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Biomedical subjects

G Boysen

Publications and source records attributed to G Boysen.

At least 145 records · Page 8Linked to original sources
PubMed1985

Effect of incremental doses of aspirin on bleeding time, platelet aggregation and thromboxane production in patients with cerebrovascular disease.

Bleeding time, thromboxane production and inhibition of platelet aggregation were studied before and during administration of acetylsalicylic acid in doses of 50, 100, 325 an 1000 mg daily in eighteen patients with cerebrovascular disease. Inhibition of thromboxane production and platelet aggregation was almost complete at 50 mg acetylsalicylic acid daily, and median bleeding time had increased significantly from 5.5 to 6.5 min at this dose and reached a maximum of 7.5 min at 100 mg daily. Further increase of the dose resulted in a slight decrease in bleeding time. It appears that a strong effect on platelet function can be achieved by small doses of acetylsalicylic acid, and that higher doses might be less effective.

Adult↗
PubMed1983

Brain CT-scanning and neurological examination in small cell bronchogenic carcinoma.

A brain CT-scan and a neurological examination were performed on forty-nine consecutive patients with small cell bronchogenic carcinoma before the start of chemotherapy and every three months thereafter. Contrast-enhancement was used in 90% of the CT-scans. Ninety percent of the neurologic examinations were performed by the same neurologist. No prophylactic cranial irradiation was given, and cranial irradiation was withheld if a CT-scan indicated metastases, unless the patient was symptomatic. Thirty-five patients are evaluable including 34 with a brain autopsy. CNS-metastases were found in 18 patients. Two of them had not been examined within three months of autopsy and are excluded from the calculations of diagnostic accuracy. Of the remaining 16 patients 10 had a correct diagnosis of cerebral metastases made by CT-scan, while the neurologist made 11 correct diagnoses of CNS-metastases. Seventeen patients did not have CNS-metastases including one patient alive and free of disease. Fifteen and 11 were judged to be free of metastases by the CT-scan and the neurologist, respectively. Two patients with negative autopsies had positive CT-scans turning negative at subsequent examinations. Two had positive CT-scans which became negative and at autopsy CNS-metastases were located at different sites from those initially indicated by CT. The positive predictive value of CT-scan was 71%, while the negative predictive value was 71%. In conclusion, routine CT-scan and neurological examination are equally sensitive but have low yields when there is no clinical suspicion of CNS-metastases. The predictive value of CT-scanning could possibly be higher with the newer generations of equipment.

Aged↗
PubMed1982

Prevalence of stroke in a district of Copenhagen the copenhagen city heart study.

From the city center of Copenhagen, almost 20,000 people, 20 years of age and older, were randomly selected for examination after age and sex stratification. The participation rate was 72%. 231 persons responded affirmatively to a questionnaire concerning cerebrovascular disease. After neurological examination the diagnosis was confirmed in 115 cases. Adjusted on the basis of the age distribution of the Danish population (1976) the prevalence rate was calculated to be 651/100,000 for men and 385/100,000 for women. The frequency of myocardial infarction and hypertension was significantly higher in the stroke patients than in the study population. The risk factors: cigarette smoking, serum-cholesterol, and high-density-lipoprotein concentration, showed no significant differences between the patients and the study population. 44% of the patients had had their stroke more than 5 years before the prevalence date. In 41% of the patients, residual neurological signs could not be demonstrated, while 59% of the patients had neurological deficits of varying severity. 30% of the surviving patients were in gainful work or managed domestic activities as they had done before the stroke. Nearly 1/2 of the severely disabled patients were independent in self care. The age group above 80 years was under-represented in this study.

Adult↗
PubMed1982

Intellectual function in patients with transient ischaemic attacks (TIA) or minor stroke. Long-term improvement after carotid endarterectomy.

Psychological testing was performed in 25 patients (mean age 56 years) with transient ischaemic attacks and/or minor strokes and with angiographically verified internal carotid artery stenosis. The effects of carotid endarterectomy on intellectual functions were evaluated postoperatively at 2 weeks and 8 months respectively. Preoperatively the mean test values were below the normal level for all tests indicating a general intellectual impairment for the group as a whole. This may reflect multi-infarct dementia in statu nascendi. At the early postoperative test session some test results were statistically significantly worse than the preoperative. 8 months postoperatively the mean values for all tests had improved as compared with the preoperative values. This improvement reached a statistically significant level in 6 tests. When the side of operation was considered a pattern emerged: in the 12 patients with left-sided endarterectomies improvement was significant for tests mainly related to left-hemisphere function (Word Pairs Test, Story Recall, Trail Making B, Similarities) and in the 13 patients with right-sided endarterectomies significant improvement occurred in the functions mainly related to the right hemisphere (Visual Gestalts, Block Design, Digit Span backwards). This relationship between side of operation and improvement in lateralized functions cannot be explained by retest effects. It is concluded that TIA's and minor strokes per se may impair intellectual function, and that reversal of deterioration and even improved mental state may follow carotid endarterectomy.

Adult↗
PubMed1980

Carotid endarterectomy in patients with cerebral transient ischemic attacks.

Eighty-seven consecutive patients with cerebral transient ischemic attacks (TIA) subjected to 98 surgical operations for stenosis of the internal carotid artery were followed for a period of 3.5 years in average. In the immediate postoperative period one patient died and two other patients had a severe neurological deficit. These complications occurred in patients where medical risk factors were present preoperatively. During the follow-up period six patients had a stroke. This figure is about 1/3 og the estimated expected number in an untreated patient group of the same size. Three strokes occurred from the hemisphere ipsilateral to the operated internal carotid artery and three from the contralateral hemisphere. Although estimation of expected number of strokes is associated with many uncertainties the present results suggest that carotid endarterectomy in patients with TIA and carotid artery stenosis reduced the frequency of strokes.

Adult↗
PubMed1979

Familial amyloidosis with cranial neuropathy and corneal lattice dystrophy.

Five siblings of a Danish family with slowly progressive involvement of the trigeminal, facial, glossopharyngeal, accessory, and hypoglossal nerves beginning at the age of 55-65 years were examined. All had asymptomatic corneal lattice dystrophy. Clinical and electrophysiological investigations also showed evidence of slight neurogenic involvement of the limbs. Conduction velocity along sensory nerves was normal but amplitude of sensory potentials was severely reduced suggesting an axonal affection which was confirmed by sural nerve biopsy. The neuropathy was secondary to amyloidosis revealed by skin and sural nerve biopsies.

Aged↗
PubMed1975

Effects of microembolization on the skeletal muscle blood flow. A critique of the microvascular occlusion model of Duchenne dystrophy.

Muscle blood flow (MBF) during exercise was determined in both anterior tibial muscles of 12 rabbits by the local 133-Xe method before and after embolization of 20 to 80 mum dextran particles into the right femoral artery. With a relatively low dose of particles (dry weight: 8.7 mg), MBF was significantly decreased up to 4 days after each embolization, and mild histologic abnormalities were observed in the embolized muscles. A four-fold higher dose resulted in a marked and permanent decrease of the MBF, ischemic necrosis of the distal leg muscles and toe gangrene. In the light of these findings and the previously demonstrated normal MBF in Duchenne dystrophy, the validity of the assumption that Duchenne dystrophy is caused by small vessel occlusions is questioned.

Animals↗