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Biomedical subjects

G C Isaia

Publications and source records attributed to G C Isaia.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Is magnetic resonance imaging more sensitive than computed tomography in the location of corticotropin secreting pituitary adenomas?

Two cases of pituitary-dependent Cushing's syndrome are described in which the computed tomography (CT) examination was negative; as the hormone dynamic investigations were directed towards the presence of corticotropin (ACTH) secreting pituitary formations, magnetic resonance imaging (MRI) of the pituitary was performed, which evidenced the presence of such lesions; subsequent neurosurgery confirmed in both cases the location indicated by MRI. In conclusion, the higher sensitivity of MRI compared to CT in the diagnosis of ACTH secreting pituitary adenomas can be noted.

Adenoma↗
PubMedDate not supplied

[Osteoporosis: a new social disease?].

Main epidemiological studies about osteoporosis are described: the availability of sophisticated techniques as double photon absorptiometry permits to establish that in U.S.A. there is at least 1.2 million osteoporosis fractures each year, mainly at trabecular level and in postmenopausal women. Moreover the hip fractures induce a significant reduction in life expectancy (between 12% and 20%) with very important social costs. In Italy some recent data documented that the social costs in relation to osteoporosis fractures can be evaluated in 1983 between 80 and 153 milliard liras. Some data about annual bone density decrement in normal population are reported: 0.38%/year in females and 0.22%/year in males. Moreover the theoretical fracture threshold, defined as B.M.D. level 2.5 SD under the mean value founded in young age, was evaluated (0.67 gHA/cm2). Finally in 15% of our patients with more than 65 years almost one vertebral fracture was found.

Adolescent↗
PubMedDate not supplied

[Clinical problems of osteoporosis].

In this paper we summarize the main problems connected with the diagnosis of primary osteoporosis, after evidencing the remarkable social importance of the disease, linked to the great increase of aged population; finally the pathogenetic hypotheses more documented are described. From a diagnostic point of view common laboratory investigations are not mostly able to provide sufficient significant informations; recently the dosage of osteocalcin as index of osteoblastic activity and as marker of bone turnover has been suggested. Mainly traditional radiology does not provide sufficient information about the real demineralization rate, while the radiogrammometry can offer sufficiently reliable indications about bone mineral content. Of a greater diagnostic meaning can be considered the bone mineral absorptiometry and in particular the double photonic ray absorptiometry, effected at the level of lumbar spine, that is to say a side earlier affected by the osteoporotic process. With this methodology we are able to obtain precise information about the quantity of the bone mineral content, identifying, at an earlier stage, the patients at risk of osteoporosis.

Aged↗
PubMedDate not supplied

X-ray densitometry applied to the study of prenatal ossification.

To evaluate bone mass (BMC) and bone density (BMD) it is possible to utilize x-ray absorptiometry. This method is usually employed in clinical practice for the evaluation of metabolic osteopathies. The authors describe an application of this diagnostic technique to the study of the ossification pattern of the human vertebral column in pre- and post-natal life. On this regard, an ultra high resolution software allowed to analyze quantitative aspects of the ossification of small size vertebral bodies by lateral scans directly performed on bone specimens.

Absorptiometry, Photon↗
PubMedDate not supplied

[Determination of LH and FSH levels before and after prostatic adenomectomy (author's transl)].

Plasma testosterone, LH, and FSH levels were measured in 29 patients with adenoma of the prostate, before and after adenomectomy. Blood testosterone levels showed significant variations which were probably related to operation stress, as after a moderate reduction--they returned to pre-operative levels. No significant modifications in plasma LH or FSH levels were observed.

Aged↗