[Statistical relation between cancer and atherosclerosis. Study on 2,500 autopsies].
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Biomedical subjects
Publications and source records attributed to G Chomette.
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One case of bronchial carcinoma in which a muscular metastasis was the presenting symptom is reported. Clinical features included pain and gradual swelling of left musculus supra-spinatus. Surgical biopsy showed intra-muscular metastasis of bronchial origin. Radiotherapy provided transient pain relief, but the patient died 15 months after the first symptoms. Metastatic tumors of skeletal muscles are found in some cases, when carefully searched for in routine autopsy surveys. Most of these tumors remain asymptomatic; in other cases clinical picture includes pain, swelling and diffuse or nodular induration of the involved muscles. Biopsy shows metastatic tumor in these muscles, which generally retains the same growth pattern as seen in the primary tumor.
Ear cartilage has been studied by histochemistry, histoenzymology, immunofluorescence and electron microscopy in three cases of relapsing polychondritis. The most significant lesions have been observed at the cellular level, both by enzymology and electron microscopy : chondrocytes of peripheral zones seem to be first hypertrophic and then necrotic ; at the opposite, there is no correlation between histochemical and electron microscopic studies about the chondroid intercellular substance whose lesions are probably secondary to the cellular ones. A few chondrocytes are positive with antiimmunoglobulins sera (IgM and IgA) ; this fact could be a proof of the dysimmune nature of this disease.
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