Genetic model for observed distributions of proportions of haemoglobin in sickle-cell trait.
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Anemia, Sickle Cell↗
Biomedical subjects
G Brittenham
Publications and source records attributed to G Brittenham.
Sickle cell anemia and trait in a population of southern India.
In an ethnic group in southern India, the Irula, seven individuals with sickle cell anemia were found to manifest only mild illness. Although a relatively high level of fetal hemoglobin was present in one, none of the factors thought to ameliorate the course of sickling disorders could be identified in the remaining six. In a random population survey, sickle hemoglobin was found in 90 of 292 Irula (31%). In those with sickle cell trait, the proportion of sickle hemoglobin in hemolysates (mean = 26%, range 19-32%) was substantially lower than that reported for any other population.
Anemia, Sickle Cell↗