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Biomedical subjects

G Cassarino

Publications and source records attributed to G Cassarino.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Local-regional dental anesthesia without vasoconstrictors].

Since Braun in 1905 first associated adrenalin with Einhorn's novocaine (procaine) to augment anaesthetic action, many attempts have been made to replace this vasoconstrictor because of the often severe inconveniences it can cause (cardiovasculopathic, arteriosclerotic, etc.). Reduction in dosimetry is recalled in brief: 1-corbasil; vasopressin; nor-adrenalin. It is personally considered that none of these measures ever successfully replaced adrenalin, nor did they prove to be so harmless as was originally believed. Finally, the refinement of biochemical research enabled more powerful and less toxic locoregional anaesthetics to be marketed and these provided ideal anaesthesia without vasoconstrictors. Pure carbocaine has been personally used exclusively for more than four years, with the two-fold advantage of practically completely avoiding any general inconvenience, particularly in cardionephrotics, diabetics, etc. and, in plexic (or terminal) injections, avoiding the threat of ischaemia which is the most frequent cause of alveolitis and of secondary haemorrhage. This locoregional anaesthetic without vasoconstrictor is therefore recommended, while the vast majority of clinics continue to use anaesthetics associated wtih non-indispensable and dangerous vasoconstrictors.

Adult↗
PubMedDate not supplied

[Flucloxacillin].

The pharmacological and clinical properties of flucloxacillin, a new isoxazolilpenicillin, are reported. This drug shows a low acute and chronic toxicity, and enteric absorption clearly higher than cloxacillin and oxacillin. Its binding capability with serum proteins, though rather high, is nevertheless lower than dicloxacillin. The antibacteric activity of flucloxacillin is particularly evident in Gram-positive bacteria and above all on penicillinases producing staphylococci. Flucloxacillin has proved to have successfull effect in the clinical therapy of several infections, particularly of respiratory apparatus and soft tissues.

Animals↗