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Biomedical subjects

G Blache

Publications and source records attributed to G Blache.

7 recordsLinked to original sources

[Prognostic value of a single umbilical artery. 87 cases].

OBJECTIVE: To study the effect of a single umbilical artery on infant prognosis. METHOD: Unicentric retrospective case-control study based on 18,425 births and semi-late pregnancy interruptions. RESULTS: There were 87 cases of single umbilical artery, frequently associated with a familial history of malformation in the sibhood (6.8%), gravid pathology (hypertension 11.5%, diabetes 6.8%), funicular anomaly (32%). One or several malformations were seen in 21% of the infants, the main cause of infant mortality (9%) and morbidity. The case-control study demonstrated that single umbilical artery corresponded to a moderate reduction in weight (-310 g), term (-1.4 weeks gestation), AGPAR scor at 1 and 5 minutes (-0.7) which was not significant when single umbilical artery was the sole pathology. CONCLUSION: When occurring alone, single umbilical artery has little effect on infant prognosis which is more dependant on associated malformations and gravid pathologies determining antenatal and postnatal management.

Apgar Score

[Hydatidiform mole in Vietnam. The contribution of ultrasonography].

One-hundred-and-four cases of histopathologically confirmed hydatiform moles were subjected to ultrasound examination at the Hung Vuong Hospital, Ho-Chi-Minh-ville (Vietnam) over a period of 16 months (1988-1989). The diagnosis was confirmed only in some cases on clinical grounds (18%) or by laboratory tests (52%). In contrast, typical ultrasound signs were found in 82% of cases; in the other 18% of cases, other aspects had suggested disorders calling for aspiration (partial mole, clear ovum, pregnancy terminated). Some ultrasound images, highly suggestive of mole, were found in occasional cases of mucoid ovarian cyst, endometrial cancer or cystic necrobiosis of fibroma (HCG tests negative). Despite its limitations in Vietnam ultrasound constitutes the primary method of detecting hydatiform mole, the acquisition of practical experience is facilitated by the high number of cases and the concentration of cases reported.

Abortion, Threatened

[Comparison of classic and digital pelvimetry for measuring the medial transverse diameter in 50 female patients].

The medial transverse diameter (MTD) has been measured in 50 female patients using both CT and classical pelvimetry. Comparison between these two matched series allows to confirm (p less than 0.001) that the measurement obtained by CT is on the average smaller than that obtained by classical pelvimetry. The relative mean deviation is 3%, the means differ by 4 mm. Management of obstetrical patients taking into account measurements obtained by pelvimetry (Magnin indices) should then be modified depending on the results obtained by this new technique of scanopelvimetry, that will soon become the technique of reference.

Female

[Choriocentesis: comparison of the effectiveness of a new choriocentesis needle and a transcervical biopsy forceps].

71 samples taken by the transabdominal route were compared with 71 samples taken by forceps through the cervix. A fine (1 mm) transabdominal choriocentesis needle with a thin wall (0.1 mm), a short bevel, and a lateral hole was made to bring together simplicity, effectiveness and safety; success was obtained in 95% of the cases (39/41) of our last 41 samples on the first attempt. For comparison with the forceps, the success rate on the first attempt was only 66% (26/41), but it rose to 97.5% if the patient could take 3 attempts at most. The forceps made it possible to collect a mean quantity large enough (19.9 mg) but it was quite variable (16.7 mg being the range) of complete villi, whereas the choriocentesis needle only gathered a smaller volume (12.7 mg) but more reliable (the range being 3.7 mg). The villi were fragmented, however. To work out the study of the DNA and the karyotype, there is a choice between the forceps and the needle. This choice depends principally on the damage the two techniques can do. This has not been worked out yet in our study except indirectly.

Biopsy