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Biomedical subjects

G Corssen

Publications and source records attributed to G Corssen.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Further studies of the neural mechanisms of ketamine-induced anesthesia in the rhesus monkey.

Bipolar stimulation of tooth pulp was used to elicit evoked potentials in the cortex, thalamus, and midbrain reticular formation (MBRF) of 4 monkeys. Averaged evoked potentials in MBRF and medial thalamic nuclei were either completely obliterated or markedly reduced in amplitude by anesthetic dosages of ketamine. In contrast, little effect was observed upon the primary response elicited in the ventrobasal complex of the thalamus. These results suggest that anesthetic doses of ketamine block afferent signals concerned with the affective-emotional components of pain perception, but conduction of signals related to the localization of somatic stimuli in time and space may be relatively unimpaired.

Anesthesia↗
PubMedDate not supplied

A physiologic analysis of cardiopulmonary responses to ketamine anesthesia in noncardiac patients.

In 16 adult patients, IV ketamine, 2.2 mg/kg body weight, did not produce dramatic effects on left heart function or systemic circulation. Minute O2 consumption and O2 delivery were stable. An appreciable elevation in pulmonary vascular resistance occurred which secondarily increased right heart work. Total intrapulmonary shunt initially increased; however, the effect was short lived and did not cause clinical alterations in PaO2. The authors conclude that physiologic alterations associated with ketamine are more pronounced on the pulmonary than on the systemic vascular bed, and to the right rather than to the left side of the heart.

Adult↗