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Biomedical subjects

G C Cook

Publications and source records attributed to G C Cook.

At least 181 records · Page 10Linked to original sources
PubMed1975

Serum immunoglobulin and protein concentrations in Zambian African patients in Lusaka.

Serum immunoglobulins IgG, IgA, IgM and IgD and gamma-globulin, total globulin and albumin concentrations have been determined in 136 adult Zambian African hospital in-patients, with several diagnoses, in Lusaka, Zambia. The study gives base-line data for that population. A significant positive correlation between serum IgG and gamma-globulin concentrations (P less than 0.001) suggests that for routine use the less costly method for serum gamma-globulin determination gives equally useful information as that for IgG.

Adult↗
PubMed1974

Inverse relation between serum IgG concentration and glucose and xylose absorption in Zambian African adults.

In three separate investigations in Zambian African adults in Lusaka an inverse association has been shown between serum IgG concentration and either glucose absorption rate from the jejunum (from a 200-mM solution) or xylose absorption (from a 25-g oral load). In developing areas of the world, where serum IgG concentrations are often high, this finding may have widespread nutritional implications.

Adult↗
PubMed1974

Effect of glycylglycine and glycine on jejunal absorption rate of L-histidine in man in vivo.

1. Using a double-lumen tube jejunal perfusion system in vivo, the effects of glycylglycine and glycine on the jejunal transfer rate of L-histidine have been studied in a 30 cm jejunal segment, in six Zambian African men. Data on the effect of L-histidine on glycylglycine transfer rate have also been obtained. The solutions perfused in each subject contained (A) L-histidine (100 m-mole l.(-1)), (B) L-histidine (100 m-mole l.(-1)) and glycylglycine (50 m-mole l.(-1)), (C) glycylglycine (50 m-mole l.(-1)), and (D) L-histidine (100 m-mole l.(-1)) and glycine (100 m-mole l.(-1)).2. Whereas the presence of glycine in the perfusing fluid significantly impaired the absorption rate of L-histidine (P < 0.01), glycylglycine had no significant effect. The presence of L-histidine in the perfusing fluid had no significant effect on the rate of glycylglycine absorption. When compared with results for glycine absorption rate in twelve Zambian African subjects in another study, the presence of L-histidine produced a significant impairment in the rate of glycine absorption (P < 0.001).3. The results demonstrate a mutual inhibition between the rates of L-histidine and glycine absorption. The lack of a similar inhibition between L-histidine and glycylglycine is consistent with the concept of independent transfer mechanisms for amino acids and dipeptides in the human jejunum.

Adult↗
PubMed1974

Reaction of human small intestine to an intraluminal tube and its importance in jejunal perfusion studies.

A double-lumen tube with a mercury weight attached to its distal end was positioned in the small intestine of six subjects who were to undergo an elective laparotomy. The tube and the technique for its localization were exactly similar to those used in previous intestinal perfusion experiments. Marked ;concertinaing', or gathering of the small intestine proximal to the mercury weight, was seen at laparotomy in all six subjects. The ratio between the mean intestinal length from the mercury weight to the ligament of Treitz after removal of the tube to that with the tube in situ was 3.0 (2.5-3.8). Mean total jejuno-ileal length was 421 (320-521) cm. In five of the six subjects the distal end of the tube was more than half way between the ligament of Treitz and the ileo-caecal valve although it was only 100-120 (mean 108) cm from the incisor teeth. Segmental perfusion studies of the human jejunum involve a much longer length of small intestine than is generally assumed-by a factor of approximately 3. Such studies assess absorption rates over a substantial proportion of the small intestine and are not confined to a short segment of proximal jejunum. The nutritional significance of such studies in which amino acids, peptides, and carbohydrates are investigated is increased. Studies designed to measure absorption rates from the ileum should be treated with caution as part or all of the perfusion segment may be past the ileo-caecal valve.

Adult↗