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Biomedical subjects

G Brasseur

Publications and source records attributed to G Brasseur.

At least 109 records · Page 6Linked to original sources
PubMed1984

[Ocular toxocariasis. Diagnostic and therapeutic attainments].

Toxocara canis is nematode parasite of dogs. Children are particularly subject to infestation, however the larva remains quiescent at stage II. Toxocara can localize in the eye and induce a variety of clinical manifestations. A case of ocular toxocara is presented in which there was granulomatous endophthalmitis. Immunologic testing was negative in the serum but positive in the vitreous, where numerous eosinophils and plasma cells where found. Vitreous and aqueous IgE levels were elevated. Corticosteroid therapy was ineffective in quieting the inflammation, but vitrectomy was beneficial. Biological testing demonstrated the advantages of using specific antigens with ELISA techniques. Negative test results in the serum do not obviate the need to perform assays of the aqueous and/or vitreous. The demonstration of an eosinophilic inflammatory response and elevated IgE levels support the diagnosis of ocular parasite infection. In the absence of specific anti-parasite therapy corticosteroid treatment appears to yield inconsistent results. Vitrectomy seems to be beneficial in these circumstances. The new diagnostic technique should improve the accuracy of ocular toxocara diagnoses.

Aqueous Humor↗
PubMed1982

[Cerebrotendinous xanthomatosis: long-term treatment with chenodesoxycholic acid (author's transl)].

A case of cerebrotendinous xanthomatosis without hyperlipidaemia but with tendinous scanthomatosis, subtle neurological disorders and endocrine cataract is reported. Accumulation of cholestanol, a cholesterol derivative, was detected by mass fragmentography. The plasma cholestanol : cholesterol ratio was 30 times higher than normally. Treatment with chenodesoxycholic acid during 26 months brought about neurological improvement, stabilization of the cataract and xanthomatosis and return to normal of plasma cholestanol levels.

Adult↗
PubMed1982

[Anatomo-clinical and therapeutic aspects of Candida albicans endophthalmitis].

Endophthalmia due to Candida has increased in incidence over the last few years, particularly in drug addicts. Two cases of severe bilateral Candida albicans endophthalmia are reported. Histological examination of the globes following treatment by amphotericin B i.v. and secondary vitrectomy demonstrated persistence of Candida, particularly in the preretinal membrane, in the first case. Treatment in the second case consisted of amphotericin B i.v. and 5 fluorocytosine, associated with vitrectomy and an intravitreal injection of 5 micrograms of amphotericin B. Fungal elements were absent on histological examination of the globes. Ocular Candida albicans lesions may be of exogenous origin but contamination arises more frequently from an endogenous source. The resulting endophthalmia leads to retinal nodules having a tendency to extend into the vitreous. Clinical features are fairly typical and diagnosis not a problem. General treatment consists of combined administration of amphotericin B and 5 fluorocytosine, but results are often disappointing as effective penetration of these compounds into the intraocular zone is not obtained. Early vitrectomy, when a vitreal lesion exists, offers many advantages such as the possibility to identify Candida in the removed aqueous humor. As histological examination shows persistence of Candida in the preretinal membrane, the vitrectomy should be combined with intravitreal injections of amphotericin B.

Aged↗