Biomedical subjects
G Born
Publications and source records attributed to G Born.
Surgical treatment of axillary osmidrosis.
Explore the source record for details and available documents.
Autotransfusion and reduction mammaplasty.
Explore the source record for details and available documents.
The "L" reduction mammoplasty.
In the breast reduction technique presented, the nipple and areola are carried on a total breast tissue pedicle elevated from the pectoral fascia. Breast tissues are resected inferior to the areola and from the pectoral aspect of the breast. The residual breast tissues are left in continuity with the nipple. Final repair is done with a medial triangular and a lateral rectangular flap. The resulting scar is "L" shaped without a medial component. The technique is applicable for breast reductions, equalizations, and mastopexies. The operation is safe, leaves satisfactory inconspicuous scars, and carries a very low incidence of complications.
Herpesvirus saimiri transformed human T cell lines: a permissive system for human immunodeficiency viruses.
Human peripheral blood T lymphocytes are readily transformed to continuous growth by Herpesvirus saimiri subgroup C strains. The immortalized cells express the phenotype of mature activated T cells and bear either CD4 or CD8 surface markers. Here we report that Herpesvirus saimiri transformed CD4+ cell lines are highly susceptible to infection with human immunodeficiency viruses types 1 and 2. The prototype viruses HIV-1IIIB and HIV-2ROD replicated rapidly and caused cell death within 14 days. These cell lines did also support growth of a poorly replicating HIV-2 strain (HIV-2NEP) and of primary clinical isolates. Thus H. saimiri transformed T cells represent a new system for HIV propagation and isolation, especially for HIV-2 strains with restricted cell tropism. These cells should be considered as an alternative approach in cases where conventional attempts fail.
Molecular and biological characteristics of a novel HIV-2 isolate, HIV-2HOM.
In 1991 a new HIV-2 isolate (HIV-2HOM) was isolated first from a German individual most likely infected in West Africa in the beginning of the 1970s. The virus was isolated from both, the plasma and the peripheral blood lymphocytes of the patient by using OKT-3-stimulated cord blood lymphocytes. The recovered viruses could be further propagated on Jurkat cells and exhibited a broad cell tropism. Biochemical and antigenic properties of HIV-2HOM were examined by radioimmunoprecipitations. For a more detailed molecular characterization, a 1520 bp DNA fragment from the env gene and a 722 bp DNA fragment from the pol gene were amplified by polymerase chain reactions, cloned and sequenced. A comparison of both sequences to prototypic HIV-2 and SIV isolates revealed a close relationship to HIV-2ST. This strain originated from an asymptomatic Senegalese individual and is supposed to be of reduced pathogenicity. Taking into account genetic data, it may be assumed that HIV-2HOM and HIV-2ST are closely related strains with different growth characteristics and pathogenic features.
Neuropathy after bupivacaine (Marcaine) wrist and metacarpal nerve blocks.
A series of 49 wrist and metacarpal blocks were done with the use of 0.25% or 0.5% bupivacaine in 44 patients for surgical and therapeutic purposes. Seven patients developed hypesthesia in the blocked nerve distribution lasting from 1 week to 4 months. One patient had pain and a positive Tinel sign in a dorsal branch of a digital nerve lasting 2 1/2 months. Since no neuropathies were reported in large series of nerve blocks with bupivacaine in other anatomic areas, it is postulated that bupivacaine in anatomically confined areas can cause a transient neuropathy possibly caused by a large local dose of the drug.
[What nurses criticize. Nursing from the nurses' viewpoint].
Explore the source record for details and available documents.
[Evidence for reduced colour vision in carriers of congenital colour vision deficiencies (author's transl)].
The ability to recognize small spots of coloured light in parafoveal regions of the retina was investigated in women heterozygous for protanopia (2 subjects), deuteranopia (2 subjects), or deuteranomaly (1 subject) and in 3 normal subjects. The homozygous colour normals had excellent discrimination up to 8 degrees excentricity, whereas in heterozygous carriers of congenital colour vision deficiencies the ability to differentiate colours varied from point to point within the retina. The results may be explained by assuming the existence of alternating patches of trichromatic and dichromatic cell populations with the retina of the heterozygous carriers.
Coloured stimuli within the central visual field of carriers of dichtomatism.
Explore the source record for details and available documents.