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Biomedical subjects

G Bloch

Publications and source records attributed to G Bloch.

136 records · Page 8Linked to original sources
PubMedDate not supplied

Computed tomography of thoracic aortic dissection: accuracy and pitfalls.

During a 5 year period, 137 patients with suspected acute aortic dissection were screened by CT. The radiologic diagnosis of dissection was made in 54 cases and eliminated in 76. There were seven false-negative CT examinations. Surgical and angiographic correlations or clinical follow-up were obtained with all patients.

Acute Disease↗
PubMedDate not supplied

[Cor triatriatum. Anatomical forms and surgical treatment of 6 consecutive cases].

Six cases of cor triatriatum documented and operated on at Henri-Mondor hospital between 1980 and 1984 are reported. Ages at the time of surgery ranged from 8 months to 57 years. Four of the 6 patients presented with pulmonary hypertension. Anatomic types consisted of 4 diaphragmatic types and 2 more complex malformations. Associated lesions were present in all but one patients. They consisted mostly of interatrial defects (depending on their position with regard to the intra-atrial membrane, they play a determinant role in the symptomatology) and of a left superior vena cava (which might play a role in the embryogenesis of the malformation). Except for one early postoperative death, results of surgery were excellent for all patients, with a mean follow-up of 5 years. This series, compared with the literature, allows precising the embryologic and anatomic aspects of the malformation and the surgical techniques in complex types.

Child↗
PubMedDate not supplied

Efficacy of lactobionate-enriched cardioplegic solution in preserving compliance of cold-stored heart transplants.

Cardioplegic solutions of the extracellular type are commonly used as storage media for heart transplants. Because this type of formulation was not originally designed for preventing hypothermically induced edema, we assessed the effects of supplementing a standard, extracellular-like cardioplegic solution with the high molecular weight impermeant lactobionate on water content and postischemic compliance of isolated rat hearts. In one series of experiments, hearts were immersed in either a standard cardioplegic solution of the extracellular type or in the same solution supplemented with lactobionate (80 mmol/L). Hearts were then processed for measurements of water content after 4 hours, 6 hours, and 8 hours of storage at 4 degrees C. In a second series of experiments, hearts were stored in the same solutions for 4 hours and 8 hours and subsequently reperfused for 1 hour on a Langendorff column, at which time left ventricular pressure-volume curves were constructed and compared with those obtained during the preischemic perfusion. Lactobionate-treated hearts gained significantly less water than controls after 4 hours and 6 hours of storage, but the difference was no longer significant at the 8-hour time point. In contrast, the treated group yielded a significantly better recovery of compliance after both 4 hours and 8 hours of storage, suggesting that lactobionate might exert protective effects in addition to those caused by its impermeant properties, possibly involving calcium chelation and subsequent limitation of calcium-dependent contracture. Extracellular-type cardioplegic solutions are attractive because a single solution can be used during all phases of the transplantation procedure.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

C13 NMR spectroscopy of lipids: a simple method for absolute quantitation.

There is both epidemiological and experimental evidence of the effect of fatty acid molecular structure, particularly the degree of saturation in fatty acyl chains, on the growth and regulation of certain tumours. In vivo carbon nuclear magnetic resonance spectroscopy has previously been shown to offer a non invasive technique for the evaluation of proportions of monounsaturated, polyunsaturated and saturated fatty acids in human adipose tissue. We present a simple method, which uses both endogenous water and fat as reference, to quantify in molar terms these lipid sub-categories for tissues other than pure fat. This could provide additional information in the debate on the protective effect in cancer of high polyunsaturated fatty acid (PUFA) diet. The method was validated by characterization of a lipid emulsion of known composition in various experimental set-ups and was applied to measure the lipid composition of the calves of two volunteers. Limitations and perspectives of the method are discussed.

Body Water↗