Search PubMed⌕ Search

Biomedical subjects

G Csaba

Publications and source records attributed to G Csaba.

At least 505 records · Page 28Linked to original sources
PubMed1976

Cilia-forming potentials of endocrine organs originating from the foregut.

Cilia were found in intracellular localizations or on the surface of certain cells of frog thymus and chicken parathyroid gland and ultimobranchial body. The experimental observations suggest that ciliogenesis is probably a general property of branchiogenic epithelium, which either persists, or can be activated by certain influences after the functional differentiation of endocrine organs arising from the foregut.

Animals↗
PubMed1976

Effect of TSH and melatonin on thyroid activity in the rat.

Melatonin and TSH, injected separately, caused no change of the blood thyroxine level at 30 min after treatment. Simultaneous or subsequent administration of the two hormones induced an increase of the level. Thus, melatonin is capable of potentiating acute, thyroxine mobilizing effect of TSH.

Animals↗
PubMed1976

Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena.

Epinephrine, insulin, glucagon and theophylline produced a significant increase in the cAMP level of Tetrahymena, while the enhancing effect of TSH was not significant. The experimental results suggest that Tetrahymena possesses receptors for hormones of higher animals, but has no receptor for the nonsense hormone TSH. The cAMP enhancing effect shown by many hormones of higher animals irrespective of their different functions indicates that apart from the general mediator action of cAMP, some special mediation is also taking place.

Animals↗
PubMed1975

Effect of insulin on the glucose uptake of protozoa.

Insulin stimulates the glucose uptake of Tetrahymena pyriformis. This shows the presence of insulin receptors in Tetrahymena, consequently receptors may be present in a level of phylogenesis, where the natural contact between the given hormone and the cell is unnecessary and impossible.

Animals↗
PubMed1975

Observations of age and environmental influences on the thymus kept in tissue culture.

In tissue cultures of thymus of rats of various ages only the cells of Gomori- and PAS-positivity showed iodine incorporation as demonstrated by radioautography. Above other cells of the migration zone no grains indicating iodine accumulation were observable. The capacity of iodine accumulation depends on the age of the animal, namely it decreases with the ageing.

Aging↗
PubMed1975

Iodine accumulating ability as generalized porperty of cells of endodermal origin.

Embryonal trachea transplanted in the spleen of adult rats accumulates iodine. The uptake of iodine does not take place in all of the cells, but iodination centers develop and the iodinated cells detach themselves to the lumen thus resembling the holocrine secreation; The results of these experiments indicate that the uptake of iodine appears to be a generalized property of the endoderm.

Animals↗
PubMed1975

Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body.

Extirpation of the pineal body of newborn rats was followed by the disorganization of thymic structure, follicular transformation and proliferation, viz. malignant transformation of its epithelial and connective tissue elements. Increase of connective tissue was also observed in the thyroid gland. The follicular cells contained crystal-like bodies and vesicles, whereas in the parafollicular cells the endoplasmic reticulum was increased and light granules appeared.

Animals↗
PubMed1975

Collaboration of serotonin and melatonin in the control of thyroid function.

The stimulatory effect of serotonin and the inhibitory effect of melatonin on iodine incorporation by thyroid follicular cells are both inhibited by the serotonin antagonists methysergid and cyphroheptadine. Serotonin and melatonin can mutually prevent each other's action. A collaboration of melatonin and serotonin in the regulation of thyroid function is implied from the experimental observations.

Animals↗
PubMed1975

Influence of maternal thymectomy on development of the offspring in the rat.

Average body weight of the offspring of thymectomized mother rats is significantly less than normal at the age of 17-20 days. At other ages the difference is less pronounced. Though the mortality rate of such offspring seemed to be doubled, the difference was not significant. As compared to the controls, the sham operation itself decreased the thymus weight.

Analysis of Variance↗
PubMed1975

A thymic factor increasing the blood sugar level.

The thymus extract prepared by using isotonic NaC1 solution causes hyperglycaemy and the thymectomy, too, produces the same effect. Consequently, the active substance of the thymus is produced elsewhere in the organism and being stored within the thymus, gets into the extract by homogenizing its cells. Both the thymectomy and the thymic factor increase the effect of alloxan and this sensitizing effect can be prevented by pretreatment with prednisolone.

Alloxan↗
PubMed1975

3H-tyrosin incorporation by foregut entoderm, as an additional proof of extra-glandular presence of endocrine ptoencies.

Atopic transplants of embryonic rat larynx, trachea, and oesophagus incorporated 3H-tyrosine selectively and of similar degree to like transplants of thyroid. Further to similar observations with radioiodine, this finding supports the conclusion that primordial endocrinic potencies are retained, and can be activated, in a broader range of foregut derivatives than implied from the actual functional manifestations.

Animals↗
PubMed1975

Selective 5-HT uptake by epithelial cells of the rat lung.

Some of the epithelial cells of the rat lung take up serotonin from the circulation whereas the precursor of serotonin, 5--HTP, or histamine and histidine are not taken up. The observations raise the possibility that serotonin accumulation could be a manifestation of the general potentials of the entoderm.

Animals↗
PubMed1975

Blood glucose and insulin levels in thymectomized rats.

The rise of blood glucose level under sugar load was much greater in thymectomized than in normal rats, whereas the insulin level remained practically unchanged. This suggests that the rise of blood sugar level is due to two factors, one being the accumulation in blood of a substance, corresponding to the blood glucose level stimulator stored in the thymus, the other the simultaneous inhibition of insulin production, or of insulin transport, into blood.

Animals↗