The production of a haematoma in the hindleg of rabbits represents a simplification of post-traumatic models. The lungs, one of the target organs, show similar micromorphological alterations to those described in traumatised human beings. The lungs of rabbits, bearing a hindleg haematoma for 24 hr, showed a significantly increased incidence of micromorphological lung alterations compared to the control group. Moreover, measurement revealed a significantly decreased lung compliance within the haematoma groups. It was demonstrated that whether the haematoma was subcutaneous or intramuscular, similar alterations were seen in lung histology, and in lung compliance values. Studies on the activity of superoxide dismutase in lung tissue homogenates demonstrated a significant decrease in those rabbits having had a haematoma intramuscularly for 24 hr.

Acute Disease↗

PubMed1979

[Biokinetic investigation of thallium-201 and technetium-99m-tin-pyrophosphate in experimental myocardial infarction in the cat].

Explore the source record for details and available documents.

Animals↗

PubMed1979

Experimental studies on the use of microwaves for the localized heat treatment of the prostate.

High frequency tumor therapy requests heating of a well defined area, whereas the surroundings should be unaffected. This sort of therapy should be more tolerable than a whole body heating. For this purpose a new developed microwave applicator (433.9 MHz) for local heat application was tested in animals. Using this rectally insertable applicator the prostate of dogs were irradiated. The temperature of the rectum, the urethra and the prostate were measured and recorded using specially developed thermistor probes. The effect of hyperthermia on the prostate and the surrounding tissue was analyzed macroscopically and micromorphologically. It was shown that local heating of the prostate of dogs is possible. The induced damages of the prostate and surrounding tissue is not severe enough to be untolerable.

Animals↗

PubMed1979

[Anesthsiological experiences in experimental surgery].

The paper reports experience with methods of anaesthesia in rabbits, rats, mice, guinea-pigs, pigs, sheep, baboons, dogs and cats. Special problems of handling, mode of injection and intubation are discussed. A comprehensive survey of literature provides further information about the proposed patterns of anaesthesia and informs about other anaesthetic methods, not practised by the authors.

Alcuronium↗

PubMed1979

[Animal experimental studies on partial kidney function after temporary tourniquet ischemia with and without blood substitute therapy].

70 rats were subjected to tourniquet ischemia of a hind limb for a period of two and three hours. 12 rats served as controls. After release of the 3 hours tourniquets 20 rats were treated either with Ringer's solution or with hydroxyethyl starch. Kidney function and morphology, systolic blood pressure, hematocrit, serum electrolytes, creatinine and urea were studied as different times of recirculation. 1. Reduction in renal function was only observed after releasing the tourniquets. 2. The extent of reduction in renal function depended on the time of ischemia and time of recirculation. 3 hours of tourniquet with two hours of recirculation led to the largest extent of reduction in renal function and renal parenchymal lesions. 3. If the infusion of HES was applied at the beginning of recirculation, reduction in renal function was prevented, as well as parenchymal lesions. Ringer's infusion, however, did not improve kidney function to a normal range.

Animals↗

PubMed1979

[Diaplacental transfer of verapamil in guinea pigs (author's transl)].

Verapamil (1--50 mcg/kg/min) was given to guinea pigs by intravenous infusion for 30 minutes. The average clinical dosage amounts to 1 (0,5--2) mcg/kg/min. At doses of 1--10 mcg/kg/min we could not find pharmacologically effective concentrations of verapamil in plasma, although concentrations in mother rose corresponding to administered doses. Only at dosage 50 mcg/kg/min we found comparatively to the mother low, but clearly measurable concentrations also in fetal plasma. That means: Verapamil, administered to guinea pigs--hemomonochorial placentation like man--in dosage, given for tocolysis does not appear in fetal plasma with pharmacologically effective concentration.

Animals↗

PubMed1979

[Free jejunum graft as substitute of the cervical esophagus done with microsurgical technic--morphological and functional results in long-term studies].

It is possible to undertake a free transplantation of the jejunum with a low rate of thrombosis by a microsurgical technique of vascular anastomosis. The animals could be nourished sufficiently via the interponate with pasty food. Peristalsis within the interponate was retained. Stenoses caused by a periluminar cicatrix are possible. After 1 year a transformation of connective tissue of the interponate was not observed.

Angiography↗