Search PubMed⌕ Search

Biomedical subjects

G D Silverberg

Publications and source records attributed to G D Silverberg.

At least 55 records · Page 3Linked to original sources
PubMed1980

Third ventricular choroid plexus arteriovenous malformation simulating a colloid cyst. Case report.

A case of a cystic encapsulated arteriovenous malformation arising from the tela choroidea of the third ventricle is reported. Although the appearance of this lesion on computerized tomography scan suggested a colloid cyst by its location, it was atypical because of the non-homogeneity both before and after contrast infusion. The increased density on the unenhanced scan was due to hemosiderin pigment in the capsule wall caused by old hemorrhage. The diagnosis in this case was made by histological examination.

Brain Diseases↗
PubMed1980

Operative treatment of a giant cerebral artery aneurysm with hypothermia and circulatory arrest: report of a case.

A patient with a giant left middle cerebral artery aneurysm is presented. Because of previous operations and dense adhesions of the dominant frontal and temporal lobes to the aneurysm sac, we elected to obliterate the aneurysm by endaneurysmorrhaphy with the patient under hypothermia and cardiac arrest. Elective cardiac arrest has become a relatively safe, controllable procedure and may be of significant value in the treatment of difficult neurosurgical problems.

Adult↗
PubMed1979

Time course of serotonin-induced vasoconstriction.

Canine cerebral arterial segments tested in a tissue bath were found to escape from the vasoconstrictor effects of serotonin, the basilar segments more rapidly than the middle cerebral segments. At low doses (10(-9) M), serotonin caused a small, prolonged contraction, whereas at higher doses (10(-6) M), a more forceful phasic response was seen. Verapamil blocked the phasic portion of the response but not the low amplitude sustained portion. Increasing the bath concentration of K+, Ba++, and tetraethylammonium markedly enhanced the constrictor response of low serotonin doses and significantly inhibited escape. Potentiation of the force and duration of vasoactive amine-induced arterial constriction by small increments of extracellular K+ might be important in the prolonged vascular narrowing associated with subarachnoid hemorrhage.

Animals↗
PubMed1979

Epidural measurement of intracranial pressure.

Although the measurement of intracranial pressure (ICP) is gaining widespread acceptance, the most desirable method of measurement is disputed. Subdural fluid-coupled techniques are associated with an increased risk of infection, and epidural techniques are associated with decreased accuracy. We investigated epidural measurement techniques and suggest that the necessary and sufficient criteria for accurate epidural measurement of ICP are adequate transducer size and stiffness, transducer-dura coplanarity, transducer-guard ring coplanarity, complete dural contact, and rigid fixation. An epidural transducer design was developed and prototypes were constructed using these principles. The transducer requires no percutaneous connections, fluid coupling, or batteries. Transducer accuracy was +/- 2.2 torr in bench stability studies lasting up to 198 days, +/- 3.0 torr in acute animal studies of less than 24 hours, and +/- 7.9 torr in chronic animal studies lasting up to 112 days. Error bounds are expressed such that 95% of individual measurements are expected to have error less than the bound; average error is one-third of the bound. Average transducer drift was 0.1 torr per day; our reported accuracy in chronic studies used drift correction from preimplantation data. We conclude that accurate measurement of ICP using an epidural transducer is feasible.

Animals↗
PubMed1979

Anterior fibular strut graft in neoplastic disease of the cervical spine.

An anterior operative procedure using a strut of fibular graft material was performed either alone or in combination with a posterior stabilization in five patients with cervical spine instability secondary to neoplastic disease. Osseous tumor was present in four of the five patients (osteoblastoma, metastatic adrenal carcinoma, metastatic renal cell carcinoma, multiple myeloma) and the fifth had spine instability as a result of a posterior decompression for cervical spinal cord glioma. The anterior approach using fibula to replace diseased vertebrae and provide axial support for the neck was a valuable therapeutic modality in this group of patients, all of whom had a limited life expectancy. Cervical spine stability obtained by operative intervention led to a reduction of neck pain and maintenance of ambulation until the neoplastic condition became terminal.

Adenocarcinoma↗
PubMed1979

Transsphenoidal hypophysectomy in the treatment of metastatic breast and prostate carcinoma.

The cases of 70 consecutive patients having a transsphenoidal hypophysectomy for metastatic carcinoma of the breast or prostate are reviewed. In half of the patients with cancer of the breast an objective remission was obtained. In 30 percent of the patients with cancer of the prostate there were objective signs of tumor regression and in 75 percent there was relief of pain. The operative mortality was 1.4 percent and the morbidity of the procedure was gratifyingly small. There is some indication that hypophysectomy may be preferred to adrenalectomy in patients with hormone-responsive metastatic mammary cancer.

Adult↗
PubMed1979

Alterations in the organic compounds of vaginal secretions caused by sexual arousal.

The low-molecular weight organic constituents of human vaginal secretions from normally cycling subjects were analyzed both before and after sexual stimulation. Gas chromatography and combined gas chromatography-mass spectrometry were employed in the analyses of the secretions. Consistent increases were noted for a number of the lipid constituents of the secretions, suggesting that they are derived at least in part from the plasma and transude into the vaginal lumen during arousal. In addition, the increases in the concentrations of glycerol and stearic acid with respect to baseline levels were significant (P is equal to and less than 0.05). Compounds which are produced intravaginally appear to decrease in concentration during the arousal interval because of dilution by the transudate. No consistent qualitative changes were noted in the secretion.

Acetates↗
PubMed1978

Radiation-induced carotid artery disease.

Nine patients with atherosclerotic carotid artery disease associated with neck radiation were compared to 40 control patients. The data suggest that significant differences in age, incidence of coronary and peripheral vascular disease, elevated lipids and serum cholesterol, and the angiographic incidence of disseminated atherosclerosis justify the description of radiation-induced carotid disease as a clinical entity. Elevated serum cholesterol and hyperlipidemia may contribute to the development of radiation-induced vascular disease. Successful surgical reconstruction does not appear to be influenced by the prior radiotherapy, although periarterial fibrosis and increased difficulty in separating the plaques from the vascular media was encountered.

Adult↗
PubMed1978

Percutaneous radio-frequency rhizotomy in the treatment of trigeminal neuralgia.

A percutaneous technique of selective partial trigeminal root coagulation was evaluated in the treatment of 38 patients suffering from trigeminal neuralgia, 1 patient with pain secondary to oral carcinoma and 1 patient with atypical facial pain. The pain of trigeminal neuralgia was relieved in 94.7 percent of patients. Pain was relieved in the patient with oral carcinoma, but not in the patient with atypical facial pain. There was no mortality and no permanent morbidity outside of the trigeminal nerve lesion. The procedure requires only a brief hospital stay without the time, expense and hazards of open cranial surgical procedures.

Adult↗
PubMed1978

Telemetry of intracranial pressure.

In the care of patients with abnormal intracranial pressure, it is important to continuously and accurately measure the intracranial pressure so that treatment can be instituted. Strain gage pressure cells have successfully replaced the open-end manometer for chronic use but have lacked the stability for accurate long-term measurements. The system described uses a capacitive pressure transducer with excellent long-term stability. The transducer, electronics, and transmitter package can be implanted to telemeter the pressure transcutaneously, reducing the danger of infection by the elimination of transcutaneous leads. The pressure modulates the frequency of an oscillator in the 8-10 MHz region and provides an easily telemetered signal. To eliminate the problems of periodic battery replacement, the system is energized inductively by a coil placed externally over the implant device, so that the operating life is virtually unlimited.

Animals↗
PubMed1977

Hypophysectomy in the treatment of disseminated prostate carcinoma.

Seventeen patients suffering severe pain secondary to disseminated prostate cancer were subjected to hypophysectomy. Prolonged remission of pain and increased survival duration appeared to be consequent to obtaining objective signs of tumor regression. Patients who had only subjective improvement had significantly shorter periods of remission and survival. Patients with hematocrits less than 30% and patients demonstrating evidence of liver involvement did not obtain objective remissions.

Aged↗
PubMed1977

A physiological sealant for cerebrospinal fluid leaks.

A combination of concentrated platelets, thrombin, and fibronogen was used to adhere a pericranial graft to surgically produced cerebrospinal fuild (CSF) fistulas in dogs. This sealant successfully stopped leakage of CSF in all fistulas produced in both acute and chronic preparations. All control animals leaked CSF acutely. In chronic control animals the CSF leaks sealed spontaneously but the grafts were not well incorporated. Histoligical examination of the grafts and underlying brain showed not injury to the brain of meningeal vessel from exposure to the platelet glue. Good fibrous union of the grafts to the dura was confirmed.

Animals↗