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Biomedical subjects

G Cumming

Publications and source records attributed to G Cumming.

At least 73 records · Page 4Linked to original sources
PubMed1977

Treatment of pulmonary aspergillosis with di-iodohydroxyquinoline.

Thirteen patients with a clinical diagnosis of pulmonary aspergillosis were treated with the anti-amoebic drug di-iodohydroxyquinoline, 1500-1800 mg/day orally, for 20 days. All were precipitin positive before treatment and all but one became negative after treatment. Sputum became negative in all of the 10 patients in whom it had been positive before treatment. Clinical improvement was marked in four patients, moderate in three, and slight in three, no change occurring in the remaining three. These results suggest that di-iodohydroxyquinoline may be of value in the treatment of pulmonary aspergillosis.

Adult↗
PubMed1977

Role of conducting airways in partial separation of inhaled gas mixtures.

A positive (hollow) cast of the bronchial tree was made from a pig's lung. Gas mixtures containing sulfur hexafluoride (SF6) and helium (He), and SF6 and argon (Ar), were blown down the cast at two different flows, the cast having first been filled with air. Gas was sampled by a mass spectrometer probe from 1-mm-diam branches situated on short, medium, and long pathways. The front of the SF6 appeared in advance of the fronts of the He and the Ar. This relative advancement was greater a) with the SF6/He mixture than with the SF6/Ar mixture; b) at slower flows; and c) on longer pathways. With reverse flow up the cast using SF6/He there was little differences between the arrival times of the two gas fronts at either flow. These results could be explained by the effects of Taylor dispersion on gases having different diffusion coefficients.

Animals↗
PubMed1976

Diameter, length and branching ratios in the bronchial tree.

This paper is concerned with morphology and pattern of branching in the bronchial tree and their interrelationships. Branching ratio (Rb), diameter ratio (Rd), and length ratio (R1) are the factors by which the number of branches, mean diameter and mean length increase in successive orders of branching. An analysis based on the concept of minimum work suggests that ideally Rd = R1/3 b, whilst geometric considerations suggest that R1 = R1/3 b. Thus Rd = R1. These theoretical results are compared with those obtained from measuring one human and six dog bronchial tree casts. Values obtained from the human lung are in close agreement with the predicted values, whilst in the dog lungs the agreement, though less good, is still close. Rb is determined antenatally, the reason for its particular value being unknown. Diameter and length of branches may be modelled postnatally by growth in a manner which ensures that Rd = R1 - R1/3 b.

Animals↗
PubMed1976

The upper limb-cardiovascular syndrome, (Holt-Oram syndrome).

Two families recently studied demonstrate the variability of expression of upper limb-cardiovascular syndrome. Four other patients with upper limb and cardiac anomalies and no significant family history may represent spontaneous mutations or examples impenetrance in antecedent generations, rather than phenocopies of the syndrome. Children under the care of the orthopedist for congenital anomalies of the upper limb should have a complete cardiac assessment.

Abnormalities, Multiple↗