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Biomedical subjects

G Borgia

Publications and source records attributed to G Borgia.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Clinical and diagnostic considerations on a case of pancreatic plasmacytoma].

An unusual case of obstructive jaundice due to metastatic pancreatic plasmacytoma is described. Initially post-transfusion hepatitis was suspected in the patient who suffered from multiple myeloma (IgA) and had received numerous transfusions for severe anemia. Clinical and laboratory findings indicated obstructive jaundice and the ecographic examination showed a dishomogeneous mass at the level of the pancreas. The investigators suggest that after this type of ecographic finding a percutaneous biopsy should be performed eliminating exploratory laparotomy, a high risk procedure in this type of patient, and eventually radiotherapy should be initiated since this type of tumor is radiosensitive.

Female↗
PubMed1984

[Unusual ultrastructural findings in a case of asymptomatic primary biliary cirrhosis].

The investigators report an ultrastructural study of a case of primary biliary cirrhosis histologically in stage II (Scheuer), a rare disease which has not been investigated extensively at the ultrastructural level. Biliary canaliculi are dilated and microvilli are scarce. Large granular formations are observed in the perisinusoidal cytoplasm. The plasma membrane between adjacent hepatocytes appears convoluted. The ultrastructural alterations of the biliary canaliculi which we observed have been described in the literature in cholestatic patients and ascribed to cholestasis. Our patients, however, has never suffered episodes of jaundice or itching and has no histological signs indicating cholestasis. We suggest that these are precocious alterations which precede the appearance of clinical and histological signs of cholestasis. It is necessary to study other cases in order to evaluate the significance of the large granular formations and the changes observed in the plasma membrane.

Adult↗
PubMed1982

[Ultrastructural changes in hepatocytes of mice treated with morphine].

In a study of the ultrastructure of hepatocytes in mice treated with morphine a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with morphine increased significantly when compared to mice of control group (P less than 0.05 for surface density of smooth endoplasmic reticulum and P less than 0.01 for volume density of smooth endoplasmic reticulum). These ultrastructural changes after administration of morphine and related opiates are not accompanied by an increase of drug metabolizing enzymes and the huge tolerance observed in mice can be a phenomenon of adaptation at the receptor site (4).

Animals↗
PubMed1982

[Ultrastructural changes in hepatocytes of mice treated with heroin].

In a study of the ultrastructure of a hepatocytes in mice treated with heroin a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum and mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with heroin increased significantly when compared to mice of the control group. An increase in volume density of SER is generally believed to be correlated to an increase in drug metabolizing enzymes localized in or on smooth endoplasmic reticulum membranes. We have demonstrated a statistically significant increase in SER in mice treated with heroin which is not accompanied by an increase in drug metabolizing enzymes (7). We feel that further investigation of these anomalous cases is necessary in order to clarify the role of the SER membranes and their function in the metabolism of drugs.

Animals↗
PubMed1980

[Greater concentration of anti-hepatitis B antibodies (anti-HBs) in specific hyperimmune human gamma globulins (non-anti-hepatitis B) as compared with normal human gamma globulins].

Twenty-seven lots of standard immunoglobulin from 5 different producers and 18 lots of specific immunoglobulin (non anti-Hepatitis B) were titrated by RIA test for anti-HBs content. The highest titre in lots of standard IG (1:40) was lower than the lowest titre of the lots of specific IG (non anti-Hepatitis B) (1:44). The difference between means (1:17 and 1:42) was statistically significant (p less then 0,01). The reasons for the difference are discussed.

Antibodies, Viral↗