Biomedical subjects
Publications and source records attributed to G Bozler.
Analytical solutions for any linear compartment model are obtained empirically by use of simple rules. Set up of differential equations and tedious integration procedures are thus avoided. The procedure is suited for automation by a calculator. Integrated equations are accessible then even more simply and rapidly.
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An equation is given to describe the plasma level curve of any linear compartment model following multiple dosing of various doses after various time intervals. The equation is especially suitable to be used with desk top computers equipped with a plotting device. A dosage regimen can be simulated using the parameters derived from single dose experiments. Experimental check-up of the predicted curves is necessary and illustrated by two examples. Systematic deviations from the prediction indicate changes in the biological system, e.g., in absorption, by enzyme induction, saturable processes, etc.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.