Search PubMed⌕ Search

Biomedical subjects

G Carey

Publications and source records attributed to G Carey.

41 records · Page 3Linked to original sources
PubMed1983

Extracting meaning and direction from twin data.

This paper reviews the current status of the twin method as a research tool in psychiatry. It is shown that the common practice of reporting only probandwise concordance rates leaves much of the meaning unextracted from the data, and that by including appropriate estimates of the population risk, the concordance rates can be converted into liability correlation coefficients, which can be assessed within the theoretical framework of multifactorial-threshold-polygenic disorders.

Alcoholism↗
PubMed1980

Prevalence rates for the neuroses: pitfalls in the evaluation of familiality.

A survey was made of studies reporting population prevalence rates for the different types of neurotic disorders in order to determine the utility of these rates for familial and genetic research. Rates varied considerably among studies both for all neuroses and for particular types of neuroses, even among studies using similar methods examining similar populations. The method of case ascertainment (personal interview versus record searches) and the threshold for defining an individual as affected are important contributors to variation. The use of the published prevalence rates for quantifying familial and genetic effects on the neurotic disorders would be premature.

Actuarial Analysis↗
PubMed1978

Reliability and validity in binary ratings: areas of common misunderstanding in diagnosis and symptom ratings.

Confusion may exist between the reliability of a binary rating (for example, schizophrenia versus not-schizophrenia) and its implications for validity. High reliability does not guarantee validity, but paradoxically, low reliability does not imply poor validity in all contexts. Changes in the base rate or in experimental design may indicate high validity even when the reliability was thought to be low. Attempts to improve the psychiatric nomenclature by increasing only reliability run the risk of the "attenuation paradox" where further increases in reliability will make the ratings less valid. Finally, the assumption of random error in making diagnoses does not always hold, so that statistical analyses must be adjusted accordingly. New statistical methods are needed to index only false-positive or false-negative rates in order to quantify the error that will reduce some validity coefficients.

Bipolar Disorder↗
PubMedDate not supplied

Good questions.

Explore the source record for details and available documents.

Hospital Units↗