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Biomedical subjects

G Bodem

Publications and source records attributed to G Bodem.

At least 19 recordsLinked to original sources
PubMed1980

Comparative pharmacodynamics and plasma levels of beta-adrenoceptor blocking drugs.

1. Metoprolol (ME), pindolol (PI) and propranolol (PR) were studied in nine subjects at different doses and at 'maximum beta-adrenoceptor blockade' at a defined exercise load. Exercise tests were performed after each dosing period; isoprenaline stimulation was studied at the highest dose level. 2. ME and PR reduced heart rate at rest with most doses tested, while PI had no effect on resting heart rate. 3. Exercise heart rate was reduced with the smallest daily doses (ME 75 mg; PI 7.5 mg; PR 60 mg), and maximum reduction was from 163 to 116 beats/min (ME), 124 (PT) and 115 (PR) beats/min with daily doses of 242, 23 and 233 mg, respectively. 4. Resting blood pressure was not significantly affected by any beta-adrenoceptor blocker dose, but exercise induced blood pressure decreased from 166 to 130 (ME), 138 (PI) and 131 (PR) mm Hg, respectively. 5. Mean plasma concentrations at 'maximum beta-adrenoceptor blockade' were 158 (ME), 24 (PI) and 159 (PR) ng/ml without significant differences in the plasma level variation between beta-adrenoceptor blockers. 6. Isoprenaline doses required to increase heart rate by 30 beats/min were 3.8 microgram (control), 22 microgram (ME), 458 microgram (PI) and 200 microgram (PR), respectively. The differences may be due to different ratios of beta 1, beta 2 activity of the beta-adrenoceptor blockers tested.

Adrenergic beta-Antagonists↗
PubMed1979

[Biological availability of digoxin from a combination drug].

In a randomized cross-over study with 14 voluntary test persons the absolute biological availability of digoxin in Card-Dusodril 1/8 and 1/4 respectively was investigated. 6 test persons received 4 drag. Card-Dusodril 1/8 (= 0.5 mg digoxin), 8 test persons 4 drag. Card-Dusodril 1/4 (= 1 mg digoxin) orally, in comparison to the corresponding group with intravenously applied digoxin as standard. Based on the cumulative digoxin excretion in the urine an absolute biological availability of Card-Dusodril 1/8 of 79%, of Card-Dusodril 1/4 of 76% could be demonstrated. With regard to an average resorption of oral digoxin preparations of approx. 70%, the present values, which correspond in direct comparison to those of acetyl digoxin, can be considered good. Maximum serum levels were achieved after 86 +/- 6.8 minutes which also indicates a quick resorption.

Administration, Oral↗
PubMed1979

[Differential diagnosis with adrenergic beta blockers].

Several beta-adrenergic blocking agents are on the market in Western Germany. They differ not only in their beta-blocking potency and selectivity but also in their unspecific effects, as intrinsic activity and membrane stabilizing properties. Also the pharmacokinetic behaviour varies widely. From the clinical point of view the selectivity is important for avoiding an aggravation of an underlying obstructive lung disease of effects in the peripheral vascular bed. The intrinsic activity on the one hand might be responsible for some side effects like nightmare or headache; the slowing of resting heart rate on the other hand might be less pronounced. The discrepancies of bio-availability might be overcome by increasing the oral dose.

Adrenergic beta-Antagonists↗
PubMed1979

[Digoxin induced changes in the exercise ECG and its relation to plasma concentrations (author's transl)].

The effects of a single intravenous dose (1.5 mg) of diogoxin on the resting and exercise ECG were studied over several days in twelve normal subjects. Maximal ST-segment and T-wave changes were observed 24 h after drug administration. A significant ST-segment depression and decrease in T-wave amplicude were still observed on the 7th and 11th day after the glycoside dose, in spite of undetectable digoxin plasma concentrations. There was no correlation between digoxin plasma concentration and ECG-changes. In order to avoid false positive ischaemic ST-segment responses to exercise, a therapy with digoxin should be discontinued for at least 2 weeks before the exercise test.

Adult↗
PubMed1979

Enhanced transformation of digitoxin to dihydrodigitoxin in humans with renal failure.

A gas-chromatographic mass-spectroscopic technique was used to identify dihydrodigitoxin, a metabolite of digitoxin, in the plasma of healthy volunteers and patients with renal failure. Digitoxin and dihydrodigitoxin were extracted from plasma and derivatized with heptafluorbutyric anhydride. In normal subjects, only minimal concentrations of dihydrodigitoxin in plasma could be determined (1 ng/ml) after an intravenous bolus injection of digitoxin. Under a chronic treatment with a daily dose of 0.1 mg digitoxin in three out of seven individuals, detectable dihydrodigitoxin plasma levels were observed (0.7, 1.5, and 1.7 ng/ml) (Table I). On the other hand, in seven patients with renal failure, high dihydrodigitoxin plasma concentrations (8.9 +/- 0.9 ng/ml) were shown which were in a similar range as those of the parent compound (8.7 +/- 2.2 ng/ml) under a maintenance treatment with digitoxin.

Adult↗
PubMed1978

[Vascular effects of digitalis in human extremities (author's transl)].

The effect of lanatosid C on the peripheral vascular system was studied in a randomized double-blind cross-over study. 1 mg lanatosid C in saline or a corresponding volume of saline were applied intravenously for 30 min to healthy subjects. A significant drop of 28% in blood flow and an increase of peripheral vascular resistence at rest of 44% during and after the application of the cardiac glycoside could be seen while the placebo effect was minimal.

Adult↗
PubMed1978

Single and multiple dose pharmacokinetics of pindolol.

The pharmacokinetics of pindolol were studied in six healthy individuals following a single 10 mg dose (SD) and multiple (5 mg tid over 6 days) dose (MD). The plasma elimination half-life was identical after SD (4.7 +/- 0,8h) and MD (4.1 +/- 1.1h). Steady state plasma concentrations were reached after 36 h and remained stable thereafter. The variation in steady state concentrations was small in each individual and also between individuals. The steady state concentration of pindolol can be predicted from the pharmacokinetic data obtained after a single dose. The results of the present study suggest that the disposition of pindolol is linear over the concentration range studied.

Adult↗
PubMed1978

Spironolactone.

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Androgen Antagonists↗