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Biomedical subjects

G Chapuis

Publications and source records attributed to G Chapuis.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Diffuse digestive ganglioneuromatosis].

Discovery of intestinal ganglioneuromatosis implies the presence of the MEN IIb syndrome or, more rarely, von Recklinghausen's neurofibromatosis. The two conditions are due to dysfunction of the neural crest. This very rare intestinal pathology is illustrated by two observations. The intestinal motility disorders, due to the diffuse proliferation of the peripheral autonomous nervous system which ganglioneuromatosis represents, may have serious implications and indeed prove fatal. The etiologic role of excessive nerve growth factor production in these two entities is mentioned. The physiopathologic implications of an increase in vasoactive intestinal polypeptide, and of possible ectopic secretion of calcitonin by ganglioneuromatosis, are discussed.

Adult↗
PubMed1981

[Gardner syndrome. Genetic aspects of 7 cases in 3 families].

Gardner's syndrome, a hereditary affection of the bastoderm layers, is rarely recognized though it is seen in 8-16% of cases of colorectal polyposis. Seven cases (4 female and 3 male) of Gardner's syndrome in 3 families are presented. Six of the patients belonged to 2 families, several members of which suffered from familial polyposis; the seventh case was an isolated case of Gardner's syndrome without a family history of polyposis. Because of the high risk of malignancy in the presence of polyps, the treatment of Gardner's syndrome is identical to that of familial polyposis. Four patients underwent total colectomy and 2 simple polypectomy. One refused all treatment or monitoring. From these patients, one of the polyps excised from the rectum was found to be undergoing malignant transformation. The extracolic symptoms of this condition precede polyposis within the gut; they attract attention and thus permit early diagnosis.

Adult↗
PubMed1980

[Gardner syndrome: apropos of 3 families and 7 cases].

Gardner's syndrome, an hereditary affection of the different blastoderm layers, is rarely recognised, even though it is seen in 8-16% of cases of colorectal polyposis. The authors present 7 cases of Gardner's syndrome within 3 families: 4 female and 3 male. Six of the patients belonged to 2 families, of which several members suffered from familial polyposis; the seventh case was an isolated case of Gardner's syndrome, without a family history of polyposis. Because of the high risk of malignancy in the presence of polyps, the treatment of Gardner's syndrome is identical to that of familial polyposis, 4 patients underwent total colectomy, 2 a simple polypectomy and 1 refused all treatment or monitoring. From these patients, one of the polyps excised at the level of the rectum was found to be undergoing malignant transformation. The extra-colic manifestations of this condition precede the polyposis within the gut; they attract attention and thus permit an early diagnosis.

Abnormalities, Multiple↗
PubMed1979

[Surgical treatment of hyperlipidemia by partial ileal by-pass].

This study is composed of 7 hyperlipidaemic patients (type II, n = 4; type IV, n = 3), aged 33 to 59 years. These patients underwent a partial ileal by-pass, and the immediate post-operative period was uneventful. Six months post-operatively, serum levels of cholesterol and triglycerides were 45 and 44% of the pre-operative values. Serum electrolytes remained unchanged as well as liver function tests. In the first few days post-operatively, diarrhoea was a frequent complaint; by the 6th post-operative month, the stools numbered 2-3 per day in patients not receiving any medical treatment. Average weight loss was 6 +/- 1.3%. These preliminary results may confirm that partial ileal by-pass produces favourable metabolic changes. However, screening for late complications is to be further investigated, and the effectiveness of the operative procedure must still be evaluated.

Adult↗
PubMed1979

[Compression of the celiac trunk by the median arcuate ligament].

A relatively large series of 20 operated patients, aged 28 to 66 years, with median arcuate ligament syndrome is presented. There has been a change in the pattern of presentation of this condition in recent years. Early diagnosis can now be made with greater frequency than previously. The origin and the symptoms due to the intermittent, chronic abdominal ischaemia are discussed. The preliminary results suggest that surgical decompression is effective in inducing favourable changes in 60% of patients.

Abdomen↗
PubMed1978

[Surgical treatment of malignant thyroid neoplasms].

The classification of thyroid tumors, based on morphological and clinical aspects, makes it possible to compare the experience of several centers. The histology of the tumor and the age of the patient are the main criteria of prognosis. A differentiated tumor may become anaplastic. The therapeutic approach, which is primarily surgical, is therefore different for differentiated, medullary and anaplastic carcinomas. In the field of differentiated tumors, there are still some differences of opinion regarding the radicality of thyroidectomy and node dissection. In planning surgery, the incidence of bilateral tumor according to histological type, the pattern of primary lymphatic drainage and the risk of parathyroid insufficiency should be taken into account. The collaboration of the pathologist is essential. The results should be appreciated after a follow-up of at least 10 years.

Age Factors↗