Biomedical subjects
Publications and source records attributed to G Boering.
Ten patients with unstable zygomatic fractures were treated with resorbable poly(L-lactide) (PLLA) plates and screws. The results show that this method of fixation gives good stability over a sufficiently long period to enable undisturbed fracture healing.
A randomized double-blind trial was performed to evaluate efficacy and tolerability of suprofen 200 mg (Suprocil) in comparison to paracetamol 500 mg after surgical extraction of a wisdom tooth. The study lasted 4 days per patient at the longest. Pain intensity and pain relief were evaluated by the patients using a visual analog scale. A total of 59 patients took part in the study; of these, 30 were on suprofen and 29 on paracetamol. The 30-min pain relief with paracetamol was superior to that obtained with suprofen. Roughly, the 90-min pain relief scores were somewhat higher for suprofen than for paracetamol. However, none of the differences were statistically significant. No significant difference was seen between the 2 treatment groups with respect to the frequency of the number of capsules taken per day. Broadly, the efficacy was good or excellent in 18 patients in each group. With suprofen, there were 8 moderate results and 4 insufficient ones. With paracetamol, 6 results were moderate and 5 insufficient or worse. No significant differences between the 2 treatments was seen. Tolerability was rated good by all but 1 patient in each treatment group; with suprofen, 1 result was moderate, while with paracetamol, 1 result was poor. Adverse reactions occurred in 3 patients on suprofen and in 2 patients on paracetamol, though these reactions could not be related to the use of the drug itself.
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To describe osteoarthritic changes of the temporomandibular joint (TMJ) and their relation to internal derangements, 22 randomly selected TMJ autopsy specimens were dissected and studied by light microscopy. Normal disc position was seen in eight joints, partial anterior displacement of the discs in eight joints, and complete anterior displacement of the discs in five joints; one joint had a perforated disc. Degenerative changes, such as horizontal splitting, clustering of chondrocytes, bone marrow fibrosis, sclerosis, erosion, cyst formation, and reduction in TMJ size, were found in 11 of the 14 joints with displacement or perforation of the disc and in four of the eight joints with normal disc position. Internal derangement appeared to be associated with osteoarthritis. The relations between remodeling, aging, internal derangement, and osteoarthritis are discussed.
A review of the literature concerning 37 cases of long-standing dislocation of the temporomandibular joint is presented. 3 new cases are added. A wide variety of methods of treatment has been used in the past. A survey of these methods will be given and a scheme of recommendation for managing the different clinical situations will be discussed.
To determine the spatial arrangement of collagen fibrils in articular cartilage of the human femoral head, three healthy femoral heads, obtained at necropsy, were examined by light microscopy and scanning electron microscopy. Light microscopic observations revealed no collagen fibril organization. Scanning electron microscopic observations showed a fine fibrillar texture throughout the articular cartilage. At the articular surface, smooth and fibrillated areas were detectable. Underneath the articular surface, the collagen network in the superficial zone showed a tighter appearance when compared with the homogeneous collagen network of the matrix in the deeper zones. The calcified cartilage zone was well demarcated from the uncalcified cartilage. The arcade model of Benninghoff [Z. Zellforsch. Mikrosk. Anat. 2: 783-862 (1925)] could not be confirmed. It was concluded that the organization of collagen fibrils in hyaline cartilage shows a three-dimensional network of randomly oriented fibrils.
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To obtain more insight into the pathogenesis of osteoarthrosis of the temporomandibular joint, we examined the ultrastructure of articular cartilage of six healthy and sixteen osteoarthrotic human mandibular condyles. Ultrastructural changes due to aging and osteoarthrosis are described and compared with the findings of other ultrastructural studies of articular cartilage of synovial joints. Aging was accompanied by some slight degenerative signs. Osteoarthrotic hyaline cartilage and fibrocartilage showed a striking similarity. The only ultrastructural difference was the presence of elastic fibers in the latter. Therefore, both seem to have the same pathogenesis. Several current statements on the pathogenesis of osteoarthrosis are discussed.
The aim of this study was to investigate the organization of collagen fibrils and the histopathologic alterations as well as the morphologic aspects of osteoarthritic articular cartilage of the human mandibular condyle. Nine osteoarthritic condyles, three obtained at necropsy and the other six during surgery, were examined by light microscopy and scanning electron microscopy. Light microscopic observations revealed features of progressive and regressive remodeling and the presence of clefts. Scanning electron microscopic observations showed the presence of thick, coiled fibrils at the joint surface and numerous osmiophilic lipid globules scattered between the collagen fibrils. The collagen fibrils were disordered. It was concluded that collagen fiber network disintegration and fatty degeneration comprise the osteoarthritic changes of the articular cartilage of the human mandibular condyle.
In the literature, posterior dislocation of the disc of the temporomandibular joint is seldom mentioned. Although this dislocation occurs rarely, it is important to differentiate this clinical entity from other joint disturbances. After a review of the literature, 3 patients are presented. Repositioning of the disc is succeeded in all 3 cases by manipulation. There were no signs of osteoarthrotic changes on follow-up.
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To determine the spatial arrangement of collagen fibrils in articular cartilage of the human mandibular condyle, ten healthy condyles obtained at necropsy were examined by light microscopy and scanning electron microscopy (SEM). Observations using light microscopy showed the existence of four different zones. The organization and alignment of the collagen fibrils were different in every zone and varied from layers to bundles of fibrils running parallel, obliquely, or radially to the articular surface. Observations using scanning electron microscopy revealed a thin, surface layer of disorganized small fibrils with a cotton-wool appearance and a well-organized architecture of collagen fibrils in every zone. It was concluded that the organization of collagen fibrils in articular cartilage shows a three-dimensional network with a special system in every zone.
The root canals of twelve pairs of human incisors without hard tissue or periodontal disease were treated with either formocresol or glutaraldehyde. The periapical reactions were compared histologically after periods varying between 6 and 8 weeks. A formocresol dressing always resulted in irritation of the periapical tissues, whereas little or no irritation was found after treatment with glutaraldehyde. It can be concluded that, after a vital pulpectomy, treatment of root canals with glutaraldehyde is faster than, as efficient as, and less irritating than treatment with formocresol.