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Biomedical subjects

G Broggi

Publications and source records attributed to G Broggi.

At least 127 records · Page 7Linked to original sources

Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit.

The sciatic nerve was exposed to cryoinjury at different freezing patterns in albino rats and rabbits and the frozen nerves were serially examined with electron microscopy from the time of cryolitic lesion (--60 degrees C for 3 minutes) for up to 28 days. The cryolesion was characterized by a total degeneration of the myelin fibers, while non-myelin fibers and vessels seemed less affected. Regeneration began 8 days after cryolysis. A peculiar pattern was the absence of Schwann cells, while the basal membrane around regenerating axons remained intact. The hypothesis that the basal membrane might play a role is discussed.

Animals↗

[Methodology and prognostic reliability of stereotaxic biopsy in tumors of glial origin].

Between 1978 and 1984, 227 patients affected from glial tumors underwent serial stereotactic biopsy. Correct prognostic indications have been obtained in 85% of the entire series. In 10.5%, the stereotactic procedure provided only the diagnosis of the nature of the tumor, while the histological grading and prognosis remained unknown. The operative mortality was 2.6% and the permanent morbidity included 3.9% of patients who complained about worsening of the preoperative neurological conditions. The methodology of stereotactic biopsy is described in detail. The results are discussed with particular reference to the prognostic value of serial stereotactic biopsies.

Adolescent↗

Three-dimensional reconstruction of neuroradiological data within a stereotactic frame of reference for surgery of visible targets.

Three-dimensional information obtained with neuroradiological exams performed under stereotactic conditions is displayed on a surgical console within the graphic reconstruction of the geometry of stereotactic frames. Planning of convenient probe trajectories can be carried out taking into account all data derived from different diagnostic techniques.

Computer Graphics↗

Magnetic resonance imaging in intracranial gliomas. Comparison with computed tomography and serial stereotactic biopsy.

Findings at magnetic resonance imaging (MRI) and computed tomography (CT) where reviewed in 53 surgically confirmed cases with glioma. Astrocytomas showed a constant MR signal pattern in 87 per cent and glioblastomas in 80 per cent. This pattern was found useful when it was correlated with CT. MRI was also found to be of value in planning stereotactic biopsy and in confirming the trajectory.

Biopsy↗

[Magnetic resonance in the study of cerebral gliomas].

Forty surgically proved gliomas have been studied by MR: 21 were low-grade gliomas and 19 were anaplastic astrocytomas and glioblastomas. The examination involved the use of T1-weighted (IR and/or SE, TR 500 ms, TE 50 ms) and T2-weighted scans (SE, TR 1000 ms, TE 50 with multiple echos). All patients underwent CT and surgical removal or stereotactic biopsy whose findings were retrospectively compared with those of MR. MR findings were similar in low-grade and anaplastic astrocytomas, but quite different from imaging of glioblastomas. Tumoral cyst and areas of necrosis were recognized on MR studies and confirmed by surgical findings. Differentiation between tumor and oedema was difficult. The MR images did not allow a more specific diagnosis of nature or of malignancy than available with CT up to now, but offer major advantages, such as a superior depiction of tumor extent and anatomic relationships.

Adolescent↗

Cell kinetics of gliomas by serial stereotactic biopsy.

The potential proliferative activity of glial tumors has been investigate by serial stereotactic biopsies and by "in vitro" 3H-thymidine incorporation procedure (labeling index, LI). The methodology of this combined approach and the preliminary results in 33 patients are reported. Cell kinetic data have been matched with the histological classification (W.H.O.).

Adolescent↗

Treatment of deep brain abscesses by stereotactic implantation of an intracavitary device for evacuation and local application of antibiotics.

Complete recovery from deep brain abscesses was achieved in four patients treated by a specialized stereotactic method. In one patient the lesion was in the right thalamus, in two patients within the brain stem and in one case in the right rolandic cortex. The technique consists in the stereotactic implantation of a chronic intracavitary catheter connected to a subcutaneous reservoir to allow postoperative multiple evacuations and local antibiotic irrigations. Serial CT scan examinations guided the timing of intracavitary treatment and the removal of the catheter. No recurrence developed. The diagnostic and therapeutic advantages of this stereotactic technique are emphasized.

Anti-Bacterial Agents↗

Digital image processing to handle neuroanatomical information and neurophysiological data.

An application of computer graphics technology to functional stereotactic neurosurgery is presented. Neuroanatomical images derived from a stereotactic atlas and information retrieved from a neurophysiological data base are drawn on a graphic monitor. The pictures are oriented and scaled according to appropriate landmarks. The aim of this work is to add confidence in the surgeon's selection of the probe trajectory and to improve the knowledge of sensory and motor organization within the thalamus.

Brain↗

Cell kinetics of neuroepithelial tumors in serial stereotactic biopsies. A new combined approach.

33 consecutive patients with brain glial tumors underwent serial stereotactic biopsies and (3H)-thymidine in vitro investigation. The labeling index has been determined in each case and matched with the WHO histological classification. The feasibility and the accuracy of cell kinetics study applied to stereotactic biopsies are discussed in view of future application for prognostic purposes. Particular attention is given to the description of the method.

Adolescent↗

[Functional neurosurgery of cerebral palsy].

In 1983, approximately 40 000 patients in France and 5 760 patients in Switzerland suffered from cerebral palsy, representing more than 0.1% of their respective populations. The functional disability of these patients is particularly impressive and emphasizes the medical, social and economic importance of this problem. The term cerebral palsy is restricted to non-progressive disorders of motor function, already observed at an early age and due to cerebral lesions. These motor disorders can be of paretic, dystonic and dyskinetic nature. Their epidemiology, classification, etiology, pathology, early diagnosis and evolution are extensively reviewed by Th. Deonna. The difficulty in evaluation of treatment is the absence of a generally accepted rating scale. G. Broggi has proposed one on the basis of a large experience which could serve in the future for more objective evaluation. This monograph is devoted to the functional neurosurgical treatment of cerebral palsy. Physiotherapy and rehabilitation are part of the basic treatment of cerebral palsy, and must be continued after any neurosurgical treatment. Various conservative methods of treatment and their neurophysiological rationale are mentioned by P. Claverie. Some technical devices which improve the neurological deficits and facilitate rehabilitation are presented. Radiculotomies and neurotomies are probably the oldest neurosurgical operations for the treatment of spasticity. The neurophysiological and neuroanatomical basis of this therapeutic approach are treated in the review of the material from the neurosurgical department of Montpellier. Sixty cases were collected and the results analysed according to the type of operation (posterior radiculotomy, anterior radiculotomy, mixed) performed. Stereotactic thalamotomies and subthalamotomies are believed to be the best neurosurgical method to treat the tremor and improve other dyskinesias and hyperkinesias. The technique and a personal review of 49 cases of cerebral palsy are presented. The long-term follow-up in this study demonstrates that this type of operation markedly improves the functional disability of patients with moderate hyperkinesias, moderately improves patients severely affected, but also demonstrates that possible side effects cannot be ignored. Review of the literature indicates the difficulty in interpretation of results due to a lack of objective evaluation. Nevertheless, stereotactic thalamotomy can still be recommended when tremor and rigidity are the most prominent symptoms. Stereotactic dentatotomies in the treatment of spasticity were very popular 20 years ago, but have been largely forgotten for nearly a decade.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

Surgical treatment of glossopharyngeal neuralgia and pain from cancer of the nasopharynx. A 20-year experience.

The outcome is summarized for 14 cases operated on for glossopharyngeal neuralgia, with both open and percutaneous rhizotomy techniques, between 1960 and 1984. Four patients, all with primary neuralgia, underwent open surgery. Pain disappeared, leaving only a ninth nerve deficit in all but one patient; in that patient, paroxysms of pain recurred after 3 years, mediated by the nervus intermedius. Five other patients with idiopathic neuralgia and five patients with pain secondary to carcinoma underwent percutaneous procedures. Seven patients who had retrogasserian percutaneous rhizotomy for associated trigeminal neuralgia were also pain-free. No mortality or morbidity resulted from either type of procedure.

Adult↗

Neuroanatomical digital image processing in CT-guided stereotactic operations.

In order to utilize computed tomography (CT) for functional neurosurgical procedures, a number of problems must be resolved. One such problem is the development of an appropriate technique for digital processing of neuroanatomical images. Our previous work concerned a numerical reproduction of a well-known stereotactic atlas and its three-dimensional manipulation. In order to efficiently utilize this information with CT images we propose a technique for data reduction that allows the reconstruction of anatomical structures from the atlas. The logic of implementing these data in CT-assisted stereotactic surgery is described.

Brain↗