Biomedical subjects
G Dallabetta
Publications and source records attributed to G Dallabetta.
Preparations for AIDS vaccine evaluations. Rate of new HIV infection in a cohort of women of childbearing age in Malawi.
Explore the source record for details and available documents.
V3 loops of HIV-1 specimens from pregnant women in Malawi uniformly lack a potential N-linked glycosylation site.
Explore the source record for details and available documents.
Sexually transmitted diseases and human immunodeficiency virus. Epidemiologic synergy?
HIV infection and STDs are linked by common high risk behaviors. There is increasing evidence, however, that classic STDs and HIV infection interact in a bidirectional and mutually enhancing manner. Several prospective studies have demonstrated that STDs increase the risk of acquisition or transmission of HIV infection. Clinical studies have indicated that HIV infection may affect the clinical presentation, the clinical course, the diagnosis or the response to standard therapy of certain STD's. These studies provide compelling evidence that STD prevention and control are important strategies in HIV prevention.
HIV-1 and pregnant women: associated factors, prevalence, estimate of incidence and role in fetal wastage in central Africa.
The major goals of this study were to measure the current prevalence and estimate the annual incidence of HIV-1 infection in young pregnant women from urban Malawi, to identify factors that were associated with HIV-1 infection, and to examine adverse pregnancy outcomes. Four hundred and sixty-one consecutive pregnant women were studied when they presented for prenatal care. The overall seroprevalence for HIV-1 infection in these urban populations was 17.6% (81 out of 461) during early 1989. Based on previous seroprevalence in similar unselected pregnant women, the estimated annual incidence of HIV-1 seroconversion in urban pregnant women ranged from 3 to 4% per annum between 1985 and 1987 and from 7 to 13% between 1987 and 1989. HIV-1 infection was significantly associated with reactive syphilis serology. Reported history of sexually transmitted disease was also correlated with HIV-1 infection but was not statistically significant. Other variables, such as history of transfusion, history of tuberculosis, parity or occupation were not associated with HIV-1 infection. History of spontaneous abortion was significantly associated with reactive syphilis serology, HIV-1 infection and history of sexually transmitted disease. In logistic regression analysis, HIV-1 infection remained the only significant variable that was correlated with spontaneous abortion. This study suggests that HIV-1 infection may play a role in fetal wastage.
Gonococcal infections.
Although gonorrhea rates for the 1980s appear to have plateaued or even declined slightly in developed nations, in the developing world rates appear to be continuing to increase. In recent years, worldwide gonorrhea control efforts have been compromised by the continuing emergence of antimicrobial resistance resulting from plasmid-mediated beta-lactamase production, plasmid-mediated tetracycline resistance, and chromosomally mediated resistance to many antimicrobial agents. Intensive investigation of gonococcal physiology and structure has provided insights into gonococcal pathogenesis and epidemiology. Application of knowledge gained through basic research is being used to provide improved methods of gonorrhea diagnosis and to identify components of potential gonococcal vaccines.
Sexually transmitted diseases. Treating the whole syndrome.
Explore the source record for details and available documents.
Introduction of partner referral and treatment for control of sexually transmitted diseases in a poor Haitian community.
Focus group discussions were held with women attending slum-based antenatal clinics and with male partners of pregnant women separately to evaluate knowledge and attitudes regarding sexually transmitted diseases (STDs) and acceptability of a proposed antenatal STD screening and treatment programme, including partner management. Subsequently, antenatal women found to have a STD were asked to refer their partner(s) for STD treatment. The institution's routine procedure of internal referral to the curative center was evaluated for loss to follow-up. Focus group participants described common STD syndromes, knew that a pregnant woman could transmit a STD to her child, and knew that all sex partners needed to be treated for STDs. Discussion participants disagreed on the possibility of asymptomatic STDs and mentioned other ways of contracting STDs beside sexual transmission. The response to the proposed programme was positive. Of 331 male partners named by antenatal women who were found to have at least one STD, 101 (30%) presented at the clinic through index referral, and an additional 38 (11.5%) presented because of health worker referral. Of the 59 men sent to the curative center for care, only 26 (44%) received treatment. The study demonstrated that in Haiti, partners of antenatal STD patients can be treated without apparent adverse effects. However, internal referrals to separate treatment centres should be avoided. Following this study, education efforts have emphasized the curable nature of STDs, the threat of vertical transmission, and frequent asymptomatic presentation of STDs to promote prevention and treat more partners of STD patients.
Disease prevalence among women attending a sexually transmitted disease clinic varies with reason for visit.
Prevalence of sexually transmitted diseases (STD) and selected behavioral and demographic variables were evaluated in 279 women attending a Baltimore STD clinic, using a standardized questionnaire and cultures for Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis. Stratified by reason for clinic visit, 102 (37%) of 279 women attending the clinic stated that they were recent contacts to men with STDs with the majority (59 out of 102, or 58%) reporting gonorrhea contact as their reason for visit. Another 124 women (44%) came to the clinic for symptom evaluation, and 53 (19%) for other reasons. Prevalence of STDs was higher among those attending as contacts than among noncontacts: 35% versus 15% for N. gonorrhoeae; 26% versus 16% for C. trachomatis; and 27% versus 15% for T. vaginalis (P less than 0.05 for each). Furthermore, multiple infections were found in 23% of those attending as contacts but only in 10% of noncontacts (P less than 0.001). In general, patients reporting contact with an infected person were also less likely to report symptoms (43% versus 34%, P less than 0.001), despite increased disease prevalence. These data suggest that multiple STDs are often present in women attending STD clinics, irrespective of reason for visit. Merely treating women for reported exposure without further evaluation will fail to identify a substantial number of women coinfected with other organisms.
Improving reproductive health: integrating STD and contraceptive services.
The International Conference on Population and Development held in Cairo in 1994 recommended that family planning (FP) services be expanded, with more attention given to the prevention and treatment of sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV). Although such integration of FP and STD services seems a natural union, historical, philosophical, and structural differences in the two fields pose obstacles to integration in many settings. This paper examines selected experiences with FP/STD integration in the United States and developing countries and reviews practical issues that have application to FP providers, STD prevention programs, and those in general practice. Priority areas for future research include: 1) the usefulness and uses of STD risk assessment in FP populations, 2) the relationship between STD/HIV transmission and use of various contraceptive methods, 3) the feasibility of getting high-risk individuals to use dual methods for pregnancy and STD prevention, and 4) the impact adding STD services will have on training requirements, clinic costs, and quality of care within established FP programs. As clinicians in public and private settings assume more comprehensive roles in the provision of both types of services, program managers can facilitate the process of FP and STD service integration by promoting a focus on meeting the client's reproductive health needs.