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Biomedical subjects

G Brun

Publications and source records attributed to G Brun.

At least 127 records · Page 7Linked to original sources
PubMed1978

Reevaluation of levodopa-propranolol as a test of growth hormone reserve in children.

The growth hormone (GH) reserve of 15 short children was evaluated with the levodopa-propranolol test (DPT) and the sequential arginine-insulin test (AIT). Four patients failed to respond to both tests and were classified as hyposomatotropic. In the other 11 children, the mean GH peak response to the DPT was significantly higher than that to the AIT, mainly because five subjects who had a normal response to the DPT failed to respond to the AIT. These children had a generally poor yearly growth increment prior to testing associated in three with an obvious emotional problem, and were found at follow-up to have resumed a normal growth pattern. These data confirm the effectiveness of the DPT as a test of GH reserve. Although hypoglycemia can occur occasionally during test, this procedure is safer and easier to perform than the widely used AIT. Finally, the DPT seems to detect a category of children who have a temporary growth failure and nonresponse to the usual GH tests but who are not hyposomatotropic and consequently do not require human GH.

Adolescent↗
PubMed1977

[About the infection of Drosophila female germ line cells by sigma virus (author's transl)].

The results which have been presented by Bregliano (1973) and Bregliano et Fleuriet (1975) in this "Annales" are discussed. The author's conclusion is that there are two distinct mechanisms for contamination of the cysts of non-stabilized females (in stabilized females, all cells, including oogonial cells, are infected in carrier state by sigma). Hypotheses are discussed.

Animals↗
PubMed1976

[The ovary after ovariotexy].

After reviewing the technique of the operation the authors report on the results of 25 cases of ovariotexy. This procedure of surrounding and placing the ovary extraperitoneally has been practised with the idea of performing a reversible sterilisation. Only 2 pregnancies resulted. 18 cases were reviewed after a certain interval of time (a mean of 2 1/2 years). 5 cases of dysmenorrhoea and 2 cases of cystic changes in the ovaries occured. 6 patients who before ovariotexy had regular cycles and were free of all symptoms and of all neuro-psychiatric treatment retained their regular cycles, controlled biologically. 6 further patients who had regular cycles but had a neuro-psychiatric history were seen of whom 4 kept to more or less regular cycles. The 6 patients who had irregular cycles did not change their cycles, but one only, who was 39 years of age, clinically and biologically produced the menopausal syndrome. The reversibility of the procedure has not been tested. Ovariotexy is not without risks, but these seem to be lessened when the operation is carried out on ovaries that are anatomically and functionally normal.

Female↗
PubMed1973

Primer requirement and template specificity of a DNA polymerase of chick embryo.

A DNA polymerase purified from extracts of chick embryo catalyzes the synthesis of poly(dT) in the presence of poly(rA) or poly(dA) as template and poly(dT) or oligo(dT) as primer. Oligo- or polyribonucleotides are relatively ineffective initiators of polydeoxynucleotide polymerization. Using activated DNA as template, the enzyme catalyzes a repair-like reaction that resembles that catalyzed by RNA-directed DNA polymerase of RNA tumor viruses and Escherichia coli DNA polymerase II. With natural templates containing poly(rA) sequences, such as avian myeloblastosis virus RNA or rabbit globin mRNA, and oligo(dT) as initiator, principally poly(dT) is synthesized. Consequently, the enzyme differs from the RNA-directed DNA polymerase associated with RNA tumor viruses by its incapacity to transcribe heteropolymeric regions of RNA templates. The possible role of the enzyme in repair of DNA during transcription is discussed.

Adenine Nucleotides↗