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Biomedical subjects

G De Cosmo

Publications and source records attributed to G De Cosmo.

At least 37 records · Page 2Linked to original sources

[Various aspects of intensive therapy in myasthenia gravis].

Clinical experience acquired in the intensive treatment of 168 myasthenic patients after thymectomy, for respiratory insufficiency due to myasthenic or cholinergic crisis, after hormone treatment, or immediately after various forms of surgery is described. Particular attention is devoted to problems faced in respiratory care, anticholinesterasic and metabolic treatment, and in the prevention and treatment of infections.

Adolescent↗

An attempt to control cerebrospinal fluid acidosis in coma due to head injury.

The acid-base status of the arterial blood, jugular venous blood, peripheral venous blood and lumbar cerebrospinal fluid and the free amino acids in the cerebrospinal fluid have been studied in 12 patients suffering from coma due to head injury. They were given S adenosyl-methionine (10 mg/kg/day). Significant statistical differences of acid-base balance and CSF free amino acids have been obtained after the administration of te compound. The clinical and biochemical significance of the use of S adenosyl-methionine in severe brain injuries is discussed

Amino Acids↗

[Control of arterial pressure in aortic coarctation surgery].

After reporting personal experience in the pharmacological control of intraoperative hypertension in 14 patients with aortic coarctation, 7 of them treated with trimetaphan (TMF) and 2 with nitroprussiate of sodium (NPS), stress is laid on the advantages of NPS in comparison with TMF, namely as regards speed of induction, prompt reversibility of action and lesser interference with the haemodynamics of the renal and coronary circulations. Attention is also called to the collateral effects, such as reflex cardiostimulation, which may require the use of beta-blocking drugs, and cyanide-induced toxicity which demands dose limitation (0.5 mg/kg/h). NPS is considered the drug of choice in those situations which require emergency pressure control and in controlled hypotension, for which TMF was used in the past.

Adolescent↗