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Biomedical subjects

G Burg

Publications and source records attributed to G Burg.

At least 433 records · Page 24Linked to original sources
PubMed1983

[Iatrogenic pseudotumor of the skin induced by polyvinyl pyrrolidone].

A 65-year-old woman developed a prominent tumor-like swelling of the skin in the face and shoulder area after having received parenteral applications of a drug containing polyvinylpyrrolidone (PVP) (Depot-Impletol) for many years. Upon first examination the alterations appeared to represent a tumor of the adipose tissue. Subsequently, however, they were shown to result from excessive storage of high-molecular fractions of PVP in the reticulohistiocytic system. Storage of these fractions of PVP, which cannot be eliminated with urine, was also found in the interstitial tissue of adjacent muscles and in local lymph nodes. The histological picture resembles a thesaurismosis. The present report also describes enzyme histochemical and electron-microscopic findings. The electron-microscopic results are similar to those described by other authors in the few ultrastructural reports of PVP storage. The ultrastructural alterations in the capillary endothelium suggest a transendothelial transport mechanism for the incorporated substance.

Aged↗
PubMed1983

[Anaphylaxis following ingestion of coffee, chronic urticaria and analgesics idiosyncrasy].

In a 45-year-old woman with chronic urticaria anaphylactoid reactions occurred after (1) ingestion of coffee and (2) taking an analgesic drug. Prick testing in the patient and passive cutaneous anaphylaxis with coffee extract in the monkey Macacus nemestrinus were positive. With regard to further prick tests and oral provocation tests there is conclusive evidence that anaphylactic hypersensitivity to coffee was co-existing with idiosyncrasy to acetylsalicylic acid, indomethacne, metamizole (dipyrone), and caffeine.

Analgesics↗
PubMed1982

Cutaneous immunoblastic T-cell lymphoma.

The case of a 69-year-old male patient with an unusual type of malignant lymphoma is presented. Clinically, it was at first characterized by follicular papules and erythematous patches, later, by the development of cutaneous tumors and enlarged lymph nodes, and by a severe, finally excruciating pruritus. Treatment with PUVA (psoralen-ultraviolet-A) combined with 40--80 mg prednisolone and then with chemotherapy [COPP regimen (cyclophosphamide, vincristine, procarbacine, prednisone), high-dosage methotrexate followed by citrovorum factor rescue] was not successful. The patient died of pneumonia 2.5 years after the onset of the first clinical symptoms. An immunoblastic infiltrate was observed histologically and electromicroscopically in the initial lesions of the skin. Therefore, the diagnosis of a cutaneous immunoblastic T-cell lymphoma was tentatively made at the beginning, which was later confirmed in numerous biopsies and laboratory investigations. Immunocytologically and enzymecytochemically, the infiltrating cells were shown to be immature T cells; in the lymph nodes, numerous immunoblasts and large Sézary cells was observed in the peripheral blood, though there were no very large Sézary cells or blast cells. In the autopsy, a systemic involvement with an atypical lymphoid infiltration was found in numerous internal organs. The special nature of this case justifies its classification as high-grade malignant lymphoma and its differentiation from normal cases of mycosis fungoides. In contrast, mycosis fungoides generally fulfils criteria typical of low-grade malignant lymphomas.

Aged↗
PubMed1982

[Frequency of contact allergy in housewives (author's transl)].

A survey was taken of 616 housewives with a total of 1405 positive reactions in the patch tests. These women belong to a group of 3300 patients who showed contact allergic reactions in the patch test during the period between 1970 and 1974. The highest rate of sensitivity was found in the group of housewives in the age group over 60. The most common allergens of the housewives have been: p-aminodiphenylamin. Peruvian balsam, lanolin alcohol. Specific differences between men and women in the allergen spectrum are the following: in men there was a strong tendency to be allergic to potassium dichromate, and in women the allergic tendency was to nickel sulphate. Among the housewives no special preference toward allergies to nickel sulphate and potassium dichromate was observed.

Adult↗
PubMed1981

Lymphomatoid papulosis: a cutaneous T-cell pseudolymphoma.

It was the purpose of this study to further define the nature of the dermal infiltrates in lymphomatoid papulosis (LP) means of enzyme cytochemistry (acid phosphatase and esterase), immunology (rosetting techniques, immunoperoxidase technique on cryostat sections), and by semithin and ultrathin sections. The studies performed on biopsy samples with clinically and histologically typical LP indicated that most lymphoid cells display markers for T-lymphocytes, which were helper T-cells in the one case studied with monoclonal antibodies. Regarding the typical benign self-involutive clinical course, LP is considered to be a cutaneous pseudolymphoma of T-cell type.

Humans↗
PubMed1981

[Dye and nickel allergy in the hairdressing salon].

In 73 hairdressers, out of a total number of 3,300 patients, patchtests were performed using substances of a standard series. Patients of various professions excluding hairdressers and patients belonging to an age group comparable with that of hairdressers, served as two control-groups. In the group of hairdressers the most frequently seen positive reactions were against p-phenylendiamin, nickelsulfat, pellidol, cobaltchlorid, p-aminodiphenylamin, and perubalsam. The incidence of positive reactions against p-phenylendiamin and pellidol in this group was significantly higher than in the control group, whereas the higher incidence of nickelsulfat allergy in hairdressers proved not to be significant.

Adult↗
PubMed1981

[High-grade malignant mycosis fungoides with cytological transformation (author's transl)].

In the Kiel-classification of non-Hodgkin lymphomas a distinction is made between low and high grade malignancy. Mycosis fungoides is listed among the low grade malignant lymphomas because in the cellular infiltrate small lymphoid cells are predominant. Two cases are reported in which the cellular infiltrate of the cutaneous lesions consists mostly of large lymphoid cells resembling lymphoblasts and immunoblasts indicating a high grade malignancy. This type of cellular infiltrate appeared as a blastic transformation from mycosis fungoides very early in one case and at a later stage in another. Clinically these two cases were characterized by a rapid progression leading to the deaths of the patients. The cytological analysis in cutaneous lesions of mycosis fungoides seems to have a prognostical and possibly a therapeutical bearing.

Adult↗
PubMed1980

[Reticulosis of the skin - a heterogenic group of diseases].

In terms "reticulosis of the skin" has been used preferentially in the German dermatological literature to designate an autonomous, irreversible, atypical, systemic proliferation of elements of the reticulohistiocytic system in the skin, different from mycosis fungoides, reactive hyperplasias (pseudolymphoma), true neoplasias (reticulo sarcoma) and storage dermatosis (histiocytosis X). They provide about 1/4 of the lymphoreticular proliferations of the skin, a frequency which is comparable with that of cutaneous T-cell-lymphomas (mycosis fungoides and Sézary's syndrome). Enzymecytochemical demonstration of hydrolytic enzymes, immunological (surface-markers for B- and T-lymphocytes, quantitative determination of tissue immunoglobulins) and electron-microscopic studies in 266 patients with lymphoreticular proliferations in the skin (65 of these were "reticuloses") have lead to the following results: 1. Most of the "reticulosis of the skin" belong to the B-cell lymphomas of low grade malignancy. 2. In the skin they show a typical histomorphological feature (B-cell-pattern of infiltrate). 3. Following the Kiel Classification further differentiation into centrocytic (36%), "immunocytic" (32%), centroblastic/centrocytic (18%) and lymphocytic (14%) lymphoma can be made. 4. "Skin-reticuloses" may represent early changes of malignant lymphoma and may precede late manifestation of systemic involvement for many years.

Diagnosis, Differential↗
PubMed1980

[Intolerance reactions following parenteral administration of vitamin B].

A report of a patient showing incompatibility following the parenteral application of a vitamin B1 containing medicament and review of the literature is given. In the case reported there was a positive pricktest with drugs containing vitamin B1. However an oral provocation test did not show any reaction.

Administration, Oral↗
PubMed1980

[Atypical fibroxanthoma].

A patient with atpical fibroxanthoma is presented. This histiocytoid tumor occurs mainly in elderly patients in light-exposed skin. Recurrences were seen in approximately 10% of all published cases, but metastases to the regional lymph nodes were noticed in 1% only.

Female↗
PubMed1980

[Diffuse congenital melanosis].

Two sisters with an unusual non-classifiable type of hyperpigmentation are presented. Clinically characteristic was the diffuse grey-brownish coloration of the skin and its presence since birth in both cases. Ultrastructurally almost no compound-melanosomes in the epidermis were noted.

Child, Preschool↗
PubMed1979

[LEOPARD syndrome].

Three cases of LEOPARD-syndrome are presented. A review of literature is given. Among the symptoms of the syndrome lentigines, ECG-abnormalities, pulmonal-stenosis, retardation of growth and deafness show the strongest penetrance and are most constantly found.

Abnormalities, Multiple↗