Biomedical subjects

G Brandesky

Publications and source records attributed to G Brandesky.

At least 37 records · Page 2Linked to original sources

PubMed1976

Operations for the improvement of faecal incontinence.

Experiences and results are reported of Pickrell's gracilis sling transplantation in 30 cases. 24 cases could be followed up. In 21 of these there was definite improvement of continence. The favourable results are attributed to the contractibility of the muscle after transplantation. After high anal and rectal atresiae, a maturation of anorectal structures and a belated rectal adaption reaction may be observed, which can be attributed to the gracilis sling operation. It seems, therefore to be sensible to perform the operation earlier than has been practised hitherto.

Age Factors↗

PubMed1975

[Pharmacokinetic and chemical investigations in children after oral administration of lidaprim (author's transl)].

Lidaprim, a new bactericidal combination of trimethoprim and sulfametrol, was administered to 20 patients of a paediatric surgical ward over a period of 7 or more days. Analytic determination of plasma and urine concentrations of the chemotherapeutic agent showed homogeneous drug levels at the chosen dosage. No cumulation was observed. Drug tolerance was excellent. Only one patient developed urticaria when the substance was given together with penicillin, but it was not necessary to stop medication in this case.

Child↗

PubMed1975

[The Surgical Management of Faecal Incontinence in Childhood (author's transl)].

A series of 13 cases is reported in which gracilis muscle transplantation according to Pickrell was carried out. In half of the cases a modification using bilateral gracilis muscle transplants was performed. 10 children were followed up; 8 of them showed an improvement in faecal continence. Preserved contractility of the transplanted gracilis muscle seemed to be responsible for this improvement. Since maturation of anorectal structures after surgical correction of high anorectal atresias and late development of anorectal mechanisms seems possible and might to be assisted by transplantation, early surgery -- about the fourth year of life -- is recommended.

Age Factors↗

PubMed1975