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Biomedical subjects

G Bolognini

Publications and source records attributed to G Bolognini.

23 records · Page 2Linked to original sources
PubMed1975

[Lymphoproliferative diseases and paraproteinemias in Sjogren's syndrome].

Out of 8 cases of Sjörgren's syndrome observed by the authors between 1964 and 1974, 5 presented wit clinically as well as theoretically remarkable combinations of Sjögren's syndrome with lymphoproliferative disorders i.e. non-classifiable lymphoproliferative disease (case 1), Hodgkin's disease (case 2), reticulum cell sarcoma (case 3), and asymptomatic paraproteinemia of type IgM/K (cases 4 and 5). In case 1, manifestation of a lymphoproliferative disorder was preceded by autoimmune hemolytic anemia. In agreement with communications from several other authors, our observations confirmed the frequent occurrence of autoantibodies in patients with Sjörgren's syndrome. Forty-two more cases of lymphoproliferative disease in Sjögren's syndrome were found in the literature (Table 4). Pathologenetic problems arising from these nosological combinations are discussed.

Aged↗
PubMedDate not supplied

[Systemic adjuvant chemotherapy of bladder carcinoma with 5 fluorouracil and cyclophosphamide].

Patients with bladder cancer in pT2 and pT3 infiltrating stages have a 5 year survival rate less than 50% after primary surgical and/or radiant therapy. Aim of the present study was to evaluate if adjuvant chemotherapy could improve survival in these subjects. For this purpose, 16 patients underwent treatment with 5-Fluorouracil and cyclophosphamide (min. three, max six courses). The obtained results have shown a 5 year actuarial survival rate of about 48%. Our experience has not shown therefore any improvement compared with primary treatment alone.

Adult↗
PubMedDate not supplied

[Meningeal carcinosis: early clinical manifestations of inflammatory cancer of the breast].

Inflammatory carcinoma of the breast accounts for only 1-6% of mammary cancer in Caucasian women and is characterized by a poor prognosis; distant metastases frequently appear in fact in an early stage of disease and moreover metastatic spreading follows unpredictable ways. In this study we report on a case of a female patient in whom persistent signs of increased intracranial pressure, following the diagnosis of inflammatory carcinoma of the breast, have been referable to the tumour seeding the meninges in the absence of systemic disease. This peculiar and unusual form of neoplasia is up today a challenge for the clinician, both because of therapeutic difficulty and of unexpected metastases which, in turn, worsen the prognosis. Particularly, in our opinion, meningeal localization must be suspected even in the absence of distant metastases.

Adenocarcinoma↗