Search PubMed⌕ Search

Biomedical subjects

G D Perkin

Publications and source records attributed to G D Perkin.

At least 19 recordsLinked to original sources
PubMed1991

Optic neuritis.

Explore the source record for details and available documents.

Humans↗
PubMed1989

An analysis of 7836 successive new outpatient referrals.

An analysis has been performed of 7836 successive new outpatient referrals seen by one consultant neurologist. In approximately a quarter of the patients, a specific diagnosis was not possible. A further 30% of the total was accounted for by epilepsy, tension headache, cerebrovascular disease and migraine.

Ambulatory Care↗
PubMed1989

The association of hemifacial spasm and facial pain.

The recognition of an association between trigeminal neuralgia and ipsilateral hemifacial spasm has been delayed by confusion over the nomenclature of the two conditions. Three patients are presented who had facial pain associated with hemifacial spasm. The findings on investigation of these patients, and an analysis of the literature, suggests that the combination is almost inevitably associated with pathological processes in the posterior fossa, particularly anomalous, ectatic or aneurysmal blood vessels.

Facial Muscles↗
PubMed1989

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.

To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.

Acute Disease↗
PubMed1987

T lymphocyte-derived demyelinating activity in multiple sclerosis patients in relapse.

Supernatants of cultured T lymphocytes of multiple sclerosis patients were tested for a demyelinating activity in rat cerebellum explant cultures. Supernatants of unstimulated T lymphocytes in seven out of 10 multiple sclerosis patients in relapse produced demyelination when checked by phase contrast microscopy. Supernatants of unstimulated T lymphocytes from healthy subjects did not produce demyelination, but when T cells were stimulated by phytohaemagglutinin (PHA), 50% of tested supernatants produced demyelination, which was, however, never as advanced as in multiple sclerosis supernatant treated cerebellum cultures. The demyelinating activity proved to be heat labile. Gel filtration study revealed two fractions of the demyelinating activity 12.5-29.0 kD and 43.0-66.0 kD. The results suggest that lymphokines can be directly involved in the pathogenesis of demyelination in multiple sclerosis.

Adult↗
PubMed1987

A critique of steroid trials in multiple sclerosis.

A review has been performed of the trials of steroids in MS published between 1958 and 1970. None of the trials concerned with the long-term treatment of the disease, whether with ACTH or oral steroids, revealed any benefit. Some advantage of steroids over placebo in accelerating the recovery of acute exacerbations can be claimed, though in no study has the gain been substantial.

Adrenocorticotropic Hormone↗
PubMed1987

Neurological morbidity of arch and carotid arteriography in cerebrovascular disease. The influence of contrast medium and radiologist.

A prospective study of 230 arch and carotid arteriograms in 229 patients with symptomatic cerebrovascular disease revealed that neurological morbidity was not significantly affected by patient age, nature of neurological symptoms, duration of procedure, volume of contrast medium or degree of arterial stenosis. The total neurological morbidity of 132 examinations carried out with non-ionic contrast medium (iohexol) was slightly lower than that of 98 examinations carried out with ionic contrast medium (meglumine and sodium iothalamate) but the difference was not statistically significant. However, the morbidity of 185 examinations performed by an experienced vascular radiologist was significantly lower (p less than 0.025) than the morbidity of 45 examinations performed by a series of radiologists in training and the mean time required for the procedure was 18 min longer in the latter group (p less than 0.001). These findings suggest that the neurological morbidity of arch and carotid arteriography in patients with cerebrovascular disease depends largely upon catheter technique and will not be significantly reduced by the use of non-ionic contrast medium.

Cerebral Angiography↗
PubMed1986

Neurological manifestations of the hyperventilation syndrome.

Seventy-eight patients with the hyperventilation syndrome are described, none of whom had been diagnosed prior to referral for neurological assessment. There is a constellation of symptoms associated with this condition, and attacks need to be reproduced by hyperventilation in order for the diagnosis to be established. Loss of consciousness and paraesthesiae were more frequent than in previously published series.

Adolescent↗
PubMed1986

Pattern of neurological outpatient practice: implications for undergraduate and postgraduate training.

A case analysis has been performed on 4000 successive outpatient referrals to one consultant neurologist, representing 72% of all referrals to Charing Cross Hospital and 82% to Hillingdon Hospital. A specific diagnosis was not possible in 1013 patients (25.3%). Amongst the remainder certain diagnoses were predictably common: for example, migraine (241), tension headaches (296) and epilepsy (470). Based on data obtained for the incidence of various neurological disorders in the community, an attempt has been made to assess what proportion of patients with certain diagnoses are likely to be seen by a neurologist. The rarity with which certain classical conditions, for example syringomyelia, is encountered is stressed and the implications for teaching discussed.

Education, Medical, Graduate↗
PubMed1986

Multiple sclerosis: increased expression of interleukin-2 receptors on lymphocytes.

The percentage of interleukin-2-receptor-positive peripheral blood lymphocytes in MS patients was significantly higher in acute relapse than in remission or in controls. After stimulation by phytohemagglutinin, the expression of interleukin-2 receptor on peripheral blood lymphocytes of MS patients was within the range of healthy controls, implying no general impairment of receptor expression. These results confirm other evidence that there is a small population of activated T lymphocytes in acute relapse of MS.

Adult↗
PubMed1985

Prognosis in Guillain-Barré syndrome.

The case-records of 71 patients from previous therapeutic trials were used to determine features in clinical presentation that might be useful in predicting the outcome of the Guillain-Barré syndrome. The major features adversely affecting prognosis were severe maximum deficit requiring ventilation and failure to improve within 3 weeks of reaching peak deficit. The risk of poor outcome in a patient who required ventilation and failed to improve within 3 weeks was 86%.

Activities of Daily Living↗