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Biomedical subjects

G Burg

Publications and source records attributed to G Burg.

At least 469 records · Page 26Linked to original sources
PubMed1977

Morphological and functional differentiation and classification of cutaneous lymphomas.

It was the purpose of our studies to achieve reevaluation of the histo- and cytomorphology of cutaneous lymphomas by means of additional enzymecyto-chemical and funtional tests. Skin biopsy specimens from 99 patients with cutaneous lymphomas and pseudolymphomas were stained for HE, Giemsa, PAS, Gormori, several hydrolytic enzymes and peroxidase. In cell suspensions extracted from skin lesions B and T cell differentiation was performed using surface markers. In addition tissue cells were tested for PHA response in suspensions and for intracytoplasmatic Ig on smears. Based on these studies cutaneous lymphomas were filed, within the "Kiel" classification of low grade and high grade malignant lymphomas according to their histological, enzymecytochemical and immunological features. It got evident that B cell and T cell lymphomas of low grade malignancy in the skin both present distinct histological patterns, indicating areas B and T cell microenvironmental specificity.

B-Lymphocytes↗
PubMed1976

[Progress in the diagnosis of cutaneous lymphomas. Enzyme cytochemical and immunocytological studies].

The term ""cutaneous lymphoma'' is used for lymphoreticular proliferative processes which primarily affect the skin. This term includes: mycosis fungoides, Sezary-syndrome and ""pagetoid epidermotropic reticulosis''; ""malignant reticulosis'', ""reticulum cell sarcoma'' and lymphosarcoma; in a wide sense of this term pseudolymphomas (lymphadenosis benigna cutis, benign lymphocytoma), specific skin infiltrates in leukemia and Hodgkin's disease might be included as well.

Acid Phosphatase↗
PubMed1975

[T and B lymphocytes in skin changes of cutaneous lymphoma (author's transl)].

In 30 patients with benign or malignant lymphoreticular proliferation of the skin (38 skin biopsies) the percentage of immunoglobulin-bearing (B) and of spontaneous rosette-forming (T) lymphocytes was determined in cell suspension from homogenized tissue. Four main classes of cutaneous lymphoma could be differentiated: lymphocyte-rich (more than 50% of the infiltrate cells, predominantly B-lymphocytic, predominantly T-lymphocytic, mixed B and T-lymphocytic), lymphocyte-depleted (less than 50% of infiltrate cells), reticulo-histio-monocytic infiltrates, and reticulo- or lymphosarcoma. A definite statement was not possible (other than in leukaemic processes) if the accumulation of lymphocytic cells represented the primary malignant process rather than a concomitant inflammatory reaction. A clinically useful differentiation was into hyperplasia, paraplasia and neoplasia, as this takes into account different histopathological characteristics of cutaneous lymphomas (reactive hyperplastic/autonomic proliferative: benign/malignant; reversible/irreversible; systemic/nonsystemic; metastasizing/nonmetastasizing).

B-Lymphocytes↗
PubMed1975

Histographic surgery: accuracy of visual assessment of the margins of basal-cell epithelioma.

In 72 basal-cell epitheliomas, the clinical extension and the actual extension of the defect measured by complete tumor removal by Mohs' chemosurgery were compared. Subclinical extension depends on the type of basal-cell epithelioma (primary, recurrent), on case history, location, clinical diameter, number of previous treatments and histological type. It is remarkably great in large (diameter more than 20 mm), in morphea-like basal-cell epitheliomas on the forehead, temple and scalp, especially following several previous treatments. In such cases the excision should include at least a 5-10 mm margin of "normal tissue." Present results again show that "histographic," that is, Mohs' chemosurgery is the method of choice for the treatment for these tumors.

Basal Cell Carcinoma↗
PubMed1975

[Lymphoreticular proliferations in the skin. Cytochemical and immunocytological studies in lymphadenosis benigna cutis].

In 8 patients with lymphadenosis benigna cutis (LABC) cytochemical and in 2 of them immunocytological studies have been performed. 1) In patients with LABC we find ectopic organoid proliferations of "lymphfollicle"-like structures within the dermis which predominately consist of small lymphocytes and large reticulum cells. Immunocytological differentiation of the lymphocytes leads to the characterization of B- and T-lymphocytes in a ration 2:1. 2) Large reticulum cells represent a peculiarly remarkable cell class in infiltrates of LABC. Because of their typical arrangement disseminated within the lymphocytic infiltrate they have been designated as "starry sky" cells. Cytochemically they are characterized by an unusual high content of nonspecific esterases and acid phosphatase, most of them show phagocytized basophilic bodies. Because of their shape, arrangement and enzymcytochemical behaviour these cells can be referred to as typical for the LABC disease. 3) Monocytes cannot be found within the "lymphfollicles". Mast cells and connective tissue cells are rarely observed. Polymorphonuclear granulocytes can be demonstrated in great numbers in any part of the involved cutis when there is an insect bite in history. 4) As a reaction of the ectopic proliferation of lymphoreticular tissue within the dermis there is an activation of the surrounding connective tissue with an increase of the alkaline phosphatase activity within these cells, new formation of collagen fibres and strong proliferation of alkaline phosphatase positive capillaries. 5) Etiopathologically it is stressed, that in LABC for example an insect bite induces stimulation of hematopoietic potentialities of undifferentiated mesenchymal germ centres within the cutis takes place, leading to the development of ectopic of "lymphfollicle" like structures.

Acid Phosphatase↗
PubMed1975

[Sézary's syndrome. Case report].

A patient with Sézary syndrome is presented. The symptoms persisted for 5 years when a sudden involvement of internal organs led to the death of the patient. Much evidence indicates that the Sézary syndrome is a special form of mycosis fungoides with erythroderma and a constant release of atypical cells into the blood. The nature of the Sézary cell has not yet been clearly elucidated. Cytogenetic and immunological findings identified the Sézary cell as an abnormal T-lymphocyte whereas cytochemical data support the concept of the presence of different atypical cell populations with lymphocytic respectively monocytic character.

Blood Cells↗