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Biomedical subjects

G Chan

Publications and source records attributed to G Chan.

At least 109 records · Page 6Linked to original sources
PubMed1976

Gentamicin and albumin-bilirubin binding. An in vivo study.

Ten newborn infants were given gentamicin intramuscularly. Over a postinjection interval of 12 hours, no significant change occurred in the total binding capacity of serum albumin for bilirubin or in concentrations of serum bilirubin levels. There was no correlation between concentrations of serum gentamicin and the total binding capacity or serum bilirubin. This study provides in vivo data that supports recent in vitro experiments showing that gentamicin does not alter bilirubin-albumin binding.

Bilirubin↗
PubMed1976

Lipid metabolism in the neonate. I. The effects of Intralipid infusion on plasma triglyceride and free fatty acid concentrations in the neonate.

To determine the ability of the neonate to metabolize Intralipid, it was infused in a dose of 1 gm/kg of body weight over a 4-hour period to 27 infants in the first 48 hours of life. Differences in the metabolism of this lipid were related to gestational age and to weight for gestational age. Premature AGA infants of less than 33 week's gestation hydrolyzed the triglyceride to FFA more slowly than did AGA infants whose gestation was greater than 33 weeks. The SGA infants achieved very high plasma levels of triglycerides and free fatty acids during the infusion and cleared the lipid very slowly in the postinfusion period. This suggested impaired hydrolysis of the triglyceride and deficient uptake and/or utilization at a cellular level of the resulting free fatty acids in SGA infants.

Birth Weight↗
PubMed1976

Lipid metabolism in the neonate. II. The effect of Intralipid on bilirubin binding in vitro and in vivo.

The relationship between Intralipid fat emulsion and the binding of bilirubin to protein and cells was studied in vitro and in vivo. In the in vitro system, Intralipid had no beneficial effect in augmenting billirubin binding in adult whole blood. The unmetabolized Intralipid had no adverse effect on bilirubin binding in vitro. Twenty-seven neonates were infused with Intralipid (1 gm/kg) over a 4-hour period; the SGA infants achieved very high plasma concentrations of free fatty acids. When the molar ratio of free fatty acids to albumin in plasma was greater than six, the free fatty acids displaced bilirubin from albumin, resulting in the generation of free bilirubin. It is suggested that the molar ratios of free fatty acids to albumin in plasma be followed in any infant who is receiving Intralipid and that the dose of Intralipid be adjusted to maintain this ratio below six.

Bilirubin↗
PubMed1975

Retinal and post-retinal components of visual illusions.

A technique is presented permitting control of input to each hemiretina and each hemisphere, of the various elements of a visual illusion. When the retinal effects and post-retinal effects are added, the result is greater than the total illusory effect. This is believed due to the mixing between hemispheres via the corpus callosum, and suggests a possible means of assessing the role of the corpus callosum.

Corpus Callosum↗
PubMed1968

Leukemia virus suppression of antibody-forming cells: ultrastructure of infected spleens.

Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of spleen sections from infected mice with depressed immunity revealed that virus particles can be detected only in immature blastlike lymphoid cells and not in plasmocytes characteristic of the immune response in spleens of noninfected mice immunized with sheep erythrocytes.

Animals↗