[Syncopal headache. New guidelines].
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Biomedical subjects
Publications and source records attributed to G D'Attoma.
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Haemodynamic balance was assessed in relation to platelet-vessel homeostasis in the microcirculation in a group of 15 migraine sufferers and 15 healthy subjects. The results support the hypothesis of a relationship between the typical recurrence of migraine attacks and the chronobiological performance of the haemodynamic balance.
Haemodynamic balance and the circadian rhythm of plasmatic 5HT were studied in 15 migraine sufferers (common and classic). Haemodynamic imbalance and a clear desynchronisation of the 5HT acrophase was discovered. It is thought that these two elements are correlated and represent a key to the recurrence of migraine attacks.
Fifteen migraine sufferers and a control group were checked for the circadian rhythm of urinary catecholamine and VMA excretion. These data were compared with the typical variations in haemodynamic balance already encountered in migraine sufferers. It is felt that this connection is an essential element in the pathogenesis of headaches.
A preventive pharmacological treatment in 50 migraine sufferers was carried out, using the data obtained from a computerized analysis of symptoms relative, to the patients' neurotransmitter balance. The results can be considered really interesting.
Basal and throughout-the-day variations of B-lipotropin (BLPH), B-endorphin (BEP), ACTH and cortisol plasma levels were studied in seven prepubertal children who had been affected by common migraine for periods of 6-26 months and in six healthy volunteers. Despite normal cortisol concentrations, children with migraine show higher BLPH (15.1 +/- 2.7 fmol/ml, M +/- SE), ACTH (25 +/- 2.7) and BEP (9.1 +/- 1.1) levels than controls. In both groups of children, evening values (8 p.m.) were significantly lower than morning values, but in migraineurs the decrease of the three peptides was less. The raised proopiocortin-related peptide plasma levels found in children suffering from migraine cannot be explained at present, although the discomfort experienced by the patients may create a situation of chronic stress which could explain such a finding. Whatever the explanation is, these findings differentiate prepubertal migraine from the most severe forms of headache occurring in adult life where lower than normal opioid levels have been demonstrated.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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