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Biomedical subjects

G Breitling

Publications and source records attributed to G Breitling.

6 recordsLinked to original sources
PubMed1982

[Bone marrow transplantation in patients with leukemia].

Between October 1979 and March 1982, bone marrow transplantations were performed by the Tübingen Group for BMT on 19 patients with acute leukemia in remission and on one patient with chronic myelocytic leukemia in chronic phase. The conditioning regimen consisted of 2 x 60 mg cyclophosphamide/kg and 10 Gy whole-body irradiation with the linear accelerator. The lung dose was limited by shielding to 8 Gy. In 15 patients, the bone marrow cell suspension of the donor was preincubated with antihuman T-cell globulin (AHTCG) for prophylaxis of graft-versus-host disease (GVHD). All patients showed prompt engraftment of donor cells with good hemopoietic function and complete chimerism. Under reverse isolation in sterile units, no severe bacterial or fungal infections were seen in the phase of bone marrow aplasia. Twelve in twenty patients survived between 25 and 900 days. A severe GVHD was seen only in two patients - one after preincubation with AHTCG. One patient died from relapse of his leukemia, another patient had a testicular relapse which was treated with local radiotherapy. Major problems were seen with chronic GVHD (six patients) and infectious complications, most importantly interstitial pneumonia, in the late post-transplant period.

Acute Disease↗
PubMed1978

[The use of computer tomography in individual treatment planning (author's transl)].

Computer tomography provides the possibility of individual treatment planning. For this purpose it is necessary to obtain the matrix of linear absorption coefficient for the type of radiation used during radiotherapy. In this paper it is shown that it is necessary to obtain a cross section of the patient using rays of two different qualities. From these results and previous measurements on phantoms it is possible to calculate the density and effective atomic number. It is also shown that the most significant information is obtained from the density matrix, if ultra hard X-rays are used for radiation therapy; With this density matrix it is possible in a simple manner to take account of inhomogeneities within individual patients.

Absorptiometry, Photon↗