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Biomedical subjects

G Breart

Publications and source records attributed to G Breart.

At least 37 records · Page 2Linked to original sources
PubMed1994

Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics.

A double-blind, randomised, parallel group study has been done comparing the efficacy and tolerability of 7.5 mg/kg ibuprofen syrup (n = 77) and 10 mg.kg-1 acetaminophen syrup (n = 77) in 154 children (6 months to 5 years) with fever (> or = 38 degrees C) associated with infectious diseases and treated with antibiotic therapy. The area under the percentage reduction in temperature curve captured the net effect of each drug and provided the best estimate for comparison of efficacy during a defined period. Temperature evolution over time was not significantly different between the two groups. Nevertheless, the temperature reduction over the first 4 h of treatment (H0-H4) was significantly higher after ibuprofen (60%) than acetaminophen (45%). Both ibuprofen and acetaminophen were well tolerated. In conclusion, significant antipyretic activity, good tolerability and its availability as a syrup make ibuprofen an effective means of fever control in children.

Acetaminophen↗
PubMed1993

Epidemiology and risk factors of osteoporosis.

Recent osteoporosis research has been oriented increasingly toward understanding the determinants of peak bone mass acquisition during childhood and adolescence. Genetic factors may account for approximately half of the variability in peak femoral bone mass density, and racial differences in bone mass have been shown to appear early in life. Physical activity appears to play an important role in increasing bone mass during childhood. Most fractures in the elderly have been found to be associated with reduced bone mass and could therefore be considered osteoporotic. Retrospective reviews of medical records from residents of Rochester, Minnesota, suggest that approximately one third of women with vertebral deformities seek medical attention. Other cross-sectional data suggest that vertebral deformities cause substantial back pain and disability only if vertebral height ratios fall 4 SD below the mean.

Aging↗
PubMed1992

Determinants of hormonal replacement therapy in recently postmenopausal women.

Although the efficacy of hormonal replacement therapy (HRT) on the consequences of the menopause is not questioned, it appears that in Europe and in the USA only a small proportion of women are users of HRT. In this study, we examined the prevalence and the determinants of HRT among 1986 French menopausal women, aged 45 to 55 years, presenting to a preventive medicine centre. Overall, 8.1% of women reported current use of HRT. The estrogen preparation most commonly reported was transcutaneous 17 beta-oestradiol. The first determinant of current HRT was birth-place. Women born in France were nearly four times more likely to be on treatment than foreign-born women. A surgical menopause multiplied the probability of current HRT by 2, as did a high level of education. An age at first pregnancy of more than 20 and less than 4 children were also positively linked with HRT use. Even in this population of recently menopausal women, volunteering to undergo health evaluation, the prevalence of HRT was low. The reservations towards HRT may be partly due to the women themselves, and partly due to the physicians. It seems very important to inform the medical profession about the risks and benefits of HRT, and to understand more precisely the reasons why so few women use HRT.

Administration, Cutaneous↗
PubMed1992

Home visits for pregnancy complications and management of antenatal care: an overview of three randomized controlled trials.

OBJECTIVE: To examine whether a policy of home visits reduces the amount of antenatal care provided by hospital maternity units. DESIGN: A meta-analysis of three randomized controlled trials. SETTING: 9 maternity units in France. SUBJECTS: 1410 women with pregnancy complications. INTERVENTION: 1 or 2 home visits a week by a midwife. MAIN OUTCOME MEASURES: Admission rate and length of stay in hospital. RESULTS: The home-visiting system did not affect the hospital admission rate (typical odds ratio = 0.9; 95% CI = 0.7-1.2). In each trial, the length of hospital stay did not differ between the intervention and the control groups. CONCLUSIONS: The home-visiting system did not greatly alter the practice of antenatal hospital admission in the maternity units studied. The results question the way the health services were used and suggest that a better integration of hospital and home services is needed to make a more rational use of health care resources.

Female↗
PubMed1992

Effect of chloroquine chemoprophylaxis during pregnancy on birth weight: results of a randomized trial.

To determine the effect of chloroquine chemoprophylaxis during pregnancy on birth weights, a randomized trial was carried out in 1987 and 1988 in Banfora, Burkina Faso (West Africa). Seven hundred forty-five randomly selected women treated with chloroquine sulfate were compared to with 719 controls who received no treatment. In spite of an unquestionable effect of chloroquine in preventing placental infection (4.1% infected placentas in the treated group versus 19.0% in the controls), the mean difference in birth weights between the two groups (6 g) was not significant. The difference in the proportion of low birth weight (LBW) newborn babies in two groups (16.3% versus 16.4%) was also not significant. However, there was a strong relationship between placental infection and birth weight (the mean birth weight difference between infected and uninfected placentas was 113 g, and the proportion of LBW babies was 26.0% in infected placentas versus 14.8% in uninfected placentas). The small difference in birth weights observed between the two groups may be due to the fact that the prevalence rate of placental infection is low and that prophylaxis is effective only on a portion of the subjects in the treated group. It may also indicate that malaria is only one of several risk factors responsible for LBW. The relatively small increase in birth weight, the expected poor acceptance of mass prophylaxis, and the spreading of chloroquine-resistant Plasmodium strains should be considered before extending malaria chemoprophylaxis to all pregnant women. It might be worth considering to limit prophylaxis to primigravidae.

Adult↗
PubMed1991

[Epidemiological study of 200 HIV infected pregnant women].

Demographic characteristics and lifestyle were studied among 200 HIV-seropositive women followed in a tertiary care obstetrics/gynecology center in Paris. Between 1985 and 1989, a detailed questionnaire was run by a specialized midwife. The study group, mostly comprised of pregnant women, was compared with the women delivering in the department and with the overall French pregnant population. The women's partners were also studied. There appeared to be a core group of women who are young, single, often unemployed, marginalized members of foreign-born minorities, heavy smokers, and past or present intravenous drug users. Among their partners, drug use was frequent; over half were born in sub-Saharan Africa or North Africa and one third were unemployed. Among women having a job, white collar employees and service workers were over represented, whereas blue collar workers were under represented. The epidemiological profile of HIV-infected women appears to be very different from that of the largely homosexual male population in France. These women are younger and often less intellectual, poorer, more socially marginalized and less receptive to campaigns for prevention. However, the majority of our patients are married or live maritally, work and do not (presently) use drugs.

Adult↗
PubMed1991

Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial.

The efficacy of low-dose aspirin in preventing fetal growth retardation was tested in a randomised, placebo-controlled, double-blind trial. A secondary aim was to find out whether dipyridamole improves the efficacy of aspirin. 323 women at 15-18 weeks' amenorrhoea were selected at twenty-five participating centres on the basis of fetal growth retardation and/or fetal death or abruptio placentae in at least one previous pregnancy. They were randomly allocated to groups receiving placebo, 150 mg/day aspirin, or 150 mg/day aspirin plus 225 mg/day dipyridamole, for the remainder of the pregnancy. In the first phase of the trial all actively treated patients (n = 156) were compared with the placebo group (n = 73). Mean birthweight was significantly higher in the treated than in the placebo group (2751 [SD 670] vs 2526 [848] g; difference 225 g [95% CI 129-321 g], p = 0.029) and the frequency of fetal growth retardation in the placebo group was twice that in the treated group (19 [26%] vs 20 [13%]; p less than 0.02). The frequencies of stillbirth (4 [5%] vs 2 [1%]) and abruptio placentae (6 [8%] vs 7 [5%]) were also higher in the placebo than in the treated group. The benefits of aspirin treatment were greater in patients with two or more previous poor outcomes than in those with only one. In the second analysis, of aspirin only (n = 127) vs aspirin plus dipyridamole (n = 119), no significant differences were found. There was no excess of maternal or neonatal side-effects in the aspirin-treated patients.

Adult↗
PubMed1991

[Working conditions of women with arterial hypertension during pregnancy].

The relationship between working conditions and arterial hypertension (blood pressure greater than or equal to 140.90 Hg) during pregnancy has been studied from a representative sample of births in France in 1981. The study sample consisted of 2,587 women who had worked beyond the first trimester of pregnancy. The rate of arterial hypertension was 11%: it was higher for women who had to carry heavy loads or who worked in noisy environment, even if known risk factors of hypertension were taken into account. This relationship is obvious for women who were exposed for a long time--working hours or length of employment. Noise and carrying heavy loads seem related to arterial hypertension at different stages of the pregnancy, as if the physiological processes related to these two working conditions were different.

Adult↗
PubMed1990

A randomized comparison of early with conservative use of antihypertensive drugs in the management of pregnancy-induced hypertension.

Two treatment strategies were compared in 155 women with pregnancy-induced hypertension who were also given comprehensive non-pharmacological care. The mean gestation at entry was 28 weeks. As long as the diastolic blood pressure (DBP) remained below 106 mmHg, oxprenolol, or oxprenolol plus dihydralazine, were given to the early treatment group, and matching placebos to the control group. Open antihypertensive treatment was provided for patients whose DBP rose above 105 mmHg. Proteinuria occurred in seven women in each group. In the early treatment group, 13 of the 78 women were delivered by caesarean section; the corresponding numbers in the control group were 27 of 76 (17 vs 36%, 95% confidence interval (CI) of difference: 5-33%); the sections included seven and 16 in the early treatment and control groups, respectively, for severe hypertension and/or fetal distress. There were five perinatal deaths, two in the early treatment group and three in the control group. Early treatment did not influence gestational age at birth or birthweight. Respiratory distress syndrome occurred in four infants in the early treated group and in 10 in the control group; 14 infants in the former group and 26 in the latter were in hospital for more than 10 days (18 vs 35%; 95% CI of difference 4-32%). These results indicate that early antihypertensive treatment with oxprenolol is safe for the fetus and newborn in pregnancy-induced hypertension, but has no advantage over non-pharmacological care in terms of fetal growth. However, it may prevent acute hypertension in late pregnancy and associated fetal distress, and thus reduce the number of caesarean sections.

Adult↗
PubMed1989

Ultrasound in obstetrics: do the published evaluative studies justify its routine use?

A review of surveys assessing the use of ultrasound in obstetrics was undertaken to determine why this examination has spread so rapidly. Seven randomized controlled trials (RCTs) published to date as well as 182 papers published in four obstetric journals between 1979 and 1984 were reviewed. The value of routine ultrasound scanning to improve the diagnosis of intrauterine growth retardation or gestational age was demonstrated in the RCTs, but the results of the RCTs measuring the effects on health of this screening procedure did not give strong evidence for its routine use. Of the 182 papers identified, 137 were related to the diagnostic assessment of ultrasound, 14 concerned the effects on medical practice and only nine papers studied the effects of ultrasound scanning on health. Most of these 137 papers came out in favour of this procedure. Thus the spread of ultrasound scanning was based mainly on evaluative surveys which assessed its diagnostic value.

Evaluation Studies as Topic↗