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Biomedical subjects

G Cusumano

Publications and source records attributed to G Cusumano.

22 records · Page 2Linked to original sources
PubMed1977

Annual and daily changes in brain serotonin content in differentially housed mice.

The annual and daily variations of brain serotonin and 5-hydroxyindolacetic acid have been studied over a 6-year period in normally grouped and isolated mice. The results obtained indicate that differences exist between normally grouped and isolated animals, especially when referred to the annual changes to which brain serotonin and 5-hydroxyindolacetic acid undergo. The results suggest that the outcome of the experiments on neurochemistry, neuropharmacology and behavior can change according to the month of the year and they can further be modified by differential housing of mice.

Animals↗
PubMed1977

Prolonged isolation and alcohol effect on avoidance learning in two strains of mice.

Prolonged isolation in mice is known to induce several behavioral changes, among which impairment of learning was also reported. On the other hand, alcohol is known to have either stimulant or depressant effects on behavior. Further, alcohol effect is also known to depend on strain-linked characteristics and on emotional ground of animals. Since prolonged isolation may differently change the emotional setting of mice, according to the strain, the behavioral effects of alcohol on avoidance learning, have been studied in two strains of male mice differentially housed. Evidences were obtained that ethanol can either improve or worsen learning performances according to the strain and the housing conditions adopted.

Administration, Oral↗
PubMedDate not supplied

Prolactin (PRL) inhibiting substance in seminal plasma of infertile patients. Preliminary results.

The role of PRL in the control of the mechanisms of regulation of testicular function is still unclear. Indeed, hyperprolactinemia is usually associated with male hypofertility. Several studies have demonstrated that human seminal plasma (HSP) contains radioimmunoassayble PRL and than testis and prostate possess membrane receptors for PRL (Charreau et al. 1977; Aragona et al. 1977). Recently Demoulin and Franchimont have observed, in HSP, the presence of a substance capable of inhibiting PRL secretion by isolated rat pituitary cells (Demoulin et al. 1978). They abbreviated it SPIF (seminal plasma PRL inhibiting factor). The inhibition of PRL secretion was significant for concentrations equal to or higher than 4.2 l of HSP/ml of culture medium. This non steroidal substance is thermostable and trypsin resistant; the molecular weight is less than 10,000 Daltons. In this work, we have compared the SPIF activity with basal levels of LH, FSH, PRL, Testosterone and, after stimulation, in the serum of patients affected with various fertility problems.

Adult↗