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Biomedical subjects

G D Dunn

Publications and source records attributed to G D Dunn.

At least 37 records · Page 2Linked to original sources

Large hypopharyngeal polyp producing intermittent dysphagia and acute airway obstruction.

A 65-yr-old man who developed sudden respiratory arrest was found to have a long, smooth, esophageal filling defect on esophagogram. Endoscopy eventually proved this to be a large esophageal polypoid lesion that had arisen in the hypopharynx and extended to the midesophagus. He was successfully treated with a lateral pharyngotomy and excision of the hypopharyngeal polyp.

Aged↗

Intramucosal gastric carcinoma in a patient with familial polyposis coli.

Upper gastrointestinal polyps commonly occur in patients with familial polyposis coli; but the occurrence of gastric carcinoma is very rare in this disorder. We report a case of intramucosal gastric carcinoma in a patient with familial polyposis coli and multiple gastrointestinal adenomatous polyps.

Adenocarcinoma↗

Primary sclerosing cholangitis associated with massive intraabdominal lymphadenopathy.

A 40-year-old man with a history of insulin-dependent diabetes mellitus was admitted to the hospital because of jaundice and pruritus. During his evaluation the diagnosis of primary sclerosing cholangitis and "microscopic" ulcerative colitis were established. Massive intraabdominal lymphadenopathy was discovered on CT scan and histological examination eventually proved this to be follicular hyperplasia. The case herein reported documents the association of primary sclerosing cholangitis with diabetes mellitus and ulcerative colitis as well as reporting the occurrence of massive intraabdominal lymphadenopathy.

Abdomen↗

Malignant fibrous histiocytoma of the liver.

A 59-yr-old man was admitted to the hospital for evaluation of right upper quadrant pain, anorexia, weight loss, and low-grade fever of 2-mo duration. During his evaluation, an abnormal liver ultrasound and computed tomography scan demonstrated what proved to be an avascular hepatic lesion. At surgery, the diagnosis of malignant fibrous histiocytoma was established. We present herein our findings of what we believe to be the first reported study of malignant fibrous histiocytoma of the liver.

Histiocytoma, Benign Fibrous↗

Primary sclerosing cholangitis.

Primary sclerosing cholangitis is a chronic, cholestatic disease affecting the biliary tree. Recent data suggest an autoimmune etiology. Clinical findings, roentgenographic characteristics, and compatible liver histology will help in establishing the diagnosis. There is no known treatment for cure, though relief of symptoms may be accomplished with certain drugs, such as antibiotics for cholangitis and cholestyramine for pruritus. Death usually ensues within five to seven years after diagnosis, as a consequence of liver failure, cholangitis, and cholangiocarcinoma.

Adult↗

Variceal bleeding from an ileostomy stoma.

Patients with portal hypertension due to cirrhosis commonly have bleeding from varices. In patients with a total colectomy, ileal varices can be a site of bleeding in cases of portal hypertension. Proper diagnosis requires studying the venous phase of the mesenteric arteriogram to show ileal varices, and carefully inspecting the mucocutaneous region of the ileal stoma for venous bleeding sites. Bleeding from ileal varices can be managed by either local control or portal vein decompression.

Hemorrhage↗

Colonic lipomas: clinical significance and management.

Colonic lipomas are uncommon tumors but do constitute the most common nonepithelial tumor of the gastrointestinal tract. They tend to occur in an older population and rarely cause symptoms. However, if a lipoma discovered by barium enema or colonoscopy is causing symptoms of obstruction or bleeding, the tumors may require surgical removal. Rarely, as in our patient, the bleeding lipoma may be sufficiently pedunculated to allow safe colonoscopic removal. In general, lipomas of the colon are curiosities that must be distinguished from adenomatous polyps.

Aged↗

Merkel cell tumor with liver metastases: presentation as fulminant hepatic failure.

This report demonstrates that hepatic metastases can present with fulminant hepatic failure and that liver enzyme abnormalities may not become prominent until there has been massive replacement of the liver. The CT scan of liver may not demonstrate diffuse liver metastases as seen in this patient. Merkel cell tumor or trabecular neuroendocrine skin tumor is a previously unreported cause for the development of the syndrome of hepatic failure due to liver metastases.

Adenocarcinoma↗

Intraluminal duodenal diverticulum.

A 46-year-old woman was seen for evaluation of dyspepsia of 8-wk duration. X-rays of the upper gastrointestinal tract revealed an intraluminally projecting diverticulum of the duodenal bulb. Diagnostic features and management of intraluminal duodenal diverticulum are reviewed.

Duodenal Obstruction↗

De novo carcinoma of the rectum: a case report.

There is strong evidence in the literature to suggest that most of the colorectal carcinomas arise from adenomatous polyps. Yet, rare carcinomas may arise de novo and we are reporting such a case of intramucosal rectal carcinoma occurring in a 47-year-old healthy man.

Adenocarcinoma↗