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Biomedical subjects

G C Buckle

Publications and source records attributed to G C Buckle.

6 recordsLinked to original sources
PubMed1990

Blood donors with antibody to the human immunodeficiency virus--the Natal experience.

The major incursion of human immunodeficiency virus type I (HIV-1) infection into the South African heterosexual population has been by southerly migration of the heterosexual HIV-1 epidemic from central Africa. Much important information can be obtained from blood donor seroprevalence data and cohort studies of those individuals infected during the early stages of the epidemic in South Africa. By the end of April 1989, over half a million blood donors in Natal had been screened and the presence of antibody to HIV-1 confirmed in more than 200. The majority of these anti-HIV-1 positive donors are young and single (many of them still at school), although a substantial proportion already have children of their own and a recent history of sexually transmitted disease is common. The Natal Blood Transfusion Service experience indicates that the heterosexual HIV-1 epidemic in Natal is essentially no different from the earlier stages of heterosexual epidemics elsewhere in Africa. There is still time for effective programmes to have a major impact on progression of the epidemic in South Africa, particularly if these programmes are directed at the young population in educational institutions.

Adolescent↗
PubMed1979

Haematological differences in three population groups.

The increased absolute lymphocyte counts of Indians and Blacks in comparison with Whites, observed in a former study, were shown, in a study on blood donors, to occur in women rather than men of these two groups. Neutrophil counts showed no sex differences, but were significantly highest in Whites and lowest in Blacks. Indians of both sexes had significantly higher mean red cell counts, together with smaller red cells, than subjects in the other two groups. In no group was a significant correlation observed between body mass and haemoglobin level.

Black People↗
PubMedDate not supplied

Computer simulation as a method for evaluating the copper sulfate test for hemoglobin in diverse populations.

The copper sulfate hemoglobin screening method was separately evaluated for three local population groups which do not conform to accepted normal standards of hemoglobin and/or plasma specific gravity (SG). This was carried out by a computer which simulated the distribution of plasma specific gravity and hemoglobin levels in random samples of blood donors. Simulations of 1,000 were carried out for males and for females in each of the three main population groups in Natal (Caucasians, Negroes and Asians). These were compared with a simulation of hypothetical normal subjects whose hemoglobin and plasma SG conformed to accepted standards. Variations in accuracy, relating to differences in plasma specific gravity and in hemoglobin, were demonstrated. Acceptances of donors who should be rejected (Type II errors) were most common in Negroes, but did not occur in the normal group. Type II errors did not occur in males with hemoglobin levels below 12.5 gm/dl or in females under 11.5 gm/dl. Erroneous rejections of prospective donors who, in fact, satisfied the criterion of acceptance (Type I errors) occurred in all groups, but were fewest in the normal group.

Computers↗