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Biomedical subjects

G Bodem

Publications and source records attributed to G Bodem.

At least 73 records · Page 4Linked to original sources
PubMed1975

[Studies on metabolism and pharmacokinetics of alpha-acetyldigitoxin in man (author's transl)].

3H-alpha-Acetyl-digitoxin was administered to 5 patients i.v. and 3 patients p.o. The half-life of label in the plasma was 8.5 +/- 1 (i.v.) and 8.8 +/- 1 (p.o.) days. 20.9 +/- 3.6% (i.v.) and 21.3 +/- 2.9% (p.o.) of the radioactive dose were excreted into the urine in 6 days. Two patients excreted within 18 days 14.3 and 16.1% of the given dose with the stool. After oral administration 22.3% of the orally administered 3H-activity were eliminated into the feces by one patient. 63% (i.v.) and 53% (p.o.) of the chlorofrom-extracted 3H-activity in the urine could be attributed to digitoxin by means of thin-layer chromatography. The volatile content of plasma radioactivity was 4.07 +/- 0.1% (i.v.) and 6.78 +/- 0.2% (p.o.). The protein binding of a 4%. Albumin solution was 83 +/- 0.54%, for plasma 80.8 +/- 2%.

Acetyldigitoxins↗
PubMed1973

Pharmacodynamic studies of beta adrenergic antagonism induced in man by propranolol and practolol.

The pharmacodynamic activities of two beta adrenergic antagonists, propranolol and practolol, were compared in eight hypertensive patients. The activity of each antagonist was established in relation to its blood concentration at maximal and submaximal adrenergic blockade defined by inhibition of exercise tachycardia. Maximal inhibition of exercise tachycardia was comparable with both drugs and averaged 74+/-7% of the control value during drug treatment. This inhibition was achieved with a blood concentration of 2.5+/-0.4 mug/ml practolol and 0.10+/-0.08 mug/ml propranolol. The antagonist activities of these drugs against adrenergic stimulation with isoproterenol infusion indicated a much greater relative potency of propranolol against this stimulus, and in vivo estimates of PA(2) values differed by more than 600-fold. Relative antagonist activity of practolol during isoproterenol stimulation was equivalent both at cardiac (inotropic and chronotropic) and at vascular adrenergic receptors, whereas greater antagonist activity of propranolol was observed at vascular receptors than at cardiac receptors. Thus, the activity of practolol was not limited to cardiac receptors as previously suggested. Practolol did not reduce cardiac output at any dose level and the effect on resting blood pressure was small. Both practolol and propranolol had much greater hypotensive activity during exercise. These studies have defined the differing pharmacodynamic activities on the cardiovascular system of two effective beta adrenergic receptor antagonists and have established the blood levels of these antagonists necessary to achieve effective adrenergic blockade.

Acetanilides↗