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Biomedical subjects

G Brandi

Publications and source records attributed to G Brandi.

139 records · Page 8Linked to original sources

[Hymenoptera sting arthropathy as an occupational injury: a case report].

Hymenoptera (Apid and Vespid) sting reactions represent a specific occupational risk factor for beekeepers, farmers, floriculturists, forestry workers, gardeners, greenhouse workers, fruit dealers, fire-fighters, street sweepers, outdoor workers. As a consequence of the Hymenoptera stings it can appear: acute toxic or allergic reactions and sub-acute symptoms that involve various body systems including the joints in which a Hymenoptera Sting Arthropathy (HSA) may occur. We describe the case of a 54-year-old male farmer beekeeper who developed in 1998 a systemic reaction due to multiple bee stings while he was collecting honey. He was hospitalised at the Policlinico Gemelli in Rome because skin (prick and intradermal test) and in vitro tests had shown evidence of an allergic reaction and had required a venom immunotherapy. During the years the patient had been victim of various episodes of acute arthritis on his interphalangeal joints) and, in one occasion, on his right elbow. The symptoms were localized intense pain and a severe impairment of joint function with inability to perform the work. After 7-14 days of corticosteroid treatment the arthritis subsided. In literature there are similar cases described that, at times, assume a greater severeness and lead to significant functional outcomes. The HSA's aetiology includes pharmacologically active substances (melittin, phosfolipase A2, leukotrienes present in venom), infection, or foreign body synovitis. The relative gravity of the symptoms and the possibility of outcomes all indicate that further attempts must be made in order to prevent HSA.

Acute Disease↗

[Disinfection efficiency of peracetic acid, alone and in combination with hypochlorite, against Mycobacterium avium in drinking water].

Peracetic acid (PAA) is a disinfectant with a wide spectrum of antimicrobial activity, but little is known about the feasibility of using it in the field of drinking water treatment. The aim of this study has been assess disinfectant efficacy of PAA, alone or in combination with hypochlorite, against M. avium in drinking water M. avium is a common opportunistic pathogen in immunocompromised subjects that is able to survive and grow in drinking water distribution systems. In this study PAA did not show appreciable activity against the greater number of tested strains (16/21) up to 5 ppm of PAA, a weak activity was seen on 4 strains, while a significant reduction in viable cells (about 50%) was seen only on 1 strain after 48 h of treatment with 5 ppm of PAA. We also evidenced that M. avium was unaffected by chlorine concentration usually present in drinking water distribution system. Finally, the combination of PAA and sodium hypochlorite did not promote enhanced antimicrobial efficacy respect to the single disinfectants. In conclusion, our result would indicate that PAA is an unlikely candidate for the disinfection of drinking water from M. avium and further strategies are required to eliminate M. avium from drinking water system.

Disinfectants↗

Cell renewal and cancer risk of the stomach: analysis of cell proliferation kinetics in atrophic gastritis.

We examined cell proliferation kinetics of gastric mucosa in 28 patients affected by chronic atrophic gastritis by means of autohistoradiography of biopsies incubated with tritiated thymidine. The results have been compared with those obtained from 12 patients with normal gastric mucosa. In chronic atrophic gastritis, patients showed a proliferative pattern similar to controls. The remaining patients had an increased number of replicating cells together with an expansion of the proliferative compartment towards the surface of the mucosa. These results suggest that in chronic atrophic gastritis, as far as cell proliferation is concerned, two subgroups of patients with two different levels of risk of developing gastric cancer exist. The first one, showing an expansion of the proliferating area, probably is at higher risk. As a matter of fact, such an abnormality expresses an alteration of cell growth control similar to that observed in preneoplastic conditions of the colon and in gastric mucosa of animals treated with carcinogenic substances.

Adult↗