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Biomedical subjects

G Cecchetti

Publications and source records attributed to G Cecchetti.

68 records · Page 4Linked to original sources
PubMedDate not supplied

Rhabdomyosarcoma presenting as acute hematologic malignancy: case report and review of the literature.

The authors describe a case of undifferentiated rhabdomyosarcoma from unknown primary site, presenting as an acute hematologic malignancy with generalized lymphadenopathy, extensive bone marrow involvement and clinical and laboratory features of disseminated intravascular coagulation. Such a peculiar behaviour is known for rhabdomyosarcoma but is rare and can be a serious diagnostic problem for the clinician and the pathologist. The importance of a large spectrum immunohistochemistry as first diagnostic approach to any undifferentiated small-cell malignant tumor is stressed, together with the knowledge of the different immunoreactivity patterns. Desmin, MS-actin and myoglobin are the most reliable markers of this type of myogenic sarcoma.

Actins↗
PubMedDate not supplied

[Sampling strategy and analytical problems in work environments].

The paper reviews the problems involved in sampling and analysis of pollutants in working environments. Special attention is given to the practical consequences of the particular working conditions of to-day, which are characterized by low levels of environmental pollution but are at the same time subject to the presence of mixtures of chemical substances. There is no doubt that the time has come to attempt to reach the greatest possible consensus on these problems (e.g., analytical procedures for complex mixtures). Guidelines and procedures are indicated for the control of indoor pollution and indoor air quality limits are proposed both for long-term (ALTER) and short-term (ASTER) exposures.

Air Pollutants, Occupational↗
PubMedDate not supplied

[Non-bioavailability of carcinogenic polycyclic aromatic hydrocarbons contained in coal dust].

The aim of the study was to ascertain whether polycyclic aromatic hydrocarbons (PAHs) especially 3,4-benzo(a)pyrene, could be eluted from coal dust that comes into contact with biological fluids or crosses the skin barrier. A fine-grained coal dust with known PAH content was placed into contact with homogenized pig lung or human gastric juices, and also applied to monkey skin, using the cutaneous window method. The results demonstrate that, in the in vitro systems used, PAHs contained in coal dust are not eluted by lung homogenate or gastric juices, nor are they capable of crossing the skin barrier. These results justify and support the interpretation given to the results of experimental carcinogenicity studies on coal dust which never succeeded in demonstrating a higher incidence of cancer, particularly lung cancer, in treated animals.

Animals↗