than 0.01), antrectomy did not abolish the proliferative reaction in any colonic segment. These data confirm the existence of a potent stimulant of colonic cell proliferation that is released systematically after feeding. They indicate that gastrin is not the responsible stimulant and that another, yet unknown, physiological factor is involved.

Animals↗
PubMed1984

Refeeding of fasting rats stimulates epithelial cell proliferation in the excluded colon.

The major postprandial factors known to influence epithelial cell proliferation in the colon are intraluminal factors. In this study, a transverse colostomy was created in rats in order to avoid the intraluminal stimulation of the distal colon after feeding. After a 48-h fasting period, the animals were refed whereas controls were kept fasted. Refed animals with their controls were killed at respectively 0, 8, 12, 18, and 24 h after the time of refeeding. Autoradiography of in vitro labeled mucosal samples was used for determining the proliferative parameters in the colonic crypts. The uptake of [3H]thymidine in mucosal scrapings was measured for estimating DNA synthetic activity. Refeeding increased the labeling index of the crypts (p less than 0.01) and the mucosal DNA synthesis (p less than 0.01) not only in the proximal colon but also in the excluded distal colon. The increase in labeling index was followed by a significant mitotic peak in both segments. These data indicate that direct intraluminal stimulation is not the only mechanism involved after feeding. There are other potent physiological stimulants of epithelial cell proliferation in the colon which are released postprandially.

Animals↗
PubMed1983

Influence of a diverting colostomy on epithelial cell proliferation in the colon of rats.

The effect of a transverse colostomy was compared to a sham operation and to transsection of the colon with reanastomosis in rats. The autoradiographic study after labeling with tritiated thymidine showed a significant decrease in proliferative activity at 5 days and at 3 weeks in the colonic segment distal to the colostomy. This observation was confirmed by the occurrence of mucosal atrophy and by a significant decrease in the mucosal DNA synthesis activity. It was concluded that the intraluminal presence of fecal bulk is an important factor in the maintenance of cell renewal in the colon of rats. Other factors seem, however, to be involved since a delayed but significant decrease in proliferative parameters was also observed proximal to the colostomy; no mucosal atrophy occurred in the latter segment.

Animals↗
PubMedDate not supplied

Thoracic epidural bupivacaine-fentanyl anesthesia for percutaneous cholecystolithotomy in high-risk patients.

BACKGROUND AND OBJECTIVES: The efficacy of a thoracic epidural block was assessed in 12 high-risk patients scheduled for elective percutaneous cholecystolithotomy. METHODS: A thoracic epidural catheter was inserted at level T8-9. The amount of 0.5% bupivacaine to block two thoracic epidural segments was calculated, adapted to age, height, and epidural level, and administered with 50 micrograms fentanyl. Hemodynamic and respiratory variables and patients' pain and movement were assessed throughout the procedure. RESULTS: Anesthesia was obtained with a minimal dose of local anesthetic. All patients were satisfied with this method. Neither hemodynamic nor respiratory impairment were observed after epidural injection. However, vagal reactions reported in other studies occurred in two patients upon puncture of the gallbladder. CONCLUSIONS: This minimally invasive anesthetic technique seems to be a good alternative for high-risk patients. However, careful monitoring of heart rate and blood pressure remains mandatory throughout the procedure.

Adult↗
PubMedDate not supplied

Solitary exulceratio simplex (ulcer of Dieulafoy).

Solitary exulceratio simplex (ulcer of Dieulafoy--Dieulafoy vascular malformation) is a rare and frequently overlooked cause of massive gastric hemorrhage. The source of the bleeding, a large, submucosal artery penetrating the centre of a small mucosal defect, is usually located in the upper portion of the stomach. The pathogenesis of this entity is not known. We report on two patients who were successfully treated by surgery. Clinical, morphological and pathogenetic aspects are discussed.

Adult↗
PubMedDate not supplied

Retroperitoneal leiomyosarcoma.

The clinical history, radiological investigations, pathologic findings and treatment of four patients affected by retroperitoneal leiomyosarcoma were compared with data of the literature. These tumors have a great tendency to develop local recurrences after excision, but metastases to lymph nodes and distant organs usually occur lately. CT examination of the retroperitoneal space is a sensitive tool in the diagnosis and follow-up. Complete excision of the tumor followed by radiotherapy improves significantly the prognosis. Chemotherapy is advisable only when disseminated metastases appear. No correlation was found between the histologic appearance and the clinical behaviour.

Adult↗
PubMedDate not supplied

[Whole bowel irrigation as preparation for colorectal surgery].

One hundred consecutive patients underwent a whole gut irrigation as preoperative care for surgery of the large intestine. The solution used was balanced for isotonicity with mineral salts and polyethylene glycol. The procedure was quite well tolerated by the patients, also by the elderly. Only slight changes in body weight or in serum ionic concentrations were noted. In 88% of the patients the preparation was considered to be good or excellent by the operating surgeon. There was a tendency for low rate postoperative infections.

Adult↗
PubMedDate not supplied

Is laparoscopic splenectomy a justified approach in hematologic disorders? Preliminary results of a prospective multicenter study. Belgian Group for Endoscopic Surgery.

The feasibility and safety of laparoscopic splenectomy were evaluated in a prospective multicenter study of 50 patients operated on for idiopathic thrombocytopenic purpura (ITP) (n = 31), hereditary spherocytosis (n = 6), hemolytic anemia (n = 4), Hodgkin's disease or lymphoma staging (n = 5), benign splenic tumors (n = 3), and wandering spleen (n = 1). Conversion to laparotomy was required in 10%. An accessory spleen was routinely searched for, although the lesser sac was opened during surgery in only 10%; the overall incidence was 14%. Hospital mortality was 2% and postoperative morbidity 22%. Postoperative hospital stay and home rehabilitation were improved when exclusively laparoscopic splenectomy was performed. In ITP patients, at a mean follow-up of 8.2 months, 8 patients (27%) had recurrence of thrombocytopenia, which was transient in 7% and permanent in 20%. Laparoscopic splenectomy is feasible and safe when performed in selected patients by expert laparoscopic surgeons. Adequate selection of patients and routine, careful search for accessory spleen are critical. The recurrence rate (20%) for ITP was high at 8.2 months, and this factor is the major limitation of laparoscopic splenectomy at present.

Adolescent↗