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Biomedical subjects

G Brüggemann

Publications and source records attributed to G Brüggemann.

7 recordsLinked to original sources

Influence of different approaches for calculating the athlete's mechanical energy on energetic parameters in the pole vault.

The purposes of this study were as follows: (1) To determine the differences between two- and three-dimensionally calculated energy of the athlete in the pole vault. (2) To determine the differences between CM energy and total body energy. (3) To examine the influence of these different approaches of calculating the athlete's energy on energetic parameter values during the pole vault. Kinematic data were gathered during the pole vault final of the track and field world championships in 1997. Two video cameras (50Hz) covered the last step of the approach including the pole plant and 2 cameras covered the pole phase up to bar clearance, respectively. Twenty successful jumps were analysed. The characteristics of the energy development is similar for the different approaches. Initial energy, energy at maximum pole bend and energy at pole release (primary parameters) show significant differences (p<0.05). The findings indicate that rotatory movements and movements relative to the CM have a larger influence on the primary parameters than movements apart from the main plane of movement. For analysing the energy exchange between the athlete and the elastic implement pole only the differences among the secondary parameters (initial energy minus energy at maximum pole bend, final energy minus energy at maximum pole bend) are needed (Arampatzis et al., 1997 Biomechanical Research Project at the Vth World Championships in Athletics, Athens 1997: Preliminary Report. New Studies in Athletics 13, 66-69). For those parameters the relative differences between the calculation approaches range only between 1.47 and 0.04%. This indicates that the influence of the different approaches for calculating the athlete's energy on the analysis of energy exchange is negligible.

Biomechanical Phenomena↗

Adaptation of the human calcaneus to variations of impact forces during running.

OBJECTIVE: The influence of varied forces under the heel induced by changes in midsole hardness on adaptations of the human calcaneus during running training was investigated. DESIGN: A longitudinal study was conducted over a period of 20 weeks with subjects training for 50 km per week on average. BACKGROUND: The skeletal systems' metabolism acts highly dynamic, governed by mechanical factors. The amount of running training has been shown to increase the bone mineral density in the calcaneus. Mechanical factors have not been controlled in former investigations. METHODS: Bone quality parameters were determined before and after the training by use of an ultrasound system and quantitative MRI while the mechanics of foot-ground contact were controlled. The total group of 26 subjects was divided into three subgroups based upon different magnitude of forces under the heel inside the shoe. RESULTS: The biomechanical testing demonstrate no relationship between midsole hardness and external or in-shoe impacts. Bone parameters showed specific differences for all groups which are pronounced in runners with intermediate impacts. CONCLUSIONS: The observed variations reflect metabolic changes in bone marrow which appear to be effected by the impact magnitude and cannot be characterised as negative. RELEVANCE: The current data imply that no negative changes of impacts on calcaneal bone were produced by high amounts of training in distance running. The mechanical testing indicates that the potential of modifying calcaneal adaptation directly by varying midsole hardness is limited.

Adaptation, Physiological↗

Diadenosine phosphates and the physiological control of blood pressure.

Our understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides, endothelial-derived relaxing factor and endothelin. Unidentified vasopressive agents have been found in platelets. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.

5'-Nucleotidase↗

[Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study].

Several clinical trials have shown that the duration of treatment of painful vertebral syndromes can be shortened by using a combination of vitamins B1, B6, B12 and diclofenac instead of diclofenac. In addition, a more efficient pain relief could be achieved by the combination therapy. In order to confirm these results, we compared the clinical efficacy of diclofenac (25 mg) and a combination preparation with diclofenac (25 mg) plus vitamins B1 (thiamine nitrate 50 mg), B6 (pyridoxine hydrochloride 50 mg) and B12 (cyanocobalamin 0.25 mg) in a multicentric randomized double-blind study including 418 patients. All patients received 3 x 2 capsules daily for a maximum of 2 weeks. In case of total pain relief, therapy should be discontinued after one week. Data of 376 patients could be evaluated. 53 out of 184 patients receiving the combination and 48 out of 192 patients treated with diclofenac alone could stop therapy due to sufficient pain relief after one week. The evaluation of the "Hoppe Pain Questionnaire" and the data concerning pain intensity also revealed better results for the combination preparation. The differences in favour of the B-vitamin-diclofenac-combination were statistically significant in patients with severe pain at the beginning of therapy. Considering undesirable side-effects (symptoms in 70 out of 418 patients) there were no significant differences between the two medications. This clinical trial provides further evidence that the combination therapy with diclofenac plus B-vitamins is more effective than diclofenac alone for the treatment of painful vertebral syndromes.

Adult↗

[Deep Q waves in the ECG of children--an electro-, vector- and echocardiographic study].

Out of 9557 children we found 120 children (1,26%), who showed deep Q-waves of greater than or equal to 0.4 mV in 3 consecutive ECG's at least in one of the leads I, aVL, V4, V5 and V6. 70 children were investigated additionally by echocardiography, 45 by vectorcardiography according to Frank. Echocardiography revealed an increased septal thickness in 5 patients, a borderline thickness in 8, an increased septal/posterior wall ratio in 4. In the vectorcardiogram 51,1% of the patients had no Q-waves in lead y, mostly in combination with deep Q-waves in a VL or left axis deviation. Q-waves in lead y were combined with Q-waves in V 5/6. The determination of the main axis coincided in 80% of ECG and VCG. Looking for the various heart diseases, 30% of the children with Q-waves had a ventricular septal defect, 23,3% an endocardial cushion defect, 10,8% a patent ductus arteriosus, 3,3% a bradycardia, 2,5% a Bland-White-Garland syndrome and 1,6% a hypertrophic cardiomyopathy. 17,5% of the children had an innocent heart murmur, 5,8% no cardiac symptoms. Other diseases were found in 5%. The most frequent cause of Q-waves in children were volume-overload of the left ventricle (35%) and left axis deviation (33,3%), whereas myocardial infarction and septal hypertrophy (3,3 and 4,1%) were of minor importance. In healthy children (23,3%) we could not find any pathomechanism.

Arrhythmias, Cardiac↗

[Pacemaker therapy in children].

Between 1975 and June 1987 55 children underwent first permanent pacemaker (PM) implantation. The patients' age at time of implantation ranged between 1 month and 17 1/2 years (mean 5 5/12 years). In all cases - except a 17 years old girl who received a transvenous endocardial lead - only epicardial screw-in electrodes were used. Only VVI-PM have been implanted. In 84% the indication for implantation was post-surgical brady-arrhythmia, in 16% it was an inborn or acquired disturbance of the conducting system. With our patients we have a survey of 2603 months of PM implantation. During this period 14 children underwent totally 20 revisions, in 50% the electrode was the cause of failure. The interval between two revisions calculated as a quotient from months of PM implantation and number of revisions has increased significantly during the last years and amounts now to 130 months. The relative low incidence of revisions is in our opinion mostly related to the nearly exclusive use of epicardial leads.

Adolescent↗

[Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes].

The use of nonsteroidal anti-inflammatory drugs (NSAID) such as diclofenac for treatment of degenerative rheumatic disorders of the lumbar spine is of great significance in orthopedic practice. Clinical studies have shown that concomitant treatment with vitamins B1, B6, B12 and diclofenac provides more efficient pain relief than treatment using diclofenac alone. This study was undertaken in order to determine whether the duration of treatment with diclofenac for lower back pain can be shortened by adding B-vitamins to the therapeutic regimen. From September through December of 1986, 256 patients participated in a multicenter, controlled, randomized double-blind trial which compared the clinical efficacy of diclofenac (50 mg) with a combined therapy of diclofenac (50 mg) and vitamins B1, B6, and B12 (thiamine nitrate, pyridoxine hydrochloride, and cyanocobalamine, resp.; in dosages of 50 mg, 50 mg, and 0.25 mg, resp.). Patients were treated with 3 X 1 capsule daily for a maximum of two weeks, having the option to terminate participation in the trial after 1 week in the event of total pain relief. The data of 238 patients were able to be included in the evaluation. 29 patients opted to discontinue therapy due to remission on symptoms. Nineteen (65.6%) of these patients belonged to the combined therapy group, the other 10 (34.4%) having taken diclofenac alone; this difference is statistically significant (p less than 0.05). An important aspect in the evaluation of therapy was the patient response regarding the improvement of painful symptoms which, in addition to their subjective feedback, was reflected in the test results of the "Hoppe Pain Questionnaire (HPQ)." All parameters used as a measure of pain relief indicated superior results with the B-vitamin supplemented therapy when compared with results obtained with diclofenac alone. Moreover, after 3 days of therapy the "sensory" pain factor "sharpness" improved significantly. Undesirable side-effects were documented with 39 patients, 14 of them having discontinued therapy for this reason. No statistically significant difference could be determined within this group with regard to therapy. The study results document the positive influence of B-vitamins on painful symptoms and indicate that less NSAID is needed for pain relief when combined with B-vitamins.

Clinical Trials as Topic↗