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Biomedical subjects

G Blasi

Publications and source records attributed to G Blasi.

At least 19 recordsLinked to original sources
PubMed1999

Monitoring of antimicrobial prophylaxis in general surgery.

The incidence of infections in general surgery is related to different factors. Cost-benefit analysis of antimicrobic prophylaxis is positive, even though incorrect use may be even dangerous (development of resistance and/or superinfections, for instance). The authors report data on a study concerning a total of 316 patients divided into two series, who had antimicrobic prophylaxis before a surgical operation. 274 patients out of 316 (or 86.7%) had an ultra-short (one-shot-only) or short (<24 hours) prophylaxis, 42 (13.3%) standard (>24 hours). The operations performed were classified following class of contamination, i.e. I (clean), II (potentially contaminated), III (contaminated). Antibiotics used were ceftizoxime, cefepime, ceftriaxone, piperacillin and gentamicin in combination. A total of 16 postoperative infections was observed (5%); 11 of these 16 belonged to class III operations. Escherichia coli and Staphylococcus aureus were isolated in most of the infected wounds. The data confirm what is reported in the literature. The authors conclude that a preoperative single-shot 3rd or 4th generation cephalosporin reduces the incidence of wound infections in clean and clean-contaminated surgery.

Antibiotic Prophylaxis↗
PubMed1997

Effect of granulocyte-macrophage colony-stimulating factor on prevention of mucositis in head and neck cancer patients treated with chemo-radiotherapy.

Twenty-nine previously untreated patients with squamous cell carcinoma of the oral cavity and pharynx underwent a treatment program with four courses of chemotherapy alternated with three courses of radiotherapy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was administered at a dose of 5 micrograms/mg subcutaneously on the same day as radiation treatment in order to prevent mucositis. No grade 4 mucositis was reported; only four episodes of grade 2 mucositis and thirteen grade 2. Comparing these results with historical patients treated with the same chemotherapy-radiation program but without GM-CSF, the authors concluded that GM-CSF is an effective treatment for preventing mucositis produced by chemotherapeutic and/or radiotherapeutic interventions in patients at high risk of oropharyngeal mucosal damage.

Aged↗
PubMed1996

[The correlation between an increase in subgingival temperature and the concentration of volatile fatty acids of bacterial origin present in periodontal pockets].

The results obtained in this study indicate that the mean subgingival temperature measured in periodontal patients is significantly higher compared to that obtained from healthy subjects. The increase in subgingival temperature observed in periodontal patients, is proportional to the concentration of short-chain fatty acids (SCFA) present in the gingival fluid. The highest temperature values were observed when suppuration and high levels of SCFA were both present in the same site. Theoretical considerations are presented which suggest a possible role of metabolically activated neutrophils in the local temperature increase. In any case, considering that the local increase in temperature is associated with an inflammatory process and that SCFA are bacterial "toxins" capable of inhibiting the immunological host response, the results presented in this study agree with the hypothesis that SCFA may be involved in the pathogenesis of chronic adult periodontitis.

Adult↗
PubMed1990

Prevalence of Streptococcus mutans and dental decay in schoolchildren living in Genoa (Italy).

In this study population (105 schoolchildren aged 5.5-11.5 yrs), dental decay was detected in 75.2% and S. mutans in 55.2% of the subjects. The presence of S. mutans was assessed - using the selective GSTB medium - in unstimulated saliva and in pooled occlusal and pooled buccal plaques from the four most posterior teeth. All three samples showed association between S. mutans presence and caries prevalence. Of the two types of plaque, the occlusal not only had a higher frequency of isolation but also a significantly higher proportion of S. mutans. The presence of S. mutans was significantly associated with both caries prevalence and extent of caries experience. Both S. mutans prevalence and S. mutans proportion in plaque increased with the number of decayed teeth present among those sampled. Sucrose consumption between meals appeared to be more correlated with the degree of caries experience rather than with caries or S. mutans prevalence. A second clinical examination was scheduled six months after the first for S. mutans-positive children who either were free of active carious lesions, or were caries-active but without signs of dental decay in the sampled teeth. Caries-active subjects proved to be more prone to new carious lesions than caries-free subjects, who tended to remain caries-free even when they had a high proportion of S. mutans in plaque, thus indicating the basic importance of the host factor in the caries process.

Child↗
PubMed1989

[Bilaminar technic in the treatment of gingival recessions].

Bilaminar procedures represent an evolution in the treatment of marginal tissue recessions. A connective tissue graft removed from the palate and over which a pedicle flap is sutured, is used in these procedures. The advantages of these new procedures are: 1) sure predictability of graft survival to which a double-blood supply is guaranteed; 2) primary intention healing at the donor site, with minimum post-operative discomfort; 3) excellent esthetic results consisting of better color blending between graft and adjacent tissues and absence of keloid- like scars, very common after free gingival grafts.

Connective Tissue↗
PubMedDate not supplied

[Magnetic attachments for implants in complete dentures].

In this research work we examine and apply to patients new types of technologies, describing advantages and disadvantages of using them. This osseointegrated implantation with magnetic prosthetic connection, allow to stabilize complete denture in patients suffering from serious atrophy.

Dental Implantation, Endosseous↗
PubMedDate not supplied

[Antiplaque agents].

Explore the source record for details and available documents.

Combined Modality Therapy↗