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Biomedical subjects

G De Santis

Publications and source records attributed to G De Santis.

At least 37 records · Page 2Linked to original sources
PubMed1990

Effect of postoperative radiation on the incorporation of tibial bone grafts in the rabbit.

A dose of 48 Gy of X-irradiation given over two to five weeks after grafting caused no significant delay in the rate of healing and only a small and statistically non-significant decrease in the torsional strength of the graft-bone junction of either vascularised or non-vascularised bone grafts of the tibiae of rabbits. Healing was faster and the union between the graft and adjacent bone developed torsional strength significantly more rapidly with vascularised than with non-vascularised grafts. These findings suggest that postoperative radiotherapy is unlikely to have a significantly deleterious effect on the healing of bone grafts used to repair defects produced by excision of malignant bone tumours.

Animals↗
PubMed1989

CT in established Volkmann's contracture in forearm muscles.

Differential diagnosis between true and pseudo-Volkmann's contracture should not be based on clinical grounds alone, because clinical data are often insufficient in determining the severity and the extent of muscle damage. CT has been utilised in 11 cases where a flexion contracture of the forearm muscles was present and corresponded closely with the surgical findings. True and pseudo-Volkmann's contracture can thus be distinguished and the severity and extent of the muscle damage determined.

Adolescent↗
PubMed1989

The deleterious effect of arteriovenous flow reversal during experimental free muscle transfer.

Arteriovenous flow reversal (AVR) has been used experimentally to salvage ischemic limbs and to create novel skin flaps with some success. The clinical applicability of AVR in muscle by way of two arteriovenous anastomoses in the rabbit was investigated. Twenty-four rabbits were divided into two groups. In Group 1 (control), the rectus femoris muscle was harvested and transplanted in the opposite thigh, anastomosing the donor femoral artery to the recipient femoral artery, and the donor rectus femoris vein to the recipient femoral vein. In Group 2 (flow reversal), the same procedure was done except the donor artery was anastomosed to the recipient vein and vice versa. Six and 24 hr postoperatively, specimens were compared macroscopically and by weight and histology. Reversed flow muscles were significantly heavier than control muscles at 6 hr and at 24 hr. Histologically, 6 hr of AVR caused edema, intramuscular hemorrhage, neutrophil infiltration, and thrombosis of most vessels. By 24 hr muscle cell degeneration was well advanced. All control muscles were viable, with only mild edema and slight peripheral necrosis. Possible reasons for the failure of AVR in muscle are discussed. On the basis of these results, AVR in free muscle transfer is not advocated.

Animals↗
PubMed1989

The use of CT scan in evaluating Volkmann's syndrome in the limbs.

Between January 1980 and October 1986 26 cases of Volkmann's syndrome were submitted to preoperative CT scan. Thirteen were localised in the upper limb, 11 in the lower limb, and 2 were cases of pseudo-Volkmann's disease. CT scan allowed us to confirm the densitometric features and distribution of muscle infarction in the various muscle planes. Thus, two groups were distinguished, each with different densitometric features: a first group with diffuse hypodensity of the muscular sheaths with unclear borders, and a coefficient of attenuation at approximately 30-40 H.U., which at operation corresponded to diffuse fibrosis; a second group with defined hypodensity of the various muscle groups equal to 10-20 H.U., which at operation gave a macroscopic picture of infarction. CT scan provides a detailed preoperative topographical and morphological evaluation of the infarction area, and therefore a treatment plan based on a more accurate knowledge of the anatomical and pathological lesions.

Adolescent↗
PubMed1986

Human eosinophils and parasitic diseases--III. Beta-interferon increases eosinophil IgG-Fc receptor expression and capacity.

Eosinophilic granulocytes from the blood of patients with parasitic diseases were preincubated in the presence or absence of beta-interferon (beta-IFN). The number of cells bearing IgG-Fc receptors was determined by rosette formation with chicken erythrocytes coated with IgG antibodies. beta-IFN augmented the expression of IgG-Fc receptors on the cells within 1 h incubation. Treatment of beta-IFN with heat or acid did not abolish the activity. The doses of beta-IFN needed to induce the modulations of IgG-Fc receptors could also augment the eosinophil-mediated antibody-dependent cytotoxicity (ADCC) against chicken red blood cells which resulted most pronounced when the IgG antibodies were present in suboptimal amount. These data suggest the role of beta-IFN in the host resistance to parasitic diseases, mainly in the initial phases of parasitic infestation when the specific IgG antibody levels are very low.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1986

[Computerized tomography in the assessment of soft-tissue neoplasms. Observations in 124 cases].

In order to evaluate the role of Computed Tomography (CT) in prediction of nature, staging and follow-up of soft-tissue tumors, the authors examined by CT 124 patients with soft tissue neoplasms who later underwent surgery (116 cases) or fine needle biopsy (8 cases). Comparison between CT and surgical or anatomical results showed that CT was able to correctly predict the benignancy or malignancy of the masses in 76% of cases but it was very seldom able to allow an histological prediction. On the contrary CT was found to be a very useful tool for pre-therapeutic staging and follow-up of the tumors, because it gave many diagnostic information which influenced therapeutic choices and strategies.

Adolescent↗
PubMed1984

Nocturnal prolactin secretion in carpal tunnel syndrome.

The correlation between plasma PRL levels and CTS was investigated in 21 patients in whom a specific causal agent of CTS could not be identified. No correlation between plasma PRL levels and other clinical and neurophysiological data was detected.

Adult↗
PubMed1983

From teams to hierarchy: a short-lived innovation in a hospital for the elderly.

An institution created to deliver rehabilitative care to the elderly is the object of this discussion. Three years of careful planning had produced a facility with a unique spatial design, a 'team approach' rather paper documents the confrontation, during the first year, between this innovative plan and the realities of operation. When the study ended, reality was gaining the advantage over the plan.

Aged↗
PubMed1983

Sarcoidosis of the hand--report of two cases.

Sarcoidosis occurring as an isolated manifestation in the hand can pose a diagnostic problem. Skin, muscle, tendon sheath, and bone may be affected. The unusual clinical picture and operative findings are often misleading and malignancy may be suspected. Two cases of isolated involvement of bone and muscle are described.

Amputation, Surgical↗